B Andreas Berk
Medium-chain triglycerides dietary supplement improves cognitive abilities in canine epilepsy
Andreas Berk, B; Packer, R M A; Hong Law, T; Wessmann, A; Bathen-Nöthen, A; Jokinen, T S; Knebel, A; Tipold, A; Pelligand, L; Volk, H A
R M A Packer
T Hong Law
T S Jokinen
H A Volk
Objective: Cognitive impairments (CI) have recently been identified in canine epilepsy patients. A medium-chain triglyceride (MCT) enriched diet has been demonstrated to improve cognition in aged dogs and seizure control in canine epilepsy. This study evaluates the short-term effects of MCT oil consumption on cognitive abilities in dogs with epilepsy, a naturally occurring animal model.
Methods: A 6-month multi-center, prospective, randomized, double-blinded, controlled cross-over diet trial was conducted comparing dietary supplementation (DS) of MCT-oil to a control oil. Allocation to dietary oil supplements, consisting of 9% total caloric intake, was block-randomized and supplemented into each dogs’ diet for three months followed by a respective switch of DS oil for a further three months. Non-invasive cognitive tests and a validated psychometric tool were utilized to evaluate cognitive function and perturbations associated with dietary intervention.
Results: Twenty-nine dogs completed the trial, of which 18 completed non-invasive cognitive testing. Spatial-working memory (p=0.008), problem-solving ability (p=0.048) and owner-reported trainability (p=0.041) were significantly improved during MCT-oil supplementation compared to control-DS.
Significance: MCT-oil DS improves cognition in dogs with epilepsy when compared to a control-DS. MCT supplementation may represent a promising option to address CI associated with epilepsy.
Andreas Berk, B., Packer, R. M. A., Hong Law, T., Wessmann, A., Bathen-Nöthen, A., Jokinen, T. S., …Volk, H. A. (in press). Medium-chain triglycerides dietary supplement improves cognitive abilities in canine epilepsy. Epilepsy & Behavior, https://doi.org/10.1016/j.yebeh.2020.107608
|Journal Article Type||Article|
|Acceptance Date||Oct 29, 2020|
|Online Publication Date||Nov 30, 2020|
|Deposit Date||Nov 5, 2020|
|Publicly Available Date||Dec 1, 2021|
|Journal||Epilepsy & Behavior|
|Peer Reviewed||Peer Reviewed|