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Outputs (138)

Demographic History, Adaptation, and NRAP Convergent Evolution at Amino Acid Residue 100 in the World Northernmost Cattle from Siberia (2021)
Journal Article
Buggiotti, L., Yurchenko, A. A., Yudin, N. S., Jagt, C. J. V., Vorobieva, N. V., Kusliy, M. F., Vasiliev, S. K., Rodionov, A. N., Boronetskaya, O. I., Zinovieva, N. A., Graphodatsky, A. S., Daetwyler, H. D., & Larkin, D. M. (2021). Demographic History, Adaptation, and NRAP Convergent Evolution at Amino Acid Residue 100 in the World Northernmost Cattle from Siberia. Molecular Biology and Evolution,

Native cattle breeds represent an important cultural heritage. They are a reservoir of genetic variation useful for properly responding to agriculture needs in the light of ongoing climate changes. Evolutionary processes that occur in response to ext... Read More about Demographic History, Adaptation, and NRAP Convergent Evolution at Amino Acid Residue 100 in the World Northernmost Cattle from Siberia.

Frequency, breed predisposition and demographic risk factors for overweight status in dogs in the UK (2021)
Journal Article
Pegram, C., Raffan, E., White, E., Ashworth, A., Brodbelt, D., Church, D., & O'Neill, D. (2021). Frequency, breed predisposition and demographic risk factors for overweight status in dogs in the UK. Journal of Small Animal Practice, https://doi.org/10.1111/jsap.13325

Objectives: To evaluate the prevalence and risk factors for overweight status in dogs under primary veterinary care in the UK.
Methods: A retrospective study design was used to estimate the one-year (2016) period prevalence of overweight status. The... Read More about Frequency, breed predisposition and demographic risk factors for overweight status in dogs in the UK.

Global network analysis in Schizosaccharomyces pombe reveals three distinct consequences of the common 1-kb deletion causing juvenile CLN3 disease (2021)
Journal Article
Russell, C., Minnis, C. J., Townsend, S., Petschnigg, J., Tinelli, E., Bähler, J., Russell, C., & Mole, S. E. (2021). Global network analysis in Schizosaccharomyces pombe reveals three distinct consequences of the common 1-kb deletion causing juvenile CLN3 disease. Scientific Reports,

Juvenile CLN3 disease is a recessively inherited paediatric neurodegenerative disorder, with most patients homozygous for a 1-kb intragenic deletion in CLN3. The btn1 gene is the Schizosaccharomyces pombe orthologue of CLN3. Here, we have extended th... Read More about Global network analysis in Schizosaccharomyces pombe reveals three distinct consequences of the common 1-kb deletion causing juvenile CLN3 disease.

A Grand Challenge for Animal Science: Multiple Goals – Convergent and Divergent (2021)
Journal Article
Nicol, C. (2021). A Grand Challenge for Animal Science: Multiple Goals – Convergent and Divergent. Frontiers in Animal Science, 2, https://doi.org/10.3389/fanim.2021.640503

People want safe, affordable, high quality animal-derived foods, produced in ways that protect rural livelihoods and cultures and which are derived from animals that lived healthy and happy lives. These aspirations must be set alongside the overarchi... Read More about A Grand Challenge for Animal Science: Multiple Goals – Convergent and Divergent.

Sensitivity of the Natriuretic Peptide/cGMP System to Hyperammonaemia in Rat C6 Glioma Cells and GPNT Brain Endothelial Cells (2021)
Journal Article
Regan, J., Mirczuk, S., Scudder, C., Stacey, E., Khan, S., Powles, T., Dennis-Berron, J. S., Ginley-Hidinger, M., Mcgonnell, I., Volk, H., Strickland, R., Tivers, M., Lawson, C., Lipscomb, V., & Fowkes, R. (2021). Sensitivity of the Natriuretic Peptide/cGMP System to Hyperammonaemia in Rat C6 Glioma Cells and GPNT Brain Endothelial Cells. Cells, https://doi.org/10.3390/cells10020398

C-type natriuretic peptide (CNP) is the major natriuretic peptide of the central nervous system and acts via its selective guanylyl cyclase-B (GC-B) receptor to regulate cGMP production in neurons, astrocytes and endothelial cells. CNP is implicated... Read More about Sensitivity of the Natriuretic Peptide/cGMP System to Hyperammonaemia in Rat C6 Glioma Cells and GPNT Brain Endothelial Cells.

Pituitary Neoplasm Nomenclature Workshop: Does Adenoma Stand the Test of Time? (2021)
Journal Article
Ho, K., Fleseriu, M., Kaiser, U., Salvatori, R., Brue, T., Lopes, M. B., Kunz, P., Molitch, M., Camper, S. A., Gadelha, M., Syro, L. V., Laws, E., Reincke, M., Nishioka, H., Grossman, A., Barkan, A., Casanueva, F., Wass, J., Mamelak, A., Katznelson, L., …Melmed, S. (2021). Pituitary Neoplasm Nomenclature Workshop: Does Adenoma Stand the Test of Time?. Journal of the Endocrine Society, 5(3), https://doi.org/10.1210/jendso/bvaa205

The WHO Classification of Endocrine Tumours designates pituitary neoplasms as adenomas. A proposed nomenclature change to pituitary neuroendocrine tumors (PitNETs) has been met with concern by some stakeholder groups. The Pituitary Society coordinate... Read More about Pituitary Neoplasm Nomenclature Workshop: Does Adenoma Stand the Test of Time?.

Systematic analysis reveals that colony housing aligns gait profiles and strengthens link between 1 histological and micro-CT bone markers in rat models of osteoarthritis 2 Short running title: Colony housing strengthens osteoarthritis research (2021)
Journal Article
Chang, Y.-M., Menges, S., Westhof, A., Kleinschmidt-Doerr, K., Brenneis, C., Pitsillides, A. A., & Chang, Y.-M. (in press). Systematic analysis reveals that colony housing aligns gait profiles and strengthens link between 1 histological and micro-CT bone markers in rat models of osteoarthritis 2 Short running title: Colony housing strengthens osteoarthritis research. FASEB Journal, -. https://doi.org/10.1096/fj.202002009R

The role of mitochondria in cocaine addiction (2021)
Journal Article
Thornton, C., Grad, E., & Yaka, R. (in press). The role of mitochondria in cocaine addiction. Biochemical Journal,

The incidence of cocaine abuse is increasing especially in the UK where the rates are among the highest in Europe. In addition to its role as a psychostimulant, cocaine has profound effect on brain metabolism, impacting glycolysis and impairing oxida... Read More about The role of mitochondria in cocaine addiction.

Natriuretic peptide expression and function in GH3 somatolactotropes and feline somatotrope pituitary tumors (2021)
Journal Article
Mirczuk, S., Scudder, C., Read, J., Crossley, V., Regan, J., Richardson, K., Simbi, B., Mcardle, C., Church, D., Fenn, J., Kenny, P., Volk, H., Wheeler-Jones, C., Korbonits, M., Niessen, S., Mcgonnell, I., & Fowkes, R. (2021). Natriuretic peptide expression and function in GH3 somatolactotropes and feline somatotrope pituitary tumors. International Journal of Molecular Sciences, -. https://doi.org/10.3390/ijms22031076

Patients harbouring mutations in genes encoding C-type natriuretic peptide (CNP; NPPC) or its receptor guanylyl cyclase B (GC-B, NPR2) suffer from severe growth phenotypes; loss-of-function mutations cause achondroplasia, whereas gain-of-function mut... Read More about Natriuretic peptide expression and function in GH3 somatolactotropes and feline somatotrope pituitary tumors.

Emerging Roles for Neuropilin-2 in Cardiovascular Disease (2020)
Journal Article
Harman, J. L., Sayers, J., Chapman, C., & Pellet-Many, C. (2020). Emerging Roles for Neuropilin-2 in Cardiovascular Disease. International Journal of Molecular Sciences, 21(14), 5154. https://doi.org/10.3390/ijms21145154

Cardiovascular disease, the leading cause of death worldwide, is predominantly associated with atherosclerosis. Atherosclerosis is a chronic inflammatory disease characterised by the narrowing of large to medium-sized arteries due to a build-up of pl... Read More about Emerging Roles for Neuropilin-2 in Cardiovascular Disease.

Microporous Biodegradable Films Promote Therapeutic Angiogenesis (2020)
Journal Article
Hendow, E., Moazen, M., Iacoviello, F., Bozec, L., Pellet‐Many, C., & Day, R. (2020). Microporous Biodegradable Films Promote Therapeutic Angiogenesis. Advanced Healthcare Materials, 2000806

Peripheral arterial disease and critical limb ischemia are common symptoms of cardiovascular disease. Vascular surgery is used to create a bypass around occluded blood vessels to improve blood flow to ischemic muscle, thus avoiding the need for amput... Read More about Microporous Biodegradable Films Promote Therapeutic Angiogenesis.

Determinants of diarrhoeal diseases and height-for-age z-scores in children under five years of age in rural central Tanzania (2020)
Journal Article
Kock, R. (2020). Determinants of diarrhoeal diseases and height-for-age z-scores in children under five years of age in rural central Tanzania. Open Journal of Preventive Medicine, https://doi.org/10.15167/2421-4248/jpmh2020.61.3.1486

Introduction. Childhood diarrhoeal diseases and stunting are
major health problems in low- and middle-income countries
(LMICs). Poor water supply, sanitation services and hygiene,
frequently encountered in resource-poor settings, contribute to
ch... Read More about Determinants of diarrhoeal diseases and height-for-age z-scores in children under five years of age in rural central Tanzania.

Neuropilin 1 mediates epicardial activation and revascularization in the regenerating zebrafish heart (2019)
Journal Article
Lowe, V., Wisniewski, L., Sayers, J., Evans, I., Frankel, P., Mercader-Huber, N., Zachary, I. C., & Pellet-Many, C. (2019). Neuropilin 1 mediates epicardial activation and revascularization in the regenerating zebrafish heart. Development, 146, https://doi.org/10.1242/dev.174482

Unlike adult mammals, zebrafish can regenerate their heart. A key mechanism for regeneration is the activation of the epicardium, leading to the establishment of a supporting scaffold for new cardiomyocytes, angiogenesis and cytokine secretion. Neuro... Read More about Neuropilin 1 mediates epicardial activation and revascularization in the regenerating zebrafish heart.