Altered Bone Mechanics, Architecture and Composition in the Skeleton of TIMP-3-Deficient Mice
(2017)
Journal Article
Miller, B., Spevak, L., Lukashova, L., Javaheri, B., Pitsillides, A. A., Boskey, A., …Carriero, A. (2017). Altered Bone Mechanics, Architecture and Composition in the Skeleton of TIMP-3-Deficient Mice. Calcified Tissue International, 100(6), 631–640. https://doi.org/10.1007/s00223-017-0248-5
The role of embryo movement in the development of the furcula (2017)
Journal Article
Pollard, A. S., Boyd, S., McGonnell, I. M., & Pitsillides, A. A. (2017). The role of embryo movement in the development of the furcula. Journal of Anatomy, 230(3), 435-443. https://doi.org/10.1111/joa.12571The pectoral girdle is a complex structure which varies in its morphology between species. A major component in birds is the furcula, which can be considered equivalent to a fusion of the paired clavicles found in many mammals, and the single intercl... Read More about The role of embryo movement in the development of the furcula.
Limb proportions show developmental plasticity in response to embryo movement (2017)
Journal Article
Pollard, A. S., Charlton, B. G., Hutchinson, J. R., Gustafsson, T., McGonnell, I. M., Timmons, J. A., & Pitsillides, A. A. (2017). Limb proportions show developmental plasticity in response to embryo movement. https://doi.org/10.1038/srep41926Animals have evolved limb proportions adapted to different environments, but it is not yet clear to what extent these proportions are directly influenced by the environment during prenatal development. The developing skeleton experiences mechanical l... Read More about Limb proportions show developmental plasticity in response to embryo movement.
Progressive Structural Defects in Canine Centronuclear Myopathy Indicate a Role for HACD1 in Maintaining Skeletal Muscle Membrane Systems (2017)
Journal Article
Walmsley, G. L., Blott, S., Venner, K., Sewry, C., Laport, J., Blondelle, J., …Piercy, R. J. (2017). Progressive Structural Defects in Canine Centronuclear Myopathy Indicate a Role for HACD1 in Maintaining Skeletal Muscle Membrane Systems. American Journal of Pathology, 187(2), 441-456. https://doi.org/10.1016/j.ajpath.2016.10.002Mutations in HACD1/PTPLA cause recessive congenital myopathies in humans and dogs. Hydroxyacyl-coA dehydratases are required for elongation of very long chain fatty acids, and HACD1 has a role in early myogenesis, but the functions of this striated m... Read More about Progressive Structural Defects in Canine Centronuclear Myopathy Indicate a Role for HACD1 in Maintaining Skeletal Muscle Membrane Systems.
An exploratory clustering approach for extracting stride parameters from tracking collars on free-ranging wild animals (2017)
Journal Article
Dewhirst, O. P., Roskilly, K., Hubel, T. Y., Jordan, N. R., Golabek, K. A., McNutt, J. W., & Wilson, A. M. (2017). An exploratory clustering approach for extracting stride parameters from tracking collars on free-ranging wild animals. Journal of Experimental Biology, 220(3), 341-346. https://doi.org/10.1242/jeb.146035
Neurons Responsive to Global Visual Motion Have Unique Tuning Properties in Hummingbirds (2017)
Journal Article
Gaede, A. H., Goller, B., Lam, J. P. M., Wylie, D. R., & Altshuler, D. L. (2017). Neurons Responsive to Global Visual Motion Have Unique Tuning Properties in Hummingbirds. Current Biology, 26(2), 279-285Neurons in animal visual systems that respond to global optic flow exhibit selectivity for motion direction and/or velocity. The avian lentiformis mesencephali (LM), known in mammals as the nucleus of the optic tract (NOT), is a key nucleus for glo... Read More about Neurons Responsive to Global Visual Motion Have Unique Tuning Properties in Hummingbirds.
Pathogenic LRRK2 variants are gain-of-function mutations that enhance LRRK2-mediated repression of beta-catenin signaling (2017)
Journal Article
Berwick, D. C., Javaheri, B., Wetzel, A., Hopkinson, M., Nixon-Abell, J., Granno, S., …Harvey, K. (2017). Pathogenic LRRK2 variants are gain-of-function mutations that enhance LRRK2-mediated repression of beta-catenin signaling. Molecular Neurodegeneration, 12(9), https://doi.org/10.1186/s13024-017-0153-4
Skeletal pathology and variable anatomy in elephant feet assessed using computed tomography (2017)
Journal Article
Regnault, S., Dixon, J. J., Warren-Smith, C., Hutchinson, J. R., & Weller, R. (2017). Skeletal pathology and variable anatomy in elephant feet assessed using computed tomography. https://doi.org/10.7717/peerj.2877
Endocranial Morphology of the Extinct North American Lion (Panthera atrox) (2017)
Journal Article
Cuff, A. R., Stockey, C., & Goswami, A. (2017). Endocranial Morphology of the Extinct North American Lion (Panthera atrox). https://doi.org/10.1159/000454705The extinct North American lion (Panthera atrox) is one of the largest felids (Mammalia, Carnivora) to have ever lived, and it is known from a plethora of incredibly well-preserved remains. Despite this abundance of material, there has been little re... Read More about Endocranial Morphology of the Extinct North American Lion (Panthera atrox).
Movement patterns of cheetahs ( Acinonyx jubatus ) in farmlands in Botswana (2017)
Journal Article
Van Der Weyde, L. K., Hubel, T. Y., Horgan, J., Shotton, J., McKenna, R., & Wilson, A. M. (2017). Movement patterns of cheetahs ( Acinonyx jubatus ) in farmlands in Botswana. Biology Open, 6, 118-124. https://doi.org/10.1242/bio.021055
Strain uses gap junctions to reverse stimulation of osteoblast proliferation by osteocytes (2017)
Journal Article
Suswillo, R. F. L., Javaheri, B., Rawlinson, S. C. F., Dowthwaite, G. P., Lanyon, L. E., & Pitsillides, A. A. (2017). Strain uses gap junctions to reverse stimulation of osteoblast proliferation by osteocytes. Cell Biochemistry and Function, 35(1), 56-65. https://doi.org/10.1002/cbf.3245
Petiolate wings: effects on the leading-edge vortex in flapping flight (2017)
Journal Article
Phillips, N., Knowles, K., & Bomphrey, R. J. (2017). Petiolate wings: effects on the leading-edge vortex in flapping flight. Interface Focus, 7(1),
Diversity in the organization of elastin bundles and intramembranous muscles in bat wings (2017)
Journal Article
Cheney, J. A., Allen, J. J., & Swartz, S. M. (2017). Diversity in the organization of elastin bundles and intramembranous muscles in bat wings. Journal of Anatomy, 230(5), 510-523. https://doi.org/10.1111/joa.12580
Sesamoid Bones in Tuatara (Sphenodon punctatus) Investigated With X-Ray Microtomography, and Implications for Sesamoid Evolution in Lepidosauria (2017)
Journal Article
Regnault, S., Hutchinson, J. R., & Jones, M. E. H. (2017). Sesamoid Bones in Tuatara (Sphenodon punctatus) Investigated With X-Ray Microtomography, and Implications for Sesamoid Evolution in Lepidosauria. Journal of Morphology, 278(1), 62-72. https://doi.org/10.1002/jmor.20619
Tumour-derived alkaline phosphatase regulates tumour growth, epithelial plasticity and disease-free survival in metastatic prostate cancer (2017)
Journal Article
Rao, S. R., Snaith, A. E., Marino, D., Cheng, X., Lwin, S. T., Orriss, I. R., …Edwards, C. M. (2017). Tumour-derived alkaline phosphatase regulates tumour growth, epithelial plasticity and disease-free survival in metastatic prostate cancer. British Journal of Cancer, 116, 227-236. https://doi.org/10.1038/bjc.2016.402
Sclerostin does not play a major role in the pathogenesis of skeletal complications in type 2 diabetes mellitus (2017)
Journal Article
Pereira, M., Gohin, S., Lund, N., Hvid, A., Smitham, P. J., Oddy, M. J., …Chenu, C. (2017). Sclerostin does not play a major role in the pathogenesis of skeletal complications in type 2 diabetes mellitus. Osteoporosis International, 28(1), 309-320. https://doi.org/10.1007/s00198-016-3718-0
A highly prevalent equine glycogen storage disease is explained by constitutive activation of a mutant glycogen synthase (2017)
Journal Article
Maile, C. A., Hingst, J. R., Mahalingan, K. K., O'Reilly, A. O., Cleasby, M. E., Mickelson, J. R., …Piercy, R. J. (2017). A highly prevalent equine glycogen storage disease is explained by constitutive activation of a mutant glycogen synthase. https://doi.org/10.1016/j.bbagen.2016.08.021
IMAGING DIAGNOSIS—IDIOPATHIC HYOID MALFORMATION IN AN 8‐YEAR‐OLD WELSH SECTION D HORSE (2017)
Journal Article
Dixon, J., Biggi, M., O'Brien, E. J. O., Farr, R., & Witte, T. H. (2017). IMAGING DIAGNOSIS—IDIOPATHIC HYOID MALFORMATION IN AN 8‐YEAR‐OLD WELSH SECTION D HORSE. Veterinary Radiology and Ultrasound, 58(1), E1-E5
Dmp1 Promoter-Driven Diphtheria Toxin Receptor Transgene Expression Directs Unforeseen Effects in Multiple Tissues (2017)
Journal Article
Al-Jazzar, A., Javaheri, B., Prideaux, M., Boyde, A., Scudamore, C. L., Cherifi, C., …Pitsillides, A. A. (2017). Dmp1 Promoter-Driven Diphtheria Toxin Receptor Transgene Expression Directs Unforeseen Effects in Multiple Tissues. International Journal of Molecular Sciences, 18(1), https://doi.org/10.3390/ijms18010029Mice harbouring a dentin matrix protein 1 (Dmp1) promoter-driven human diphtheria toxin (DT) receptor (HDTR) transgene (Tg) have recently been used to attain targeted ablation of osteocytes by diphtheria toxin (DT) treatment in order to define osteoc... Read More about Dmp1 Promoter-Driven Diphtheria Toxin Receptor Transgene Expression Directs Unforeseen Effects in Multiple Tissues.
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