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Outputs (104)

Sost haploinsufficiency provokes peracute lethal cardiac tamponade without rescuing the osteopenia in a mouse model of excess glucocorticoids (2019)
Journal Article
Javaheri, B., Herbert, E., Hopkinson, M., Al-Jazzar, A., & Pitsillides, A. A. (2019). Sost haploinsufficiency provokes peracute lethal cardiac tamponade without rescuing the osteopenia in a mouse model of excess glucocorticoids. American Journal of Pathology, 189(4), 753-761. https://doi.org/10.1016/j.ajpath.2018.12.007

Glucocorticoid-induced secondary osteoporosis is the most predictable side-effect of this anti-inflammatory. One of the main mechanisms by which glucocorticoids achieve such deleterious outcome in bone is by antagonizing Wnt/β-catenin signalling. Scl... Read More about Sost haploinsufficiency provokes peracute lethal cardiac tamponade without rescuing the osteopenia in a mouse model of excess glucocorticoids.

Reverse-engineering the locomotion of a stem amniote (2019)
Journal Article
Nyakatura, J. A., Melo, K., Horvat, T., Karakasiliotis, K., Allen, V. R., Andikfar, A., …Ijspeert, A. J. (2019). Reverse-engineering the locomotion of a stem amniote. Nature, 565, 351-355. https://doi.org/10.1038/s41586-018-0851-2

Reconstructing the locomotion of extinct vertebrates offers insights into their palaeobiology and helps to conceptualize major transitions in vertebrate evolution. However, estimating the locomotor behaviour of a fossil species remains a challenge be... Read More about Reverse-engineering the locomotion of a stem amniote.

Structural characteristics and predicted functional capacities of epaxial muscles in chondrodystrophic and non-chondrodystrophic dogs with and without suspected intervertebral disc herniation- a preliminary study (2019)
Journal Article
Boström, A., Channon, S. B., Jokinen, T. S., Junnila, J., Hielm-Bjorkman, A. K., & Laitinen-Vapaavuori, O. (2019). Structural characteristics and predicted functional capacities of epaxial muscles in chondrodystrophic and non-chondrodystrophic dogs with and without suspected intervertebral disc herniation- a preliminary study. Research in Veterinary Science, 123, 204-215. https://doi.org/10.1016/j.rvsc.2019.01.008

Epaxial muscle atrophy is related to spinal diseases in dogs. However, the influence of intervertebral disc herniation (IVDH) on the functional capacity of epaxial muscles has not been investigated. We aimed to estimate force and power-generating cap... Read More about Structural characteristics and predicted functional capacities of epaxial muscles in chondrodystrophic and non-chondrodystrophic dogs with and without suspected intervertebral disc herniation- a preliminary study.

The locomotor kinematics and ground reaction forces of walking giraffes. (2019)
Journal Article
Basu, C. K., Wilson, A. M., & Hutchinson, J. R. (2019). The locomotor kinematics and ground reaction forces of walking giraffes. Journal of Experimental Biology, 222(22), https://doi.org/10.1242/jeb.159277

Giraffes (Giraffa camelopardalis Linnaeus 1758) possess specialised anatomy. Their disproportionately elongate limbs and neck confer recognised feeding advantages, but little is known about how their morphology affects locomotor function. In this stu... Read More about The locomotor kinematics and ground reaction forces of walking giraffes..

Pituitary pathology and gene expression in acromegalic cats (2019)
Journal Article
Scudder, C. J., Mirczuk, S. M., Richardson, K. M., Crossley, V. J., Regan, J. T. C., Gostelow, R., …Niessen, S. J. M. (2019). Pituitary pathology and gene expression in acromegalic cats. Journal of the Endocrine Society, 3(1), 181-200. https://doi.org/10.1210/js.2018-00226

The prevalence of growth hormone secreting pituitary tumours in domestic cats (Felis catus) is ten times greater than in humans. The predominant inhibitory receptors of growth hormone-secreting pituitary tumours are somatostatin receptors (SSTRs) and... Read More about Pituitary pathology and gene expression in acromegalic cats.

Differential susceptibility to tetracycline, oxytetracycline and doxycycline of the calf pathogens Mannheimia haemolytica and Pasteurella multocida in three growth media (2019)
Journal Article
Mead, A., Lees, P., Mitchell, J., Rycroft, A. N., Standing, J. F., Toutain, P. L., & Pelligand, L. (2019). Differential susceptibility to tetracycline, oxytetracycline and doxycycline of the calf pathogens Mannheimia haemolytica and Pasteurella multocida in three growth media. Journal of Veterinary Pharmacology and Therapeutics, 42(1), 52-59. https://doi.org/10.1111/jvp.12719

For clinical isolates of bovine Mannheimia haemolytica and Pasteurella multocida, this study reports minimum inhibitory concentration (MIC) differences for tetracycline, oxytetracycline and doxycycline between cation‐adjusted Mueller‐Hinton broth (CA... Read More about Differential susceptibility to tetracycline, oxytetracycline and doxycycline of the calf pathogens Mannheimia haemolytica and Pasteurella multocida in three growth media.

Magnesium induces preconditioning of the neonatal brain via profound mitochondrial protection (2019)
Journal Article
Koring, G., Leverin, A. L., Nair, S., Schwendimann, L., Ek, J., Carlsson, Y., …Hagberg, H. (2019). Magnesium induces preconditioning of the neonatal brain via profound mitochondrial protection. https://doi.org/10.1177/0271678X17746132

Magnesium sulphate (MgSO4) given to women in preterm labor reduces cerebral palsy in their offspring but the mechanism behind this protection is unclear, limiting its effective, safe clinical implementation. Previous studies suggest that MgSO4 is not... Read More about Magnesium induces preconditioning of the neonatal brain via profound mitochondrial protection.