L Buggiotti
Copy Number Variants in Two Northernmost Cattle Breeds Are Related to Their Adaptive Phenotypes
Buggiotti, L; Yudin, NS; Larkin, DM
Authors
NS Yudin
DM Larkin
Abstract
Copy number variations (CNVs) are genomic structural variants with potential functional and evolutionary effects on phenotypes. In this study, we report the identification and characterization of CNVs from the whole-genome resequencing data of two northernmost cattle breeds from Russia: the Yakut and Kholmogory cattle and their phylogenetically most related breeds, Hanwoo and Holstein, respectively. Comparisons of the CNV regions (CNVRs) among the breeds led to the identification of breed-specific CNVRs shared by cold-adapted Kholmogory and Yakut cattle. An investigation of their overlap with genes, regulatory domains, conserved non-coding elements (CNEs), enhancers, and quantitative trait loci (QTLs) was performed to further explore breed-specific biology and adaptations. We found CNVRs enriched for gene ontology terms related to adaptation to environments in both the Kholmogory and Yakut breeds and related to thermoregulation specifically in Yakut cattle. Interestingly, the latter has also been supported when exploring the enrichment of breed-specific CNVRs in the regulatory domains and enhancers, CNEs, and QTLs implying the potential contribution of CNVR to the Yakut and Kholmogory cattle breeds' adaptation to a harsh environment.
Citation
Buggiotti, L., Yudin, N., & Larkin, D. (2022). Copy Number Variants in Two Northernmost Cattle Breeds Are Related to Their Adaptive Phenotypes. Genes, 13(9), https://doi.org/10.3390/genes13091595
Journal Article Type | Article |
---|---|
Acceptance Date | Sep 2, 2022 |
Online Publication Date | Sep 6, 2022 |
Publication Date | 2022 |
Deposit Date | Aug 9, 2023 |
Publicly Available Date | Aug 9, 2023 |
Journal | Genes |
Electronic ISSN | 2073-4425 |
Publisher | MDPI |
Peer Reviewed | Peer Reviewed |
Volume | 13 |
Issue | 9 |
DOI | https://doi.org/10.3390/genes13091595 |
Keywords | CNV; cattle; cold adaptation; HISTORY; GENE; ADAPTATION; DIVERSITY; EVOLUTION; WHITE; COLOR |
Files
Copy Number Variants In Two Northernmost Cattle Breeds Are Related To Their Adaptive Phenotypes
(603 Kb)
PDF
Licence
http://creativecommons.org/licenses/by/4.0/
Publisher Licence URL
http://creativecommons.org/licenses/by/4.0/
Version
VoR
You might also like
Dinosaurs: Comparative Cytogenomics of Their Reptile Cousins and Avian Descendants
(2022)
Journal Article
Downloadable Citations
About RVC Repository
Administrator e-mail: publicationsrepos@rvc.ac.uk
This application uses the following open-source libraries:
SheetJS Community Edition
Apache License Version 2.0 (http://www.apache.org/licenses/)
PDF.js
Apache License Version 2.0 (http://www.apache.org/licenses/)
Font Awesome
SIL OFL 1.1 (http://scripts.sil.org/OFL)
MIT License (http://opensource.org/licenses/mit-license.html)
CC BY 3.0 ( http://creativecommons.org/licenses/by/3.0/)
Powered by Worktribe © 2025
Advanced Search