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Microporous Biodegradable Films Promote Therapeutic Angiogenesis

Hendow, EK; Moazen, M; Iacoviello, F; Bozec, L; Pellet?Many, C; Day, RM

Authors

EK Hendow

M Moazen

F Iacoviello

L Bozec

C Pellet?Many

RM Day



Abstract

Peripheral arterial disease and critical limb ischemia are common symptoms of cardiovascular disease. Vascular surgery is used to create a bypass around occluded blood vessels to improve blood flow to ischemic muscle, thus avoiding the need for amputation. Attempts to vascularize tissues by therapeutic angiogenesis using delivery of exogenous angiogenic agents are underwhelming. A material-based approach that provides an endogenous stimulus capable of promoting angiogenesis and increased tissue perfusion would provide a paradigm shift in treatment options available. It is reported here that microporous biodegradable films produced using thermally induced phase separation provide a localized biophysical stimulus of proangiogenic genes in vivo that is associated with increased blood vessel density and restoration of blood flow to ischemic tissue. These findings show, for the first time, that acellular, nonfunctionalized biodegradable biomaterials can provide an innovative, material-based approach for therapeutic angiogenesis to enhance tissue reperfusion in vivo.

Citation

Hendow, E., Moazen, M., Iacoviello, F., Bozec, L., Pellet?Many, C., & Day, R. (2020). Microporous Biodegradable Films Promote Therapeutic Angiogenesis. Advanced Healthcare Materials, 2000806

Journal Article Type Article
Acceptance Date Jun 18, 2020
Publication Date Jul 14, 2020
Deposit Date Aug 27, 2020
Publicly Available Date Nov 20, 2020
Journal Advanced Healthcare Materials
Print ISSN 2192-2640
Publisher Wiley-VCH Verlag
Peer Reviewed Peer Reviewed
Pages 2000806
Public URL https://rvc-repository.worktribe.com/output/1376853
Publisher URL https://doi.org/10.1002/adhm.202000806

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