Application of a new PCR-RFLP panel suggests a restricted population structure for Eimeria tenella in UK and Irish chickens
(2016)
Journal Article
Pegg, E., Doyle, K., Clark, E. L., Jatau, I. D., Tomley, F. M., & Blake, D. P. (2016). Application of a new PCR-RFLP panel suggests a restricted population structure for Eimeria tenella in UK and Irish chickens. Veterinary Parasitology, 229, 60-67. https://doi.org/10.1016/j.vetpar.2016.09.018
Toxoplasma gondii detection in cattle: A slaughterhouse survey (2016)
Journal Article
Hosein, S., Limon, G., Dadios, N., Guitian, J., & Blake, D. P. (2016). Toxoplasma gondii detection in cattle: A slaughterhouse survey. Veterinary Parasitology, 228, 126-129. https://doi.org/10.1016/j.vetpar.2016.09.001
Viral proteins expressed in the protozoan parasite Eimeria tenella are detected by the chicken immune system (2016)
Journal Article
Marugan-Hernandez, V., Cockle, C., Macdonald, S. E., Pegg, E., Crouch, C., Blake, D. P., & Tomley, F. M. (2016). Viral proteins expressed in the protozoan parasite Eimeria tenella are detected by the chicken immune system. https://doi.org/10.1186/s13071-016-1756-2
Sialic Acid within the Glycosylphosphatidylinositol Anchor Targets the Cellular Prion Protein to Synapses (2016)
Journal Article
Bate, C., Nolan, W., McHale-Owen, H., & Williams, A. (2016). Sialic Acid within the Glycosylphosphatidylinositol Anchor Targets the Cellular Prion Protein to Synapses. Journal of Biological Chemistry, 291(33), 17093-101. https://doi.org/10.1074/jbc.M116.731117Although the cellular prion protein (PrPC) is concentrated at synapses, the factors that target PrPC to synapses are not understood. Here we demonstrate that exogenous PrPC was rapidly targeted to synapses in recipient neurons derived from Prnp knock... Read More about Sialic Acid within the Glycosylphosphatidylinositol Anchor Targets the Cellular Prion Protein to Synapses.
Analysis of the function of IL-10 in chickens using specific neutralising antibodies and a sensitive capture ELISA (2016)
Journal Article
Wu, Z., Hu, T., Rothwell, L., Vervelde, L., Kaiser, P., Boulton, K., …Hume, D. A. (2016). Analysis of the function of IL-10 in chickens using specific neutralising antibodies and a sensitive capture ELISA. Developmental and Comparative Immunology, 63, 206-212. https://doi.org/10.1016/j.dci.2016.04.016
The Structure of the Transcriptional Repressor KstR in Complex with CoA Thioester Cholesterol Metabolites Sheds Light on the Regulation of Cholesterol Catabolism in Mycobacterium tuberculosis (2016)
Journal Article
Ho, N. A. T., Dawes, S. S., Crowe, A. M., Casabon, I., Gao, C., Kendall, S. L., …Lott, J. S. (2016). The Structure of the Transcriptional Repressor KstR in Complex with CoA Thioester Cholesterol Metabolites Sheds Light on the Regulation of Cholesterol Catabolism in Mycobacterium tuberculosis. Journal of Biological Chemistry, 291(14), 7256-7266. https://doi.org/10.1074/jbc.M115.707760Cholesterol can be a major carbon source for Mycobacterium tuberculosis during infection, both at an early stage in the macrophage phagosome and later within the necrotic granuloma. KstR is a highly conserved TetR family transcriptional repressor tha... Read More about The Structure of the Transcriptional Repressor KstR in Complex with CoA Thioester Cholesterol Metabolites Sheds Light on the Regulation of Cholesterol Catabolism in Mycobacterium tuberculosis.
Does the tail wag the dog? How the structure of a glycosylphosphatidylinositol anchor affects prion formation (2016)
Journal Article
Bate, C., Nolan, W., & Williams, A. (2016). Does the tail wag the dog? How the structure of a glycosylphosphatidylinositol anchor affects prion formation. Prion, 10(2), 127-30. https://doi.org/10.1080/19336896.2016.1148237
Whole genome resequencing of the human parasite Schistosoma mansoni reveals population history and effects of selection (2016)
Journal Article
Crellen, T., Allan, F., David, S., Durrant, C., Huckvale, T., Holroyd, N., …Cotton, J. A. (2016). Whole genome resequencing of the human parasite Schistosoma mansoni reveals population history and effects of selection. https://doi.org/10.1038/srep20954Schistosoma mansoni is a parasitic fluke that infects millions of people in the developing world. This study presents the first application of population genomics to S. mansoni based on high-coverage resequencing data from 10 global isolates and an i... Read More about Whole genome resequencing of the human parasite Schistosoma mansoni reveals population history and effects of selection.
An in vitro model for synaptic loss in neurodegenerative diseases suggests a neuroprotective role for valproic acid via inhibition of cPLA(2) dependent signalling (2016)
Journal Article
Williams, R. S. B., & Bate, C. (2016). An in vitro model for synaptic loss in neurodegenerative diseases suggests a neuroprotective role for valproic acid via inhibition of cPLA(2) dependent signalling. Neuropharmacology, 101, 566-575. https://doi.org/10.1016/j.neuropharm.2015.06.013Many neurodegenerative diseases present the loss of synapses as a common pathological feature. Here we have employed an in vitro model for synaptic loss to investigate the molecular mechanism of a therapeutic treatment, valproic acid (VPA). We show t... Read More about An in vitro model for synaptic loss in neurodegenerative diseases suggests a neuroprotective role for valproic acid via inhibition of cPLA(2) dependent signalling.
Glimepiride protects neurons against amyloid-beta-induced synapse damage (2016)
Journal Article
Osborne, C., West, E., Nolan, W., McHale-Owen, H., Williams, A., & Bate, C. (2016). Glimepiride protects neurons against amyloid-beta-induced synapse damage. Neuropharmacology, 101, 225-236. https://doi.org/10.1016/j.neuropharm.2015.09.030
Sialic Acid on the Glycosylphosphatidylinositol Anchor Regulates PrP-mediated Cell Signaling and Prion Formation (2016)
Journal Article
Bate, C., Nolan, W., McHale-Owen, H., & Williams, A. (2016). Sialic Acid on the Glycosylphosphatidylinositol Anchor Regulates PrP-mediated Cell Signaling and Prion Formation. Journal of Biological Chemistry, 291(33), 17093-17101. https://doi.org/10.1074/jbc.M116.731117The prion diseases occur following the conversion of the cellular prion protein (PrPC) into disease-related isoforms (PrPSc). In this study, the role of the glycosylphosphatidylinositol (GPI) anchor attached to PrPC in prion formation was examined us... Read More about Sialic Acid on the Glycosylphosphatidylinositol Anchor Regulates PrP-mediated Cell Signaling and Prion Formation.