Characterisation of Plasmodium invasive organelles; an ookinete microneme proteome
Journal Article
Lal, K., Prieto, J. H., Bromley, E., Sanderson, S. J., Yates, J. R. 3., Wastling, J. M., …Sinden, R. E. Characterisation of Plasmodium invasive organelles; an ookinete microneme proteome. Proteomics, 9(5), 1142-51. https://doi.org/10.1002/pmic.200800404
Livestock infectious diseases and zoonoses
Journal Article
Tomley, F. M., & Shirley, M. W. Livestock infectious diseases and zoonoses. Philosophical Transactions of the Royal Society B: Biological Sciences, 364(1530), 2637-42. https://doi.org/10.1098/rstb.2009.0133
New putative virulence factors of Streptococcus suis involved in invasion of porcine brain microvascular endothelial cells
Journal Article
Vanier, G., Fittipaldi, N., Slater, J. D., Dominguez-Punaro, M. D., Rycroft, A. N., Segura, M., …Gottschalk, M. New putative virulence factors of Streptococcus suis involved in invasion of porcine brain microvascular endothelial cells. Microbial Pathogenesis, 46(1), 13-20. https://doi.org/10.1016/j.micpath.2008.10.003
LIPID RAFTS, CELL SIGNALLING, PRION FORMATION AND NEURODEGENERATION IN PRION DISEASES
Journal Article
Williams, A., & Bate, C. LIPID RAFTS, CELL SIGNALLING, PRION FORMATION AND NEURODEGENERATION IN PRION DISEASES. Journal of Neurochemistry, 108, 44-44
Stable transfection of Eimeria tenella: constitutive expression of the YFP-YFP molecule throughout the life cycle.
Journal Article
Yan, W., Liu, X., Shi, T., Hao, L., Tomley, F. M., & Suo, X. Stable transfection of Eimeria tenella: constitutive expression of the YFP-YFP molecule throughout the life cycle. International Journal for Parasitology, 39(1), 109-17. https://doi.org/10.1016/j.ijpara.2008.06.013
MORN1 has a conserved role in asexual and sexual development across the apicomplexa. Eukaryot Cell
Journal Article
Ferguson, D. J. P., Sahoo, N., Pinches, R. A., Bumstead, J. M., Tomley, F. M., & Gubbels, M. J. (in press). MORN1 has a conserved role in asexual and sexual development across the apicomplexa. Eukaryot Cell. https://doi.org/10.1128/EC.00021-08The gene encoding the membrane occupation and recognition nexus protein MORN1 is conserved across the Apicomplexa. In Toxoplasma gondii, MORN1 is associated with the spindle poles, the anterior and posterior rings of the inner membrane complex (IMC).... Read More about MORN1 has a conserved role in asexual and sexual development across the apicomplexa. Eukaryot Cell.
Do prion-induced changes in cholesterol trigger neurodegeneration?
Journal Article
Bate, C., & Williams, A. Do prion-induced changes in cholesterol trigger neurodegeneration?. Future Neurology, 3(4), 367-370. https://doi.org/10.2217/14796708.3.4.367
Sequestration of free cholesterol in cell membranes by prions correlates with cytoplasmic phospholipase A(2) activation
Journal Article
Bate, C., Tayebi, M., & Williams, A. Sequestration of free cholesterol in cell membranes by prions correlates with cytoplasmic phospholipase A(2) activation. BMC Biology, 6, https://doi.org/10.1186/1741-7007-6-8Background: The transmissible spongiform encephalopathies (TSEs), otherwise known as the prion diseases, occur following the conversion of the normal cellular prion protein ( PrPC) to an alternatively folded isoform ( PrPSc). The accumulation of PrPS... Read More about Sequestration of free cholesterol in cell membranes by prions correlates with cytoplasmic phospholipase A(2) activation.
Ginkgolides protect against amyloid-beta(1-42)-mediated synapse damage in vitro
Journal Article
Bate, C., Tayebi, M., & Williams, A. Ginkgolides protect against amyloid-beta(1-42)-mediated synapse damage in vitro. Molecular Neurodegeneration, 3(1), https://doi.org/10.1186/1750-1326-3-1
Cholesterol esterification reduces the neurotoxicity of prions
Journal Article
Bate, C., Tayebi, M., & Williams, A. Cholesterol esterification reduces the neurotoxicity of prions. Neuropharmacology, 54(8), 1247-1253. https://doi.org/10.1016/j.neuropharm.2008.04.002The transmissible spongiform encephalopathies develop following the conversion of a host-encoded protein (PrPC) into abnormally folded, disease-related isoforms (PrPSc). Here we report that three acylcoenzyme A:cholesterol acyltransferase (ACAT) inhi... Read More about Cholesterol esterification reduces the neurotoxicity of prions.
Docosahexaenoic and eicosapentaenoic acids increase prion formation in neuronal cells
Journal Article
Bate, C., Tayebi, M., Diomede, L., Salmona, M., & Williams, A. Docosahexaenoic and eicosapentaenoic acids increase prion formation in neuronal cells. BMC Biology, 6, https://doi.org/10.1186/1741-7007-6-39Background: The transmissible spongiform encephalopathies, otherwise known as prion diseases, occur following the conversion of the cellular prion protein (PrPC) to an alternatively folded, disease-associated isoform (PrPSc). Recent studies suggest t... Read More about Docosahexaenoic and eicosapentaenoic acids increase prion formation in neuronal cells.
Docosahexaenoic and eicosapentaenoic acids increase neuronal death in response to HuPrP82-146 and A beta 1-42
Journal Article
Bate, C., Marshall, V., Colombo, L., Diomede, L., Salmona, M., & Williams, A. Docosahexaenoic and eicosapentaenoic acids increase neuronal death in response to HuPrP82-146 and A beta 1-42. Neuropharmacology, 54(6), 934-943. https://doi.org/10.1016/j.neuropharm.2008.02.003Dietary supplements containing polyunsaturated fatty acids (PUFA) are frequently taken for their perceived health benefits including a possible reduction in cognitive decline in the elderly. Here we report that pre-treatment with docosahexaenoic acid... Read More about Docosahexaenoic and eicosapentaenoic acids increase neuronal death in response to HuPrP82-146 and A beta 1-42.
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