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The zebrafish cardiac endothelial cell – roles in development and regeneration

Pellet-Many, Caroline; Lowe, Vanessa; Wisniewski, Laura


Caroline Pellet-Many

Vanessa Lowe

Laura Wisniewski


In zebrafish, the spatiotemporal development of the vascular system is well described due to its stereotypical nature. However, the cellular and molecular mechanisms orchestrating post embryonic vascular development, the maintenance of vascular homeostasis or how coronary vessels integrate into the growing heart are less well studied.
In the context of cardiac regeneration, if the central cellular mechanism by which the heart regenerates a fully functional myocardium relies on the proliferation of pre-existing cardiomyocytes, the epicardium and the endocardium are also known to play key roles in the regenerative process. Remarkably, revascularisation of the injured tissue occurs within a few hours after cardiac damage, thus generating a vascular network acting as a scaffold for the regenerating myocardium. The activation of the endocardium leads to the secretion of cytokines, further supporting the proliferation of the cardiomyocytes.
Although epicardium, endocardium and myocardium interact with each other to orchestrate heart development and regeneration, in this review, we will be focussing on recent advancements in the understanding of the development of the endocardium and the coronary vasculature in zebrafish as well as their pivotal roles in the heart regeneration process.


Pellet-Many, C., Lowe, V., & Wisniewski, L. (2021). The zebrafish cardiac endothelial cell – roles in development and regeneration. Journal of Cardiovascular Development and Disease,

Journal Article Type Review
Acceptance Date Apr 13, 2021
Publication Date May 1, 2021
Deposit Date Feb 23, 2021
Publicly Available Date May 5, 2021
Publisher MDPI
Peer Reviewed Peer Reviewed
Issue Zebrafish Heart Development, Regeneration, and Disease Modelling
Series Title Zebrafish Heart Development, Regeneration, and Disease Modelling
Keywords zebrafish, heart, regeneration, development, coronary vessels, endocardium, lymphatics.
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