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Emerging Roles for Neuropilin-2 in Cardiovascular Disease

Harman, J L; Sayers, J; Chapman, C; Pellet-Many, C

Authors

J L Harman

J Sayers

C Chapman

C Pellet-Many



Abstract

Cardiovascular disease, the leading cause of death worldwide, is predominantly associated with atherosclerosis. Atherosclerosis is a chronic inflammatory disease characterised by the narrowing of large to medium-sized arteries due to a build-up of plaque. Atherosclerotic plaque is comprised of lipids, extracellular matrix, and several cell types, including endothelial, immune, and vascular smooth muscle cells. Such narrowing of the blood vessels can itself restrict blood flow to vital organs but most severe clinical complications, including heart attacks and strokes, occur when lesions rupture, triggering the blood to clot and obstructing blood flow further down the vascular tree. To circumvent such obstructions, percutaneous coronary intervention or bypass grafts are often required; however, re-occlusion of the treated artery frequently occurs. Neuropilins (NRPs), a multifunctional family of cell surface co-receptors, are expressed by endothelial, immune, and vascular smooth muscle cells and are regulators of numerous signalling pathways within the vasculature. Here, we review recent studies implicating NRP2 in the development of occlusive vascular diseases and discuss how NRP2 could be targeted for therapeutic intervention.

Citation

Harman, J. L., Sayers, J., Chapman, C., & Pellet-Many, C. (2020). Emerging Roles for Neuropilin-2 in Cardiovascular Disease. International Journal of Molecular Sciences, 21(14), 5154. https://doi.org/10.3390/ijms21145154

Journal Article Type Article
Acceptance Date Jul 17, 2020
Publication Date Jul 21, 2020
Deposit Date Sep 8, 2020
Publicly Available Date Sep 8, 2020
Journal International Journal of Molecular Sciences
Print ISSN 1661-6596
Publisher MDPI
Peer Reviewed Peer Reviewed
Volume 21
Issue 14
Pages 5154
DOI https://doi.org/10.3390/ijms21145154
Public URL https://rvc-repository.worktribe.com/output/1376766
Publisher URL https://doi.org/10.3390/ijms21145154

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