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Osteomimetic matrix components alter cell migration and drug response in a 3D tumour-engineered osteosarcoma model
Journal Article
Pavlou, M., Shah, M., Gikas, P., Briggs, T., Roberts, S. J., & Cheema, U. (in press). Osteomimetic matrix components alter cell migration and drug response in a 3D tumour-engineered osteosarcoma model. Acta Biomaterialia, 96, 247-257. https://doi.org/10.1016/j.actbio.2019.07.011

vulnerable to recurring disease and pulmonary metastases. Developing 3D in vitro disease models to serve as a test bed for personalised treatment is a promising approach to address this issue. This study describes the generation of 3D osteosarcoma mo... Read More about Osteomimetic matrix components alter cell migration and drug response in a 3D tumour-engineered osteosarcoma model.

Established PABPN1 intranuclear inclusions in OPMD muscle can be efficiently reversed by AAV-mediated knock-down and replacement of mutant expanded PABPN1
Journal Article
Malerba, A., Klein, P., Lu-Nguyen, N., Cappellari, O., Strings-Ufombah, V., Harbaran, S., …Dickson, G. (in press). Established PABPN1 intranuclear inclusions in OPMD muscle can be efficiently reversed by AAV-mediated knock-down and replacement of mutant expanded PABPN1. Human Molecular Genetics, 28(19), 3301-3308. https://doi.org/10.1093/hmg/ddz167

An instrumented centrifuge for studying mouse locomotion and behaviour under hypergravity
Journal Article
Smith, B. J. H., & Usherwood, J. R. (in press). An instrumented centrifuge for studying mouse locomotion and behaviour under hypergravity. Biology Open, 8, https://doi.org/10.1242/bio.043018

Gravity may influence multiple aspects of legged locomotion, from the periods of limbs moving as pendulums to the muscle forces required to support the body. We present a system for exposing mice to hypergravity using a centrifuge and studying their... Read More about An instrumented centrifuge for studying mouse locomotion and behaviour under hypergravity.

An extension to the collisional model of the energetic cost of support qualitatively explains trotting and the trot–canter transition
Journal Article
Usherwood, J. R. (in press). An extension to the collisional model of the energetic cost of support qualitatively explains trotting and the trot–canter transition. https://doi.org/10.1002/jez.2268

The majority of terrestrial mammals adopt distinct, discrete gaits across their speed range. Though there is evidence that walk, trot and gallop may be selected at speeds consistent with minimizing metabolic cost (Hoyt and Taylor, 1981, Nature, 291,... Read More about An extension to the collisional model of the energetic cost of support qualitatively explains trotting and the trot–canter transition.

Possible causes of divergent population trends in sympatric African herbivores
Journal Article
Bennitt, E., Hubel, T. Y., Bartlam-Brooks, H. L. A., & Wilson, A. M. (in press). Possible causes of divergent population trends in sympatric African herbivores. PLoS ONE, 14(3), e0213720. https://doi.org/10.1371/journal.pone.0213720

Sympatric herbivores experience similar environmental conditions but can vary in their population trends. Identifying factors causing these differences could assist conservation efforts aimed at maintaining fully functional ecosystems. From 1996–2013... Read More about Possible causes of divergent population trends in sympatric African herbivores.