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Physiological reactivity to spontaneously occurring seizure activity in dogs with epilepsy and their carers (2017)
Journal Article
Packer, R. M. A., Volk, H. A., & Fowkes, R. C. (2017). Physiological reactivity to spontaneously occurring seizure activity in dogs with epilepsy and their carers. Physiology and Behavior, 177, 27-33. https://doi.org/10.1016/j.physbeh.2017.04.008

There is a complex bidirectional relationship between stress and epilepsy. Stressful stimuli and subsequent cortisol release act as a trigger for seizure activity in some individuals with epilepsy, and seizure activity itself may act as a stressor to... Read More about Physiological reactivity to spontaneously occurring seizure activity in dogs with epilepsy and their carers.

Breed, Coat Color, and Hair Length as Risk Factors for Hyperthyroidism in Cats (2017)
Journal Article
Crossley, V. J., Debnath, A., Chang, Y. M., Fowkes, R. C., Elliott, J., & Syme, H. M. (2017). Breed, Coat Color, and Hair Length as Risk Factors for Hyperthyroidism in Cats. Journal of Veterinary Internal Medicine, 31(4), 1028-1034. https://doi.org/10.1111/jvim.14737

Hyperthyroidism is very common in older cats, but the etiopathogenesis is poorly understood. Decreased risk of hyperthyroidism has been reported in certain colorpoint breeds, and this observation previously has been hypothesized to result from relati... Read More about Breed, Coat Color, and Hair Length as Risk Factors for Hyperthyroidism in Cats.

Natriuretic peptide activation of extracellular regulated kinase 1/2 (ERK1/2) pathway by particulate guanylyl cyclases in GH3 somatolactotropes (2017)
Journal Article
Jonas, K. C., Melrose, T., Thompson, I. R., Baxter, G. F., Lipscomb, V. J., Niessen, S. J. M., …Fowkes, R. C. (2017). Natriuretic peptide activation of extracellular regulated kinase 1/2 (ERK1/2) pathway by particulate guanylyl cyclases in GH3 somatolactotropes. Cell and Tissue Research, 369(3), 567-578. https://doi.org/10.1007/s00441-017-2624-x

The natriuretic peptides, Atrial-, B-type and C-type natriuretric peptides (ANP, BNP, CNP), are regulators of many endocrine tissues and exert their effects predominantly through the activation of their specific guanylyl cyclase receptors (GC-A and G... Read More about Natriuretic peptide activation of extracellular regulated kinase 1/2 (ERK1/2) pathway by particulate guanylyl cyclases in GH3 somatolactotropes.

Feline hypersomatotropism and acromegaly tumorigenesis: a potential role for the AIP gene (2017)
Journal Article
Scudder, C. J., Niessen, S. J. M., Catchpole, B., Fowkes, R. C., Church, D. B., & Forcada, Y. (2017). Feline hypersomatotropism and acromegaly tumorigenesis: a potential role for the AIP gene. Domestic Animal Endocrinology, 59, 134-139. https://doi.org/10.1016/j.domaniend.2016.11.005

Acromegaly in humans is usually sporadic, however up to 20% of familial isolated pituitary adenomas are caused by germline sequence variants of the aryl-hydrocarbon-receptor interacting protein (AIP) gene. Feline acromegaly has similarities to human... Read More about Feline hypersomatotropism and acromegaly tumorigenesis: a potential role for the AIP gene.

Homologous and heterologous desensitization of guanylyl cyclase-B signaling in GH3 somatolactotropes (2014)
Journal Article
Thompson, I. R., Mirczuk, S. M., Smith, L., Lessey, A. J., Simbi, B., Sunters, A., …Fowkes, R. C. (2014). Homologous and heterologous desensitization of guanylyl cyclase-B signaling in GH3 somatolactotropes. Cell and Tissue Research, 355(2), 425-36. https://doi.org/10.1007/s00441-013-1763-y

The guanylyl cyclases, GC-A and GC-B, are selective receptors for atrial and C-type natriuretic peptides (ANP and CNP, respectively). In the anterior pituitary, CNP and GC-B are major regulators of cGMP production in gonadotropes and yet mouse models... Read More about Homologous and heterologous desensitization of guanylyl cyclase-B signaling in GH3 somatolactotropes.

Pulsatile Hormonal Signaling to Extracellular Signal-Regulated Kinase: Exploring System Sensitivity to Gonadotropin-Releasing Hormone Pulse Frequency and Width (2014)
Journal Article
Perrett, R. M., Voliotis, M., Armstrong, S. P., Fowkes, R. C., Pope, G. R., Tsaneva-Atanasova, K., & McArdle, C. A. (2014). Pulsatile Hormonal Signaling to Extracellular Signal-Regulated Kinase: Exploring System Sensitivity to Gonadotropin-Releasing Hormone Pulse Frequency and Width. Journal of Biological Chemistry, 289(11), 7873-7883. https://doi.org/10.1074/jbc.M113.532473

Gonadotropin-releasing hormone (GnRH) is secreted in brief pulses that stimulate synthesis and secretion of pituitary gonadotropin hormones and thereby mediate control of reproduction. It acts via G-protein-coupled receptors to stimulate effectors, i... Read More about Pulsatile Hormonal Signaling to Extracellular Signal-Regulated Kinase: Exploring System Sensitivity to Gonadotropin-Releasing Hormone Pulse Frequency and Width.