Squalestatin cures prion-infected neurons and protects against prion neurotoxicity
Journal Article
Bate, C., Salmona, M., Diomede, L., & Williams, A. Squalestatin cures prion-infected neurons and protects against prion neurotoxicity. Journal of Biological Chemistry, 279(15), 14983-14990. https://doi.org/10.1074/jbc.M313061200
The role of platelet activating factor in prion and amyloid-beta neurotoxicity
Journal Article
Bate, C., Salmona, M., & Williams, A. The role of platelet activating factor in prion and amyloid-beta neurotoxicity. NeuroReport, 15(3), 509-513. https://doi.org/10.1097/01.wnr.0000113065.17279.7b
Microglia kill amyloid-beta(1-42) damaged neurons by a CD14-dependent process
Journal Article
Bate, C., Veerhuis, R., Eikelenboom, P., & Williams, A. E. Microglia kill amyloid-beta(1-42) damaged neurons by a CD14-dependent process. NeuroReport, 15(9), 1427-1430. https://doi.org/10.1097/01.wnr.0000132203.76836.16
Role of glycosylphosphatidylinositols in the activation of phospholipase A(2) and the neurotoxicity of prions
Journal Article
Bate, C., & Williams, A. Role of glycosylphosphatidylinositols in the activation of phospholipase A(2) and the neurotoxicity of prions. Journal of General Virology, 85(85), 3797-3804. https://doi.org/10.1099/vir.0.80366-0
Clustering of sialylated glycosylphosphatidylinositol anchors mediates PrP-induced activation of cytoplasmic phospholipase A(2) and synapse damage
Journal Article
Bate, C., & Williams, A. Clustering of sialylated glycosylphosphatidylinositol anchors mediates PrP-induced activation of cytoplasmic phospholipase A(2) and synapse damage. Prion, 6(4), 350-353. https://doi.org/10.4161/pri.21751
Squalestatin protects neurons and reduces the activation of cytoplasmic phospholipase A(2) by A beta(1-42)
Journal Article
Bate, C., & Williams, A. Squalestatin protects neurons and reduces the activation of cytoplasmic phospholipase A(2) by A beta(1-42). Neuropharmacology, 53(2), 222-231. https://doi.org/10.1016/j.neuropharm.2007.05.003
Statins reduce the neurotoxicity of platelet-activating factor
Journal Article
Bate, C., Rumbold, L., & Williams, A. Statins reduce the neurotoxicity of platelet-activating factor
Glycosylphosphatidylinositols: More than just an anchor?
Journal Article
Bate, C., Nolan, W., & Williams, A. (in press). Glycosylphosphatidylinositols: More than just an anchor?. https://doi.org/10.1080/19420889.2016.1149671
Monoacylated Cellular Prion Proteins Reduce Amyloid-beta-Induced Activation of Cytoplasmic Phospholipase A2 and Synapse Damage
Journal Article
West, E., Osborne, C., Nolan, W., & Bate, C. (in press). Monoacylated Cellular Prion Proteins Reduce Amyloid-beta-Induced Activation of Cytoplasmic Phospholipase A2 and Synapse Damage. Biology, 4(2), 367-82. https://doi.org/10.3390/biology4020367Alzheimer’s disease (AD) is a progressive neurodegenerative disease characterized by the accumulation of amyloid-β (Aβ) and the loss of synapses. Aggregation of the cellular prion protein (PrPC) by Aβ oligomers induced synapse damage in cultured neur... Read More about Monoacylated Cellular Prion Proteins Reduce Amyloid-beta-Induced Activation of Cytoplasmic Phospholipase A2 and Synapse Damage.
a-Synuclein-Induced Synapse Damage in Cultured Neurons Is Mediated by Cholesterol-Sensitive Activation of Cytoplasmic Phospholipase A2
Journal Article
Bate, C., & Williams, A. (in press). a-Synuclein-Induced Synapse Damage in Cultured Neurons Is Mediated by Cholesterol-Sensitive Activation of Cytoplasmic Phospholipase A2. Biomolecules, 5(1), 178-93. https://doi.org/10.3390/biom5010178The accumulation of aggregated forms of the α-synuclein (αSN) is associated with the pathogenesis of Parkinson’s disease (PD) and Dementia with Lewy Bodies. The loss of synapses is an important event in the pathogenesis of these diseases. Here we sho... Read More about a-Synuclein-Induced Synapse Damage in Cultured Neurons Is Mediated by Cholesterol-Sensitive Activation of Cytoplasmic Phospholipase A2.
Enhanced neuronal degradation of amyloid-beta oligomers allows synapse regeneration
Journal Article
Bate, C. Enhanced neuronal degradation of amyloid-beta oligomers allows synapse regeneration. Neural Regeneration Research, 10(5), 700-701. https://doi.org/10.4103/1673-5374.156955
cAMP-Inhibits Cytoplasmic Phospholipase A(2) and Protects Neurons against Amyloid-beta-Induced Synapse Damage
Journal Article
Bate, C., & Williams, A. cAMP-Inhibits Cytoplasmic Phospholipase A(2) and Protects Neurons against Amyloid-beta-Induced Synapse Damage. Biology, 4(3), 591-606. https://doi.org/10.3390/biology4030591
Glimepiride reduces CD14 expression and cytokine secretion from macrophages
Journal Article
Ingham, V., Williams, A., & Bate, C. Glimepiride reduces CD14 expression and cytokine secretion from macrophages. https://doi.org/10.1186/1742-2094-11-115
Platelet-activating factor antagonists enhance intracellular degradation of amyloid-beta(42) in neurons via regulation of cholesterol ester hydrolases
Journal Article
Simmons, C., Ingham, V., Williams, A., & Bate, C. Platelet-activating factor antagonists enhance intracellular degradation of amyloid-beta(42) in neurons via regulation of cholesterol ester hydrolases. https://doi.org/10.1186/alzrt245
The N-Methylated Peptide SEN304 Powerfully Inhibits A beta(1-42) Toxicity by Perturbing Oligomer Formation
Journal Article
Amijee, H., Bate, C., Williams, A., Virdee, J., Jeggo, R., Spanswick, D., …Doig, A. J. The N-Methylated Peptide SEN304 Powerfully Inhibits A beta(1-42) Toxicity by Perturbing Oligomer Formation. Biochemistry, 51(42), 8338-8352. https://doi.org/10.1021/bi300415v
Showing 41 - 55 of 55 results