Simvastatin treatment prolongs the survival of scrapie-infected mice
Journal Article
Kempster, S., Bate, C., & Williams, A. Simvastatin treatment prolongs the survival of scrapie-infected mice. NeuroReport, 18(5), 479-482
Outputs (130)
Canine DLA diversity: 3. Disease studies
Presentation / Conference Contribution
Kennedy, L. J., Barnes, A., Short, A., Brown, J. J., Seddon, J., Fleeman, L., Brkljacic, M., Happ, G. M., Catchpole, B., & Ollier, W. E. R. Canine DLA diversity: 3. Disease studies
Statins reduce the neurotoxicity of platelet-activating factor
Journal Article
Bate, C., Rumbold, L., & Williams, A. Statins reduce the neurotoxicity of platelet-activating factor
The proteome of Toxoplasma gondii: integration with the genome provides novel insights into gene expression and annotation
Journal Article
Xia, D., Sanderson, S. J., Jones, A. R., Prieto, J. H., Yates, J. R., Bromley, E., Tomley, F. M., Lal, K., Sinden, R. E., Brunk, B. P., Roos, D. S., & Wastling, J. M. The proteome of Toxoplasma gondii: integration with the genome provides novel insights into gene expression and annotation. Genome Biology, 9(7), R116. https://doi.org/10.1186/gb-2008-9-7-r116
Microneme proteins in apicomplexans
Book Chapter
Carruthers, V. B., & Tomley, F. M. Microneme proteins in apicomplexans.
Characterization of the fine specificity of bovine CD8+ T cell responses to defined antigens from the protozoan parasite Theileria parva
Journal Article
Graham, S. P., Pellé, R., Yamage, M., Mwangi, D. M., Honda, Y., Mwakubambanya, R. S., De Villiers, E. P., Abuya, E., Awino, E., Gachanja, J., Mbwika, F., Muthiani, A. M., Muriuki, C., Nyanjui, J. K., Onono, F. O., Osaso, J., Riitho, V., Saya, R. M., Ellis, S. A., McKeever, D. J., …Taracha, E. L. N. Characterization of the fine specificity of bovine CD8+ T cell responses to defined antigens from the protozoan parasite Theileria parva. Infection and Immunity, 76(2), 685-694. https://doi.org/10.1128/IAI.01244-07
Determining the protein repertoire of Cryptosporidium parvum sporozoites. Proteomics
Journal Article
Sanderson, S. J., Xia, D., Prieto, H., Yates, J., Heiges, M., Kissinger, J. C., Bromley, E., Lal, K., Sinden, R. E., Tomley, F. M., & Wastling, J. M. Determining the protein repertoire of Cryptosporidium parvum sporozoites. Proteomics. Proteomics, 8(7), 1398-414. https://doi.org/10.1002/pmic.200700804
Complete NMR assignments for the second microneme adhesive repeat (MAR) domain from Eimeria tenella microneme protein EtMIC3
Journal Article
Lai, L., Simpson, P., Burnstead, J., Tomley, F. M., & Matthews, S. Complete NMR assignments for the second microneme adhesive repeat (MAR) domain from Eimeria tenella microneme protein EtMIC3. Biomolecular NMR Assignments, 3(2), 175-7. https://doi.org/10.1007/s12104-009-9168-2
Proteomic comparison of four Eimeria tenella life-cycle stages: unsporulated oocyst, sporulated oocyst, sporozoite and second-generation merozoite
Journal Article
Lal, K., Bromley, E., Oakes, R. D., Prieto, J. H., Sanderson, S. J., Kurian, D., Hunt, L., Yates, J. R., Wastling, J. M., Sinden, R. E., & Tomley, F. M. Proteomic comparison of four Eimeria tenella life-cycle stages: unsporulated oocyst, sporulated oocyst, sporozoite and second-generation merozoite. Proteomics, 9(19), 4566-76. https://doi.org/10.1002/pmic.200900305
Characterisation of Plasmodium invasive organelles; an ookinete microneme proteome
Journal Article
Lal, K., Prieto, J. H., Bromley, E., Sanderson, S. J., Yates, J. R. 3., Wastling, J. M., Tomley, F. M., & Sinden, R. E. Characterisation of Plasmodium invasive organelles; an ookinete microneme proteome. Proteomics, 9(5), 1142-51. https://doi.org/10.1002/pmic.200800404
CD8+ T-cell responses to Theileria parva are preferentially directed to a single dominant antigen: Implications for parasite strain-specific immunity
Journal Article
MacHugh, N. D., Connelly, T., Graham, S. P., Pelle, R., Formisano, P., Taracha, E. L., Ellis, S. A., McKeever, D. J., Burrells, A., & Morrison, W. CD8+ T-cell responses to Theileria parva are preferentially directed to a single dominant antigen: Implications for parasite strain-specific immunity. European Journal of Immunology, 39(9), 1-11. https://doi.org/10.1002/eji.200939227
Expression analysis of the Theileria parva subtelomere-encoded variable secreted protein gene family
Journal Article
Schmuckli-Maurer, J., Casanova, C., Schmied, S., Affentranger, S., Parvanova, I., Kang'A, S., Nene, V., Katzer, F., McKeever, D. J., Müller, J., Bishop, R., Pain, A., & Dobbelaere, D. Expression analysis of the Theileria parva subtelomere-encoded variable secreted protein gene family. PLoS ONE, 4(3), e4839. https://doi.org/10.1371/journal.pone.0004839
Livestock infectious diseases and zoonoses
Journal Article
Tomley, F. M., & Shirley, M. W. Livestock infectious diseases and zoonoses. Philosophical Transactions of the Royal Society B: Biological Sciences, 364(1530), 2637-42. https://doi.org/10.1098/rstb.2009.0133
LIPID RAFTS, CELL SIGNALLING, PRION FORMATION AND NEURODEGENERATION IN PRION DISEASES
Presentation / Conference Contribution
Williams, A., & Bate, C. LIPID RAFTS, CELL SIGNALLING, PRION FORMATION AND NEURODEGENERATION IN PRION DISEASES
MORN1 has a conserved role in asexual and sexual development across the apicomplexa. Eukaryot Cell
Journal Article
Ferguson, D. J. P., Sahoo, N., Pinches, R. A., Bumstead, J. M., Tomley, F. M., & Gubbels, M. J. (in press). MORN1 has a conserved role in asexual and sexual development across the apicomplexa. Eukaryot Cell. https://doi.org/10.1128/EC.00021-08The gene encoding the membrane occupation and recognition nexus protein MORN1 is conserved across the Apicomplexa. In Toxoplasma gondii, MORN1 is associated with the spindle poles, the anterior and posterior rings of the inner membrane complex (IMC).... Read More about MORN1 has a conserved role in asexual and sexual development across the apicomplexa. Eukaryot Cell.
Do prion-induced changes in cholesterol trigger neurodegeneration?
Journal Article
Bate, C., & Williams, A. Do prion-induced changes in cholesterol trigger neurodegeneration?. Future Neurology, 3(4), 367-370. https://doi.org/10.2217/14796708.3.4.367
Sequestration of free cholesterol in cell membranes by prions correlates with cytoplasmic phospholipase A(2) activation
Journal Article
Bate, C., Tayebi, M., & Williams, A. Sequestration of free cholesterol in cell membranes by prions correlates with cytoplasmic phospholipase A(2) activation. BMC Biology, 6, https://doi.org/10.1186/1741-7007-6-8Background: The transmissible spongiform encephalopathies (TSEs), otherwise known as the prion diseases, occur following the conversion of the normal cellular prion protein ( PrPC) to an alternatively folded isoform ( PrPSc). The accumulation of PrPS... Read More about Sequestration of free cholesterol in cell membranes by prions correlates with cytoplasmic phospholipase A(2) activation.
Ginkgolides protect against amyloid-beta(1-42)-mediated synapse damage in vitro
Journal Article
Bate, C., Tayebi, M., & Williams, A. Ginkgolides protect against amyloid-beta(1-42)-mediated synapse damage in vitro. Molecular Neurodegeneration, 3(1), https://doi.org/10.1186/1750-1326-3-1
Docosahexaenoic and eicosapentaenoic acids increase prion formation in neuronal cells
Journal Article
Bate, C., Tayebi, M., Diomede, L., Salmona, M., & Williams, A. Docosahexaenoic and eicosapentaenoic acids increase prion formation in neuronal cells. BMC Biology, 6, https://doi.org/10.1186/1741-7007-6-39Background: The transmissible spongiform encephalopathies, otherwise known as prion diseases, occur following the conversion of the cellular prion protein (PrPC) to an alternatively folded, disease-associated isoform (PrPSc). Recent studies suggest t... Read More about Docosahexaenoic and eicosapentaenoic acids increase prion formation in neuronal cells.
Genetic and proteomic analysis of the MHC class I repertoire from four ovine haplotypes
Journal Article
Ballingall, K. T., Miltiadou, D., Chai, Z. W., McLean, K., Rocchi, M., Yaga, R., & McKeever, D. J. Genetic and proteomic analysis of the MHC class I repertoire from four ovine haplotypes. Immunogenetics, 60(3-4), 177-184. https://doi.org/10.1007/s00251-008-0276-4