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Dogs Don’t Die Just in Hot Cars—Exertional Heat-Related Illness (Heatstroke) Is a Greater Threat to UK Dogs (2020)
Journal Article
Hall, E. J., Carter, A. J., & O’Neill, D. G. (2020). Dogs Don’t Die Just in Hot Cars—Exertional Heat-Related Illness (Heatstroke) Is a Greater Threat to UK Dogs. Animals, 10(8), 1324. https://doi.org/10.3390/ani10081324

Heat-related illness will affect increasing numbers of dogs as global temperatures rise unless e↵ective mitigation strategies are implemented. This study aimed to identify the key triggers of heat-related illness in dogs and investigate canine risk f... Read More about Dogs Don’t Die Just in Hot Cars—Exertional Heat-Related Illness (Heatstroke) Is a Greater Threat to UK Dogs.

In vitro Anticoccidial Study of Oregano and Garlic Essential Oils and Effects on Growth Performance, Fecal Oocyst Output, and Intestinal Microbiota in vivo (2020)
Journal Article
Sidiropoulou, E., Skoufos, I., Marugan-Hernandez, V., Giannenas, I., Bonos, E., Aguiar-Martins, K., Lazari, D., Blake, D., & Tzora, A. (2020). In vitro Anticoccidial Study of Oregano and Garlic Essential Oils and Effects on Growth Performance, Fecal Oocyst Output, and Intestinal Microbiota in vivo. Frontiers in Veterinary Science, 7, https://doi.org/10.3389/fvets.2020.00420

This study investigated the in vitro effects of Greek oregano and garlic essential oils on inhibition of Eimeria parasites and their in vivo effects on production performance, intestinal bacteria counts, and oocyst output. An inhibition assay was per... Read More about In vitro Anticoccidial Study of Oregano and Garlic Essential Oils and Effects on Growth Performance, Fecal Oocyst Output, and Intestinal Microbiota in vivo.

Cas13b-dependent and Cas13b-independent RNA knockdown of viral sequences in mosquito cells following guide RNA expression (2020)
Journal Article
Tng, P. Y. L., Carabajal Paladino, L., Verkuijl, S. A. N., Purcell, J., Merits, A., Leftwich, P. T., Fragkoudis, R., Noad, R., & Alphey, L. (2020). Cas13b-dependent and Cas13b-independent RNA knockdown of viral sequences in mosquito cells following guide RNA expression. Communications Biology, 3(1), https://doi.org/10.1038/s42003-020-01142-6

Aedes aegypti and Aedes albopictus mosquitoes are vectors of the RNA viruses chikungunya (CHIKV) and dengue that currently have no specific therapeutic treatments. The
development of new methods to generate virus-refractory mosquitoes would be benef... Read More about Cas13b-dependent and Cas13b-independent RNA knockdown of viral sequences in mosquito cells following guide RNA expression.

Epidemiological and clinical characteristics of the COVID-19 epidemic in Brazil (2020)
Journal Article
de Souza, W. M., Buss, L. F., Candido, D. A., Carrera, J. P., Li, S., Zarebski, A. E., Pereira, R. H. M., Prete, C. A., de Souza-Santos, A. A., Parag, K. V., Belotti, M. C. T. D., Vincenti-Gonzalez, M. F., Messina, J., da Silva Sales, F. C., Andrade, P. S., Nascimento, V. H., Ghilardi, F., Abade, L., Gutierrez, B., Kraemer, M. U. G., …Faria, N. R. (2020). Epidemiological and clinical characteristics of the COVID-19 epidemic in Brazil. Nature Human Behaviour, 4(8), 856-865

The first case of COVID-19 was detected in Brazil on 25 February 2020. We report and contextualize epidemiological, demographic and clinical findings for COVID-19 cases during the first 3 months of the epidemic. By 31 May 2020, 514,200 COVID-19 cases... Read More about Epidemiological and clinical characteristics of the COVID-19 epidemic in Brazil.

Equine asthma: current understanding and future directions (2020)
Journal Article
Couetil, L., Cardwell, J., Leguillette, R., Mazan, M., Richard, E., Bienzle, D., Bullone, M., Gerber, V., Ivester, K., Lavoie, J., Martin, J., Moran, G., Niedźwiedź, A., Pusterla, N., & Swiderski, C. (2020). Equine asthma: current understanding and future directions. Frontiers in Veterinary Science, 7(450), 1-21. https://doi.org/10.3389/fvets.2020.00450

The 2019 Havemeyer Workshop brought together researchers and clinicians to discuss the latest information on Equine Asthma and provide future research directions. Current clinical and molecular asthma phenotypes and endotypes in humans were discussed... Read More about Equine asthma: current understanding and future directions.

Dimethyl-2-oxoglutarate improves redox balance and mitochondrial function in muscle pericytes of individuals with diabetes mellitus (2020)
Journal Article
Faulkner, A., Tamiato, A., Cathery, W., Rampin, A., Caravaggi, C. M., Jover, E., Allen, S., Mellor, H., Hauton, D., Heather, L. C., Spinetti, G., & Madeddu, P. (2020). Dimethyl-2-oxoglutarate improves redox balance and mitochondrial function in muscle pericytes of individuals with diabetes mellitus. Diabetologia, 63(10), 2205-2217

Aims/hypothesis Treatment of vascular complications of diabetes remains inadequate. We reported that muscle pericytes (MPs) from limb muscles of vascular patients with diabetes mellitus display elevated levels of oxidative stress causing a dysfunctio... Read More about Dimethyl-2-oxoglutarate improves redox balance and mitochondrial function in muscle pericytes of individuals with diabetes mellitus.

Possible Drivers of the 2019 Dengue Outbreak in Bangladesh: The Need for a Robust Community-Level Surveillance System (2020)
Journal Article
Ahsan, A., Haider, N., Kock, R., Benfield, C., & Reisen, W. (2020). Possible Drivers of the 2019 Dengue Outbreak in Bangladesh: The Need for a Robust Community-Level Surveillance System. Journal of Medical Entomology, https://doi.org/10.1093/jme/tjaa150

Bangladesh experienced its largest dengue virus (DENV) outbreak in 2019, with 101,354 patients admitted to hospital with either laboratory confirmed or clinical diagnosis. By contrast, the cumulative number of dengue patients admitted to hospitals in... Read More about Possible Drivers of the 2019 Dengue Outbreak in Bangladesh: The Need for a Robust Community-Level Surveillance System.

A history of antimicrobial drugs in animals: Evolution and revolution (2020)
Journal Article
Lees, P., Pelligand, L., Giraud, E., & Toutain, P. (2020). A history of antimicrobial drugs in animals: Evolution and revolution. Journal of Veterinary Pharmacology and Therapeutics, https://doi.org/10.1111/jvp.12895

The evolutionary process of antimicrobial drug (AMD) uses in animals over a mere eight decades (1940–2020) has led to a revolutionary outcome, and both evolution and revolution are ongoing, with reports on a range of uses, misuses and abuses escalati... Read More about A history of antimicrobial drugs in animals: Evolution and revolution.

Beyond banning wildlife trade: COVID-19, conservation and development (2020)
Journal Article
Roe, D., Dickman, A., Kock, R., Milner-Gulland, E., Rihoy, E., & ’t Sas-Rolfes, M. (2020). Beyond banning wildlife trade: COVID-19, conservation and development. World Development, 136, 105121. https://doi.org/10.1016/j.worlddev.2020.105121

One of the immediate responses to COVID-19 has been a call to ban wildlife trade given the suspected origin of the pandemic in a Chinese market selling and butchering wild animals. There is clearly an urgent need to tackle wildlife trade that is ille... Read More about Beyond banning wildlife trade: COVID-19, conservation and development.

Knowledge, Attitudes and Practices of Veterinarians Towards Antimicrobial Resistance and Stewardship in Nigeria (2020)
Journal Article
Adekanye, U., Ekiri, A., Galipó, E., Muhammad, A., Mateus, A., La Ragione, R., Wakawa, A., Armson, B., Mijten, E., Alafiatayo, R., Varga, G., & Cook, A. (2020). Knowledge, Attitudes and Practices of Veterinarians Towards Antimicrobial Resistance and Stewardship in Nigeria. Antibiotics, https://doi.org/10.3390/antibiotics9080453

Abstract: Antimicrobial resistance (AMR) is a global health concern and the inappropriate use of antibiotics in animals and humans are considered contributing factors. A cross-sectional survey to assess the knowledge, attitudes and practices of veter... Read More about Knowledge, Attitudes and Practices of Veterinarians Towards Antimicrobial Resistance and Stewardship in Nigeria.

Dual neutralisation of IL-17F and IL-17A with bimekizumab blocks inflammation-driven osteogenic differentiation of human periosteal cells (2020)
Journal Article
Shah, M., Maroof, A., Gikas, P., Mittal, G., Keen, R., Baeten, D., Shaw, S., & Roberts, S. J. (2020). Dual neutralisation of IL-17F and IL-17A with bimekizumab blocks inflammation-driven osteogenic differentiation of human periosteal cells. RMD Open, 6(2), e001306. https://doi.org/10.1136/rmdopen-2020-001306

Objectives
Interleukin (IL)-17 signalling has been shown to be a key regulator of disease in ankylosing spondylitis (AS) with several IL-17 blockers currently clinically approved. Despite this, the role of IL-17 in bone pathology is poorly understo... Read More about Dual neutralisation of IL-17F and IL-17A with bimekizumab blocks inflammation-driven osteogenic differentiation of human periosteal cells.

Echocardiographic, morphometric and biomarker changes in female cats followed from 6 to 24 months of life (2020)
Journal Article
van Hoek, I., Laxalde, J., Connolly, D., Rush, J., & Freeman, L. (2020). Echocardiographic, morphometric and biomarker changes in female cats followed from 6 to 24 months of life. Journal of Feline Medicine and Surgery, 1098612X2094368. https://doi.org/10.1177/1098612X20943684

Objectives
The aim of the study was to evaluate cardiac size and early growth through echocardiographic, bodyweight (BW), body condition score (BCS), morphometric and biomarker changes in cats followed from 6 to 24 months of age.

Methods
Twenty-... Read More about Echocardiographic, morphometric and biomarker changes in female cats followed from 6 to 24 months of life.

Prognostic factors and proposed grading system for cutaneous and subcutaneous soft tissue sarcomas in cats, based on a retrospective study (2020)
Journal Article
Dobromylskyj, M. J., Richards, V., & Smith, K. C. (2020). Prognostic factors and proposed grading system for cutaneous and subcutaneous soft tissue sarcomas in cats, based on a retrospective study. Journal of Feline Medicine and Surgery, 1098612X2094239. https://doi.org/10.1177/1098612x20942393

Objectives
The objectives of this study included utilising a large database from a diagnostic laboratory to identify any breed, sex or age predilections for cutaneous and subcutaneous soft tissue sarcomas (STSs), and the most common anatomical locat... Read More about Prognostic factors and proposed grading system for cutaneous and subcutaneous soft tissue sarcomas in cats, based on a retrospective study.

Prednisolone-induced diabetes mellitus in the cat: a historical cohort (2020)
Journal Article
Nerhagen, S., Moberg, H., Boge, G., & Glanemann, B. (2020). Prednisolone-induced diabetes mellitus in the cat: a historical cohort. Journal of Feline Medicine and Surgery, 1098612X2094352. https://doi.org/10.1177/1098612x20943522

Objectives
Prednisolone is a commonly used drug in cats and potential adverse effects include hyperglycaemia and diabetes mellitus. The aims of this study were to evaluate the frequency and investigate potential predisposing risk factors for the dev... Read More about Prednisolone-induced diabetes mellitus in the cat: a historical cohort.

Investigation of correlations between clinical signs and pathological findings in cats and dogs with inflammatory bowel disease (2020)
Journal Article
Farray, D., Rodriguez, F., Ravelo-Garcìa, A., Suarez-Bonne, A., Francisco-Arteaga, C., & Jaber, J. R. (2020). Investigation of correlations between clinical signs and pathological findings in cats and dogs with inflammatory bowel disease

This paper compares the correlation between the clinical signs and the histopathological observations of the entire intestine in cats and dogs with inflammatory bowel disease (IBD). To perform this study, hospital records of 53 dogs and 20 cats of di... Read More about Investigation of correlations between clinical signs and pathological findings in cats and dogs with inflammatory bowel disease.

Moxidectin: an oral treatment for human onchocerciasis (2020)
Journal Article
Milton, P., Hamley, J., Walker, M., & Basáñez, M. (2020). Moxidectin: an oral treatment for human onchocerciasis. Expert Review of Anti-infective Therapy, 1-15. https://doi.org/10.1080/14787210.2020.1792772

Moxidectin is a milbemycin endectocide recently approved for the treatment of human onchocerciasis. Onchocerciasis, earmarked for elimination of transmission, is a filarial infection endemic in Africa, Yemen, and the Amazonian focus straddling Venezu... Read More about Moxidectin: an oral treatment for human onchocerciasis.

Presumed generalised seizure following caudal epidural administration of morphine and detomidine in a pony (2020)
Journal Article
Tallon, R., McMillan, M., Ho, N., & Dunkel, B. (2020). Presumed generalised seizure following caudal epidural administration of morphine and detomidine in a pony. Equine Veterinary Education, https://doi.org/10.1111/eve.13342

A 9‐year‐old show pony mare became acutely lame following removal of a bone sequestrum of the distal phalanx of the right thoracic limb. The mare also suffered from ongoing right dorsal colitis secondary to previous long‐term nonsteroidal anti‐inflam... Read More about Presumed generalised seizure following caudal epidural administration of morphine and detomidine in a pony.

The Tumor Suppressor CYLD Inhibits Mammary Epithelial to Mesenchymal Transition by the Coordinated Inhibition of YAP/TAZ and TGFβ Signaling (2020)
Journal Article
Pseftogas, A., Xanthopoulos, K., Poutahidis, T., Ainali, C., Dafou, D., Panteris, E., Kern, J., Varelas, X., Hardas, A., Gonidas, C., Tsingotjidou, A., Hatzivassiliou, E., & Mosialos, G. (2020). The Tumor Suppressor CYLD Inhibits Mammary Epithelial to Mesenchymal Transition by the Coordinated Inhibition of YAP/TAZ and TGFβ Signaling. Cancers, 12(8), 2047. https://doi.org/10.3390/cancers12082047

Downregulation of the cylindromatosis (CYLD) tumor suppressor has been associated with breast cancer development and progression. Here, we report a critical role for CYLD in maintaining the phenotype of mammary epithelial cells in vitro and in vivo.... Read More about The Tumor Suppressor CYLD Inhibits Mammary Epithelial to Mesenchymal Transition by the Coordinated Inhibition of YAP/TAZ and TGFβ Signaling.