The phospholipase A2 pathway controls a synaptic cholesterol ester cycle and synapse damage (2018)
Journal Article
Osborne, C., West, E., & Bate, C. (2018). The phospholipase A2 pathway controls a synaptic cholesterol ester cycle and synapse damage. Journal of Cell Science, 131(8), https://doi.org/10.1242/jcs.211789

The cellular prion protein (PrPC) acts as a scaffold protein that organises signalling complexes. In synaptosomes, the aggregation of PrPC by amyloid-β (Aβ) oligomers attracts and activates cytoplasmic phospholipase A2 (cPLA2), leading to synapse deg... Read More about The phospholipase A2 pathway controls a synaptic cholesterol ester cycle and synapse damage.

Giardia secretome highlights secreted tenascins as a key component of pathogenesis (2018)
Journal Article
Dubourg, A., Xia, D., Winpenny, J. P., Al Naimi, S., Bouzid, M., Sexton, D. W., …Tyler, K. M. (2018). Giardia secretome highlights secreted tenascins as a key component of pathogenesis. GigaScience, 7(3), 1-13. https://doi.org/10.1093/gigascience/giy003

Cholesterol ester hydrolase inhibitors reduce the production of synaptotoxic amyloid-beta oligomers (2018)
Journal Article
McHale-Owen, H., & Bate, C. (2018). Cholesterol ester hydrolase inhibitors reduce the production of synaptotoxic amyloid-beta oligomers. https://doi.org/10.1016/j.bbadis.2017.12.017

The production of amyloid-β (Aβ) is the key factor driving pathogenesis in Alzheimer's disease (AD). Increasing concentrations of Aβ within the brain cause synapse degeneration and the dementia that is characteristic of AD. Here the factors that affe... Read More about Cholesterol ester hydrolase inhibitors reduce the production of synaptotoxic amyloid-beta oligomers.