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Quantification of clinically applicable stimulation parameters for precision near-organ neuromodulation of human splenic nerves (2020)
Journal Article
Gupta, I., Cassará, A. M., Tarotin, I., Donega, M., Miranda, J. A., Sokal, D. M., Ouchouche, S., Dopson, W., Matteucci, P., Neufeld, E., Schiefer, M. A., Rowles, A., McGill, P., Perkins, J., Dolezalova, N., Saeb-Parsy, K., Kuster, N., Yazicioglu, R. F., Witherington, J., & Chew, D. J. (2020). Quantification of clinically applicable stimulation parameters for precision near-organ neuromodulation of human splenic nerves. Communications Biology, 3(1), 577

Abstract: Neuromodulation is a new therapeutic pathway to treat inflammatory conditions by modulating the electrical signalling pattern of the autonomic connections to the spleen. However, targeting this sub-division of the nervous system presents sp... Read More about Quantification of clinically applicable stimulation parameters for precision near-organ neuromodulation of human splenic nerves.

Current trends in fluid and blood product availability in small animal practices in the UK (2020)
Journal Article
Beeston, D., Charnock, J., & Cook, S. (2020). Current trends in fluid and blood product availability in small animal practices in the UK. Journal of Small Animal Practice, https://doi.org/10.1111/jsap.13242

Objectives

To investigate and discuss current fluid and blood products stocked in small animal practices in the UK.

Methods

An online survey was circulated to small animal veterinary practices across the UK. The survey included questions reg... Read More about Current trends in fluid and blood product availability in small animal practices in the UK.

Current fluid and blood product availability in small animal practices in the UK URN SR2019 ‐0008 (2020)
Journal Article
Beeston, D., Charnock, J., & Cook, S. (2020). Current fluid and blood product availability in small animal practices in the UK URN SR2019 ‐0008. Journal of Small Animal Practice, https://doi.org/10.1111/jsap.13242

Objectives

To investigate and discuss current fluid and blood products stocked in small animal practices in the UK.

Methods

An online survey was circulated to small animal veterinary practices across the UK. The survey included questions reg... Read More about Current fluid and blood product availability in small animal practices in the UK URN SR2019 ‐0008.

Extracellular Nucleotides Regulate Arterial Calcification by Activating Both Independent and Dependent Purinergic Receptor Signaling Pathways (2020)
Journal Article
Opdebeeck, B., Orriss, I., Neven, E., D’Haese, P. C., & Verhulst, A. (2020). Extracellular Nucleotides Regulate Arterial Calcification by Activating Both Independent and Dependent Purinergic Receptor Signaling Pathways. International Journal of Molecular Sciences, 21(20), e7636

Arterial calcification, the deposition of calcium-phosphate crystals in the extracellular matrix, resembles physiological bone mineralization. It is well-known that extracellular nucleotides regulate bone homeostasis raising an emerging interest in t... Read More about Extracellular Nucleotides Regulate Arterial Calcification by Activating Both Independent and Dependent Purinergic Receptor Signaling Pathways.

Emerging and Adjunctive Therapies for Spinal Cord Injury Following Acute Canine Intervertebral Disc Herniation (2020)
Journal Article
Lewis, M. J., Granger, N., Jeffery, N. D., & The Canine Spinal Cord Injury Consortium (CANSORT-SCI). (2020). Emerging and Adjunctive Therapies for Spinal Cord Injury Following Acute Canine Intervertebral Disc Herniation. Frontiers in Veterinary Science, 7, 579933

Some dogs do not make a full recovery following medical or surgical management of acute canine intervertebral disc herniation (IVDH), highlighting the limits of currently available treatment options. The multitude of difficulties in treating severe s... Read More about Emerging and Adjunctive Therapies for Spinal Cord Injury Following Acute Canine Intervertebral Disc Herniation.

Unravelling the health status of brachycephalic dogs in the UK using multivariable analysis (2020)
Journal Article
O’Neill, D. G., Pegram, C., Crocker, P., Brodbelt, D. C., Church, D. B., & Packer, R. M. A. (2020). Unravelling the health status of brachycephalic dogs in the UK using multivariable analysis. Scientific Reports, 10(1),

Brachycephalic dog breeds are regularly asserted as being less healthy than non-brachycephalic breeds. Using primary-care veterinary clinical data, this study aimed to identify predispositions and protections in brachycephalic dogs and explore differ... Read More about Unravelling the health status of brachycephalic dogs in the UK using multivariable analysis.

A description of blend electrolysis for treatment of canine distichiasis: 78 cases (2012-2017). (2020)
Journal Article
Ioannides, J., Everson, R., Matas Riera, M., & Dawson, C. (2020). A description of blend electrolysis for treatment of canine distichiasis: 78 cases (2012-2017). Veterinary Record,

To describe a population of dogs treated with blend electrolysis for distichiasis at The Royal Veterinary College and report the complications seen. In part 1, records were reviewed from 2012 to 2017 and a population of 78 dogs with distichiasis trea... Read More about A description of blend electrolysis for treatment of canine distichiasis: 78 cases (2012-2017)..

Phenotypic Spectrum of α-Dystroglycanopathies Associated With the c.919T>a Variant in the FKRP Gene in Humans and Mice (2020)
Journal Article
Brown, S. C., Fernandez-Fuente, M., Muntoni, F., & Vissing, J. (2020). Phenotypic Spectrum of α-Dystroglycanopathies Associated With the c.919T>a Variant in the FKRP Gene in Humans and Mice. Journal of Neuropathology and Experimental Neurology,

Abstract Mutations in the fukutin-related protein gene, FKRP, are the most frequent single cause of α-dystroglycanopathy. Rare FKRP mutations are clinically not well characterized. Here, we review the phenotype associated with the rare c.919T>A mu... Read More about Phenotypic Spectrum of α-Dystroglycanopathies Associated With the c.919T>a Variant in the FKRP Gene in Humans and Mice.

Animal Research beyond the Laboratory: Report from a Workshop on Places Other than Licensed Establishments (POLEs) in the UK (2020)
Journal Article
Palmer, A., Greenhough, B., Hobson-West, P., Message, R., Aegerter, J. N., Belshaw, Z., Dennison, N., Dickey, R., Lane, J., Lorimer, J., Millar, K., Newman, C., Pullen, K., Reynolds, S. J., Wells, D. J., Witt, M. J., & Wolfensohn, S. (2020). Animal Research beyond the Laboratory: Report from a Workshop on Places Other than Licensed Establishments (POLEs) in the UK. Animals, 10(10), e1868

Research involving animals that occurs outside the laboratory raises an array of unique challenges. With regard to UK legislation, however, it receives only limited attention in terms of official guidelines, support, and statistics, which are unsurpr... Read More about Animal Research beyond the Laboratory: Report from a Workshop on Places Other than Licensed Establishments (POLEs) in the UK.

Transverse sectioning in the evaluation of skin biopsy specimens from alopecic dogs. (2020)
Journal Article
Bond, R., Hendricks, A., Patterson-Kane, J., Stevens, K., & Brooks Brownlie, H. W. (2020). Transverse sectioning in the evaluation of skin biopsy specimens from alopecic dogs. Journal of Small Animal Practice,

Transverse sectioning of skin biopsy specimens has revolutionised assessment of human alopecia by demonstration of every hair in each specimen, allowing quantitative evaluation of follicular activity. Since only vertical sectioning is performed routi... Read More about Transverse sectioning in the evaluation of skin biopsy specimens from alopecic dogs..

Corneo‐limbo‐conjunctival transposition to treat deep and perforating corneal ulcers in dogs: A review of 418 eyes and corneal clarity scoring in 111 eyes (2020)
Journal Article
Cebrian, P., Escanilla, N., Lowe, R. C., Dawson, C., & Sanchez, R. F. (2020). Corneo‐limbo‐conjunctival transposition to treat deep and perforating corneal ulcers in dogs: A review of 418 eyes and corneal clarity scoring in 111 eyes. Veterinary Ophthalmology,

Purpose

To report surgical and corneal clarity scores (CCSs) of corneo‐limbo‐conjunctival transpositions (CLCTs) in a large number of canine cases.

Methods

Retrospective review of records that underwent CLCT to repair deep ulcers or perforat... Read More about Corneo‐limbo‐conjunctival transposition to treat deep and perforating corneal ulcers in dogs: A review of 418 eyes and corneal clarity scoring in 111 eyes.

Walking in mud: Remarkable Pleistocene human trackways from White Sands National Park (New Mexico) (2020)
Journal Article
Bennett, M. R., Bustos, D., Odess, D., Urban, T. M., Lallensack, J. N., Budka, M., Santucci, V. L., Martinez, P., Wiseman, A. L. A., & Reynolds, S. C. (2020). Walking in mud: Remarkable Pleistocene human trackways from White Sands National Park (New Mexico). Quaternary Science Reviews, 249, 106610

Human tracks at White Sands National Park record more than one and a half kilometres of an out- and-return journey and form the longest Late Pleistocene-age double human trackway in the world. An adolescent or small adult female made two trips separa... Read More about Walking in mud: Remarkable Pleistocene human trackways from White Sands National Park (New Mexico).

Integrating Genetic and Genomic Analyses of Combined Health Data Across Ecotypes to Improve Disease Resistance in Indigenous African Chickens (2020)
Journal Article
Banos, G., Lindsay, V., Desta, T. T., Bettridge, J., Sanchez-Molano, E., Vallejo-Trujillo, A., Matika, O., Dessie, T., Wigley, P., Christley, R. M., Kaiser, P., Hanotte, O., & Psifidi, A. (2020). Integrating Genetic and Genomic Analyses of Combined Health Data Across Ecotypes to Improve Disease Resistance in Indigenous African Chickens. Frontiers in Genetics, 11, 543890

Poultry play an important role in the agriculture of many African countries. The majority of chickens in sub-Saharan Africa are indigenous, raised in villages under semi-scavenging conditions. Vaccinations and biosecurity measures rarely apply, and i... Read More about Integrating Genetic and Genomic Analyses of Combined Health Data Across Ecotypes to Improve Disease Resistance in Indigenous African Chickens.

The Growth of Eimeria tenella: Characterization and Application of Quantitative Methods to Assess Sporozoite Invasion and Endogenous Development in Cell Culture (2020)
Journal Article
Marugan-Hernandez, V., Jeremiah, G., Aguiar-Martins, K., Burrell, A., Vaughan, S., Xia, D., Randle, N., & Tomley, F. (2020). The Growth of Eimeria tenella: Characterization and Application of Quantitative Methods to Assess Sporozoite Invasion and Endogenous Development in Cell Culture. Frontiers in Cellular and Infection Microbiology, 10, 579833

In vitro development of the complete life cycle of Eimeria species has been achieved in primary cultures of avian epithelial cells with low efficiency. The use of immortalized cell lines simplifies procedures but only allows partial development throu... Read More about The Growth of Eimeria tenella: Characterization and Application of Quantitative Methods to Assess Sporozoite Invasion and Endogenous Development in Cell Culture.

Why are the fastest runners of intermediate size? Contrasting scaling of mechanical demands and muscle supply of work and power (2020)
Journal Article
Usherwood, J. R., & Gladman, N. W. (2020). Why are the fastest runners of intermediate size? Contrasting scaling of mechanical demands and muscle supply of work and power. Biology Letters, 16(10), 20200579

The fastest land animals are of intermediate size. Cheetah, antelope, greyhounds and racehorses have been measured running much faster than reported for elephants or elephant shrews. Can this be attributed to scaling of physical demands and explicit... Read More about Why are the fastest runners of intermediate size? Contrasting scaling of mechanical demands and muscle supply of work and power.

Lockdown measures in response to COVID-19 in nine sub-Saharan African countries (2020)
Journal Article
Haider, N., Osman, A. Y., Gadzekpo, A., Akipede, G. O., Asogun, D., Ansumana, R., Lessells, R. J., Khan, P., Hamid, M. M. A., Yeboah-Manu, D., Mboera, L., Shayo, E. H., Mmbaga, B. T., Urassa, M., Musoke, D., Kapata, N., Ferrand, R. A., Kapata, P. C., Stigler, F., Czypionka, T., …McCoy, D. (2020). Lockdown measures in response to COVID-19 in nine sub-Saharan African countries. BMJ Global Health, 5(10), e003319

Lockdown measures have been introduced worldwide to contain the transmission of COVID-19. However, the term ‘lockdown’ is not well-defined. Indeed, WHO’s reference to ‘so-called lockdown measures’ indicates the absence of a clear and universally acce... Read More about Lockdown measures in response to COVID-19 in nine sub-Saharan African countries.

Classification of Intervertebral Disc Disease (2020)
Journal Article
Fenn, J., Olby, N. J., & The Canine Spinal Cord Injury Consortium (CANSORT-SCI). (2020). Classification of Intervertebral Disc Disease. Frontiers in Veterinary Science, 7, 579025

Intervertebral disc disease (IVDD) has been recognized in dogs since the 1800s, when the first descriptions of extruded disc material within the vertebral canal were published. In the intervening time our understanding of intervertebral disc patholog... Read More about Classification of Intervertebral Disc Disease.

Simvastatin Treatment Does Not Ameliorate Muscle Pathophysiology in a Mouse Model for Duchenne Muscular Dystrophy (2020)
Journal Article
Verhaart, I. E. C., Cappellari, O., Tanganyika-de Winter, C. L., Plomp, J. J., Nnorom, S., Wells, K. E., Hildyard, J. C. W., Bull, D., Aartsma-Rus, A., & Wells, D. J. (2020). Simvastatin Treatment Does Not Ameliorate Muscle Pathophysiology in a Mouse Model for Duchenne Muscular Dystrophy. Journal of Neuromuscular Diseases, 1-19

Duchenne muscular dystrophy is an X-linked, recessive muscular dystrophy in which the absence of the dystrophin protein leads to fibrosis, inflammation and oxidative stress, resulting in loss of muscle tissue. Drug repurposing, i.e. using drugs alrea... Read More about Simvastatin Treatment Does Not Ameliorate Muscle Pathophysiology in a Mouse Model for Duchenne Muscular Dystrophy.