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Pituitary Neoplasm Nomenclature Workshop: Does Adenoma Stand the Test of Time?

Ho, Ken; Fleseriu, Maria; Kaiser, Ursula; Salvatori, Roberto; Brue, Thierry; Lopes, M Beatriz; Kunz, Pamela; Molitch, Mark; Camper, Sally A; Gadelha, Mônica; Syro, Luis V; Laws, Edward; Reincke, Martin; Nishioka, Hiroshi; Grossman, Ashley; Barkan, Ariel; Casanueva, Felipe; Wass, John; Mamelak, Adam; Katznelson, Laurence; van der Lely, Aart J; Radovick, Sally; Bidlingmaier, Martin; Boguszewski, Margaret; Bollerslev, Jens; Hoffman, Andrew R; Oyesiku, Nelson; Raverot, Gerald; Ben-Shlomo, Anat; Fowkes, Rob; Shimon, Ilan; Fukuoka, Hidenori; Pereira, Alberto M; Greenman, Yona; Heaney, Anthony P; Gurnell, Mark; Johannsson, Gudmundur; Osamura, Robert Y; Buchfelder, Michael; Zatelli, Maria Chiara; Korbonits, Marta; Chanson, Philippe; Biermasz, Nienke; Clemmons, David R; Karavitaki, Niki; Bronstein, Marcello D; Trainer, Peter; Melmed, Shlomo


Ken Ho

Maria Fleseriu

Ursula Kaiser

Roberto Salvatori

Thierry Brue

M Beatriz Lopes

Pamela Kunz

Mark Molitch

Sally A Camper

Mônica Gadelha

Luis V Syro

Edward Laws

Martin Reincke

Hiroshi Nishioka

Ashley Grossman

Ariel Barkan

Felipe Casanueva

John Wass

Adam Mamelak

Laurence Katznelson

Aart J van der Lely

Sally Radovick

Martin Bidlingmaier

Margaret Boguszewski

Jens Bollerslev

Andrew R Hoffman

Nelson Oyesiku

Gerald Raverot

Anat Ben-Shlomo

Rob Fowkes

Ilan Shimon

Hidenori Fukuoka

Alberto M Pereira

Yona Greenman

Anthony P Heaney

Mark Gurnell

Gudmundur Johannsson

Robert Y Osamura

Michael Buchfelder

Maria Chiara Zatelli

Marta Korbonits

Philippe Chanson

Nienke Biermasz

David R Clemmons

Niki Karavitaki

Marcello D Bronstein

Peter Trainer

Shlomo Melmed


The WHO Classification of Endocrine Tumours designates pituitary neoplasms as adenomas. A proposed nomenclature change to pituitary neuroendocrine tumors (PitNETs) has been met with concern by some stakeholder groups. The Pituitary Society coordinated the Pituitary Neoplasm Nomenclature (PANOMEN) workshop to address the topic. Experts in pituitary developmental biology, pathology, neurosurgery, endocrinology, and oncology, including representatives nominated by the Endocrine Society, European Society of Endocrinology, European Neuroendocrine Association, Growth Hormone Research Society, and International Society of Pituitary Surgeons. Clinical epidemiology, disease phenotype, management, and prognosis of pituitary adenomas differ from that of most NETs. The vast majority of pituitary adenomas are benign and do not adversely impact life expectancy. A nomenclature change to PitNET does not address the main challenge of prognostic prediction, assigns an uncertain malignancy designation to benign pituitary adenomas, and may adversely affect patients. Due to pandemic restrictions, the workshop was conducted virtually, with audiovisual lectures and written précis on each topic provided to all participants. Feedback was collated and summarized by Content Chairs and discussed during a virtual writing meeting moderated by Session Chairs, which yielded an evidence-based draft document sent to all participants for review and approval. There is not yet a case for adopting the PitNET nomenclature. The PANOMEN Workshop recommends that the term adenoma be retained and that the topic be revisited as new evidence on pituitary neoplasm biology emerges.


Ho, K., Fleseriu, M., Kaiser, U., Salvatori, R., Brue, T., Lopes, M. B., …Melmed, S. (2021). Pituitary Neoplasm Nomenclature Workshop: Does Adenoma Stand the Test of Time?. Journal of the Endocrine Society, 5(3),

Journal Article Type Article
Acceptance Date Feb 9, 2021
Online Publication Date Feb 9, 2021
Publication Date Mar 1, 2021
Deposit Date Feb 22, 2021
Publicly Available Date Feb 22, 2021
Journal Journal of the Endocrine Society
Print ISSN 2472-1972
Publisher Oxford University Press
Peer Reviewed Peer Reviewed
Volume 5
Issue 3
Public URL


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