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SULF1/SULF2 splice variants differentially regulate pancreatic tumour growth progression.
Journal Article
Gill, R. M. S., Michael, A., Westley, L., Kocher, H. M., Murphy, J. I., & Dhoot, G. K. (in press). SULF1/SULF2 splice variants differentially regulate pancreatic tumour growth progression. Experimental Cell Research, 324, 157-171. https://doi.org/10.1016/j.yexcr.2014.04.001

This study highlights the highly dynamic nature of SULF1/SULF2 splice variants in different human pancreatic cancers that regulate the activities of multiple cell signalling pathways in development and disease. Most pancreatic tumours expressed varia... Read More about SULF1/SULF2 splice variants differentially regulate pancreatic tumour growth progression..

Sulf1 and Sulf2 expression in the nervous system and its role in limiting neurite outgrowth in vitro
Journal Article
Joy, M. T., Vrbova, G., Dhoot, G. K., & Anderson, P. N. (in press). Sulf1 and Sulf2 expression in the nervous system and its role in limiting neurite outgrowth in vitro. Experimental Neurology, 263, 150-160. https://doi.org/10.1016/j.expneurol.2014.10.011

Sulf1 and Sulf2 are endosulfatases that cleave 6-O-sulphate groups from Heparan Sulphate Proteoglycans (HSPGs). Sulfation levels of HSPGs are critical for their role in modulating the activity of various growth factor receptors. Sulf1 and Sulf2 mRNAs... Read More about Sulf1 and Sulf2 expression in the nervous system and its role in limiting neurite outgrowth in vitro.