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Demographic History, Adaptation, and NRAP Convergent Evolution at Amino Acid Residue 100 in the World Northernmost Cattle from Siberia

Buggiotti, Laura; Yurchenko, Andrey A; Yudin, Nikolay S; Jagt, Christy J Vander; Vorobieva, Nadezhda V; Kusliy, Mariya Ff; Vasiliev, Sergei K; Rodionov, Andrey N; Boronetskaya, Oksana I; Zinovieva, Natalia A; Graphodatsky, Alexander S; Daetwyler, Hans D; Larkin, Denis M


Laura Buggiotti

Andrey A Yurchenko

Nikolay S Yudin

Christy J Vander Jagt

Nadezhda V Vorobieva

Mariya Ff Kusliy

Sergei K Vasiliev

Andrey N Rodionov

Oksana I Boronetskaya

Natalia A Zinovieva

Alexander S Graphodatsky

Hans D Daetwyler

Denis M Larkin


Denis Larkin


Native cattle breeds represent an important cultural heritage. They are a reservoir of genetic variation useful for properly responding to agriculture needs in the light of ongoing climate changes. Evolutionary processes that occur in response to extreme environmental conditions could also be better understood using adapted local populations. Herein, different evolutionary histories of the world northernmost native cattle breeds from Russia were investigated. They highlighted Kholmogory as a typical taurine cattle, whereas Yakut cattle separated from European taurines approximately 5,000 years ago and contain numerous ancestral and some novel genetic variants allowing their adaptation to harsh conditions of living above the Polar Circle. Scans for selection signatures pointed to several common gene pathways related to adaptation to harsh climates in both breeds. But genes affected by selection from these pathways were mostly different. A Yakut cattle breed-specific missense mutation in a highly conserved NRAP gene represents a unique example of a young amino acid residue convergent change shared with at least 16 species of hibernating/cold-adapted mammals from six distinct phylogenetic orders. This suggests a convergent evolution event along the mammalian phylogenetic tree and fast fixation in a single isolated cattle population exposed to a harsh climate.


Buggiotti, L., Yurchenko, A. A., Yudin, N. S., Jagt, C. J. V., Vorobieva, N. V., Kusliy, M. F., …Larkin, D. M. (2021). Demographic History, Adaptation, and NRAP Convergent Evolution at Amino Acid Residue 100 in the World Northernmost Cattle from Siberia. Molecular Biology and Evolution,

Journal Article Type Article
Acceptance Date Mar 21, 2021
Publication Date Mar 30, 2021
Deposit Date Jul 4, 2021
Publicly Available Date Jul 14, 2021
Print ISSN 0737-4038
Publisher Oxford University Press
Peer Reviewed Peer Reviewed
Keywords cold adaptation; Yakut cattle; convergent evolution; NRAP; Kholmogory cattle; resequencing
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