Outputs (2401)

Dmp1 Promoter-Driven Diphtheria Toxin Receptor Transgene Expression Directs Unforeseen Effects in Multiple Tissues (2017)
Journal Article
Al-Jazzar, A., Javaheri, B., Prideaux, M., Boyde, A., Scudamore, C. L., Cherifi, C., …Pitsillides, A. A. (2017). Dmp1 Promoter-Driven Diphtheria Toxin Receptor Transgene Expression Directs Unforeseen Effects in Multiple Tissues. International Journal of Molecular Sciences, 18(1), https://doi.org/10.3390/ijms18010029

Mice harbouring a dentin matrix protein 1 (Dmp1) promoter-driven human diphtheria toxin (DT) receptor (HDTR) transgene (Tg) have recently been used to attain targeted ablation of osteocytes by diphtheria toxin (DT) treatment in order to define osteoc... Read More about Dmp1 Promoter-Driven Diphtheria Toxin Receptor Transgene Expression Directs Unforeseen Effects in Multiple Tissues.

A highly prevalent equine glycogen storage disease is explained by constitutive activation of a mutant glycogen synthase (2017)
Journal Article
Maile, C. A., Hingst, J. R., Mahalingan, K. K., O'Reilly, A. O., Cleasby, M. E., Mickelson, J. R., …Piercy, R. J. (2017). A highly prevalent equine glycogen storage disease is explained by constitutive activation of a mutant glycogen synthase. https://doi.org/10.1016/j.bbagen.2016.08.021

Immune senescence: significance of the stromal microenvironment (2017)
Journal Article
Masters, A. R., Haynes, L., Su, D., & Palmer, D. B. (2017). Immune senescence: significance of the stromal microenvironment. Clinical and Experimental Immunology, 187, 6-15. https://doi.org/10.1111/cei.12851

Sclerostin does not play a major role in the pathogenesis of skeletal complications in type 2 diabetes mellitus (2017)
Journal Article
Pereira, M., Gohin, S., Lund, N., Hvid, A., Smitham, P. J., Oddy, M. J., …Chenu, C. (2017). Sclerostin does not play a major role in the pathogenesis of skeletal complications in type 2 diabetes mellitus. Osteoporosis International, 28(1), 309-320. https://doi.org/10.1007/s00198-016-3718-0

Tumour-derived alkaline phosphatase regulates tumour growth, epithelial plasticity and disease-free survival in metastatic prostate cancer (2017)
Journal Article
Rao, S. R., Snaith, A. E., Marino, D., Cheng, X., Lwin, S. T., Orriss, I. R., …Edwards, C. M. (2017). Tumour-derived alkaline phosphatase regulates tumour growth, epithelial plasticity and disease-free survival in metastatic prostate cancer. British Journal of Cancer, 116, 227-236. https://doi.org/10.1038/bjc.2016.402

Feline hypersomatotropism and acromegaly tumorigenesis: a potential role for the AIP gene (2017)
Journal Article
Scudder, C. J., Niessen, S. J. M., Catchpole, B., Fowkes, R. C., Church, D. B., & Forcada, Y. (2017). Feline hypersomatotropism and acromegaly tumorigenesis: a potential role for the AIP gene. Domestic Animal Endocrinology, 59, 134-139. https://doi.org/10.1016/j.domaniend.2016.11.005

Acromegaly in humans is usually sporadic, however up to 20% of familial isolated pituitary adenomas are caused by germline sequence variants of the aryl-hydrocarbon-receptor interacting protein (AIP) gene. Feline acromegaly has similarities to human... Read More about Feline hypersomatotropism and acromegaly tumorigenesis: a potential role for the AIP gene.

A zebrafish model for functional screening of flow-responsive genes (2017)
Journal Article
Serbanovic-Canic, J., De Luca, A., Warboys, C. M., Hsiao, S., Feng, S., Luong, L., …Evans, P. C. (2017). A zebrafish model for functional screening of flow-responsive genes. Arteriosclerosis, Thrombosis, and Vascular Biology, 37, 130-143. https://doi.org/10.1161/ATVBAHA.116.308502

Standard PK/PD concepts can be applied to determine a dosage regimen for a macrolide: the case of tulathromycin in the calf (2017)
Journal Article
Toutain, P. L., Potter, T. J., Pelligand, L., Lacroix, M., Illambas, J., & Lees, P. (2017). Standard PK/PD concepts can be applied to determine a dosage regimen for a macrolide: the case of tulathromycin in the calf. Journal of Veterinary Pharmacology and Therapeutics, 40(1), 16-27. https://doi.org/10.1111/jvp.12333

The pharmacokinetic (PK) profile of tulathromycin, administered to calves subcutaneously at the dosage of 2.5 mg/kg, was established in serum, inflamed (exudate), and noninflamed (transudate) fluids in a tissue cage model. The PK profile of tulathrom... Read More about Standard PK/PD concepts can be applied to determine a dosage regimen for a macrolide: the case of tulathromycin in the calf.

Overexpression of TIMP-3 in chondrocytes produces transient reduction in growth plate length but permanently reduces adult bone quality and quantity (2016)
Journal Article
Poulet, B., Liu, K., Plumb, D., Vo, P., Shah, M., Staines, K. A., …Bou-Gharios, G. (2016). Overexpression of TIMP-3 in chondrocytes produces transient reduction in growth plate length but permanently reduces adult bone quality and quantity. PLoS ONE, 11(12), e0167971. https://doi.org/10.1371/journal.pone.0167971

Characterisation of the Immunophenotype of Dogs with Primary Immune-Mediated Haemolytic Anaemia (2016)
Journal Article
Swann, J. W., Woods, K., Wu, Y., Glanemann, B., & Garden, O. A. (2016). Characterisation of the Immunophenotype of Dogs with Primary Immune-Mediated Haemolytic Anaemia. PLoS ONE, 11(12), e0168296. https://doi.org/10.1371/journal.pone.0168296