Microporous Biodegradable Films Promote Therapeutic Angiogenesis

Hendow, EK; Moazen, M; Iacoviello, F; Bozec, L; Pellet?Many, C; Day, RM

Abstract

Peripheral arterial disease and critical limb ischemia are common symptoms of cardiovascular disease. Vascular surgery is used to create a bypass around occluded blood vessels to improve blood flow to ischemic muscle, thus avoiding the need for amputation. Attempts to vascularize tissues by therapeutic angiogenesis using delivery of exogenous angiogenic agents are underwhelming. A material-based approach that provides an endogenous stimulus capable of promoting angiogenesis and increased tissue perfusion would provide a paradigm shift in treatment options available. It is reported here that microporous biodegradable films produced using thermally induced phase separation provide a localized biophysical stimulus of proangiogenic genes in vivo that is associated with increased blood vessel density and restoration of blood flow to ischemic tissue. These findings show, for the first time, that acellular, nonfunctionalized biodegradable biomaterials can provide an innovative, material-based approach for therapeutic angiogenesis to enhance tissue reperfusion in vivo.

Citation

Hendow, E., Moazen, M., Iacoviello, F., Bozec, L., Pellet‐Many, C., & Day, R. (2020). Microporous Biodegradable Films Promote Therapeutic Angiogenesis. Advanced Healthcare Materials, 2000806

• Journal Article Type: Article
• Acceptance Date: Jun 18, 2020
• Publication Date: Jul 14, 2020
• Deposit Date: Aug 27, 2020
• Publicly Available Date: Nov 20, 2020
• Journal: Advanced Healthcare Materials
• Print ISSN: 2192-2640
• Electronic ISSN: 2192-2659
• Publisher: Wiley-VCH Verlag
• Peer Reviewed: Peer Reviewed
• Pages: 2000806
• Public URL: https://rvc-repository.worktribe.com/output/1376853
• Publisher URL: https://doi.org/10.1002/adhm.202000806