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Outputs (104)

Evolution of gene regulation in ruminants differs between evolutionary breakpoint regions and homologous synteny blocks (2019)
Journal Article
Farre Belmonte, M., Kim, J., Proskuryakova, A. A., Zhang, Y., Kulemzina, A. I., Li, Q., …Larkin, D. M. (2019). Evolution of gene regulation in ruminants differs between evolutionary breakpoint regions and homologous synteny blocks. Genome Research, 29, 576-589. https://doi.org/10.1101/gr.239863.118

The role of chromosome rearrangements in driving evolution has been a long-standing question of evolutionary biology. Here we focused on ruminants as a model to assess how rearrangements may have contributed to the evolution of gene regulation. Using... Read More about Evolution of gene regulation in ruminants differs between evolutionary breakpoint regions and homologous synteny blocks.

The running kinematics of free-roaming giraffes, measured using a low cost unmanned aerial vehicle (UAV) (2019)
Journal Article
Basu, C. K., Deacon, F., Hutchinson, J. R., & Wilson, A. M. (2019). The running kinematics of free-roaming giraffes, measured using a low cost unmanned aerial vehicle (UAV). PeerJ, 7, e6312. https://doi.org/10.7717/peerj.6312

The study of animal locomotion can be logistically challenging, especially in the case of large or unhandleable animals in uncontrolled environments. Here we demonstrate the utility of a low cost unmanned aerial vehicle (UAV) in measuring two-dimensi... Read More about The running kinematics of free-roaming giraffes, measured using a low cost unmanned aerial vehicle (UAV).

Parsimonious test of dynamic interaction (2019)
Journal Article
Chisholm, S., Stein, A. B., Jordan, N. R., Hubel, T. Y., Shawe-Taylor, J., Fearn, T., …Hailes, S. (2019). Parsimonious test of dynamic interaction. Ecology and Evolution, https://doi.org/10.1002/ece3.4805

In recent years, there have been significant advances in the technology used to collect data on the movement and activity patterns of humans and animals. GPS units, which form the primary source of location data, have become cheaper, more accurate, l... Read More about Parsimonious test of dynamic interaction.

Unique skull network complexity of Tyrannosaurus rex among land vertebrates (2019)
Journal Article
Werneburg, I., Esteve-Altava, B., Bruno, J., Torres Ladeira, M., & Diogo, R. (2019). Unique skull network complexity of Tyrannosaurus rex among land vertebrates. https://doi.org/10.1038/s41598-018-37976-8

Like other diapsids, Tyrannosaurus rex has two openings in the temporal skull region. In addition, like in other dinosaurs, its snout and lower jaw show large cranial fenestrae. In T. rex, they are thought to decrease skull weight, because, unlike mo... Read More about Unique skull network complexity of Tyrannosaurus rex among land vertebrates.

A Near Chromosome Assembly of the Dromedary Camel Genome (2019)
Journal Article
Ruvinskiy, D., Larkin, D. M., & Farré, M. (2019). A Near Chromosome Assembly of the Dromedary Camel Genome. Frontiers in Genetics, 10(32), https://doi.org/10.3389/fgene.2019.00032

The dromedary camel is an economically and socially important species of livestock in many parts of the world, being used for transport and the production of milk and meat. Much like cattle and horses, the camel may be found in industrial farming con... Read More about A Near Chromosome Assembly of the Dromedary Camel Genome.

Cmah-dystrophin deficient mdx mice display an accelerated cardiac phenotype that is improved following peptide-PMO exon skipping treatment (2019)
Journal Article
Betts, C. A., McClorey, G., Healicon, R., Hammond, S. M., Manzano, R., Muses, S., …Wood, M. J. (2019). Cmah-dystrophin deficient mdx mice display an accelerated cardiac phenotype that is improved following peptide-PMO exon skipping treatment. Human Molecular Genetics, 28(3), 396-406. https://doi.org/10.1093/hmg/ddy346

Duchenne muscular dystrophy (DMD) is caused by loss of dystrophin protein, leading to progressive muscle weakness and premature death due to respiratory and/or cardiac complications. Cardiac involvement is characterized by progressive dilated cardiom... Read More about Cmah-dystrophin deficient mdx mice display an accelerated cardiac phenotype that is improved following peptide-PMO exon skipping treatment.

Identification of qPCR reference genes suitable for normalizing gene expression in the mdx mouse model of Duchenne muscular dystrophy (2019)
Journal Article
Hildyard, J. C. W., Finch, A. M., & Wells, D. J. (2019). Identification of qPCR reference genes suitable for normalizing gene expression in the mdx mouse model of Duchenne muscular dystrophy. PLoS ONE, 14(1), e0211384. https://doi.org/10.1371/journal.pone.0211384

The mdx mouse is the most widely-used animal model of the human disease Duchenne muscular dystrophy, and quantitative PCR analysis of gene expression in the muscles of this animal plays a key role in the study of pathogenesis and disease progression... Read More about Identification of qPCR reference genes suitable for normalizing gene expression in the mdx mouse model of Duchenne muscular dystrophy.

LIPID MEDIATORS IN IMMUNE REGULATION AND RESOLUTION (2019)
Journal Article
Gilroy, D. W., & Bishop-Bailey, D. (2019). LIPID MEDIATORS IN IMMUNE REGULATION AND RESOLUTION. British Journal of Pharmacology, 176(8), https://doi.org/10.1111/bph.14587

We are all too familiar with the events that follow a bee sting – heat, redness, swelling and pain. These are Celsus’ four cardinal signs of inflammation that are driven by very well defined signals and hormones; in fact targeting the factors that dr... Read More about LIPID MEDIATORS IN IMMUNE REGULATION AND RESOLUTION.

Comparison of in vitro static and dynamic assays to evaluate the efficacy of an antimicrobial drug combination against Staphylococcus aureus (2019)
Journal Article
Broussou, D. C., Toutain, P., Woehrlé, F., El Garch, F., Bousquet-Mélou, A., & Ferran, A. A. (2019). Comparison of in vitro static and dynamic assays to evaluate the efficacy of an antimicrobial drug combination against Staphylococcus aureus. PLoS ONE, 14(1), e0211214. https://doi.org/10.1371/journal.pone.0211214

An easily implementable strategy to reduce treatment failures in severe bacterial infections is to combine already available antibiotics. However, most in vitro combination assays are performed by exposing standard bacterial inocula to constant conce... Read More about Comparison of in vitro static and dynamic assays to evaluate the efficacy of an antimicrobial drug combination against Staphylococcus aureus.