Activin signals via SMAD2/3 between germ and somatic cells in the human fetal ovary and regulates kit ligand expression
(2008)
Journal Article
Coutts, S. M., Childs, A. J., Fulton, N., Collins, C., Bayne, R. A. L., McNeilly, A. S., & Anderson, R. A. (2008). Activin signals via SMAD2/3 between germ and somatic cells in the human fetal ovary and regulates kit ligand expression. Developmental Biology, 314(1), 189-199. https://doi.org/10.1016/j.ydbio.2007.11.026
Ovarian germ cell survival is dependent upon the formation of primordial follicles, which occurs during fetal life in the human. Activin contributes to germ cell proliferation and survival at this time. SMADs2 and 3 are central elements in the activi... Read More about Activin signals via SMAD2/3 between germ and somatic cells in the human fetal ovary and regulates kit ligand expression.