Outputs (48)

Ontogenetic scaling patterns and functional anatomy of the pelvic limb musculature in emus (Dromaius novaehollandiae) (2014)
Journal Article
Lamas, L., Main, R. P., & Hutchinson, J. R. (2014). Ontogenetic scaling patterns and functional anatomy of the pelvic limb musculature in emus (Dromaius novaehollandiae). https://doi.org/10.7717/peerj.716

Emus (Dromaius novaehollandiae) are exclusively terrestrial, bipedal and cursorial ratites with some similar biomechanical characteristics to humans. Their growth rates are impressive, as their body mass increases eighty-fold from hatching to adultho... Read More about Ontogenetic scaling patterns and functional anatomy of the pelvic limb musculature in emus (Dromaius novaehollandiae).

Comparative genomics reveals insights into avian genome evolution and adaptation (2014)
Journal Article
Zhang, G., Li, C., Li, Q., Li, B., Larkin, D. M., & Lee, C. (2014). Comparative genomics reveals insights into avian genome evolution and adaptation. Science, 346(6215), 1311-1320. https://doi.org/10.1126/science.1251385

Birds are the most species-rich class of tetrapod vertebrates and have wide relevance across many research fields. We explored bird macroevolution using full genomes from 48 avian species representing all major extant clades. The avian genome is prin... Read More about Comparative genomics reveals insights into avian genome evolution and adaptation.

Reconstruction of gross avian genome structure, organization and evolution suggests that the chicken lineage most closely resembles the dinosaur avian ancestor (2014)
Journal Article
Romanov, M. N., Farré, M., Lithgow, P. E., Fowler, K. E., Skinner, B. M., O'Connor, R., …Griffin, D. K. (2014). Reconstruction of gross avian genome structure, organization and evolution suggests that the chicken lineage most closely resembles the dinosaur avian ancestor. BMC Genomics, 15, https://doi.org/10.1186/1471-2164-15-1060

TSPO interacts with VDAC1 and triggers a ROS-mediated inhibition of mitochondrial quality control (2014)
Journal Article
Gatliff, J., East, D. A., Crosby, J., Abeti, R., Harvey, R., Craigen, W., …Campanella, M. (2014). TSPO interacts with VDAC1 and triggers a ROS-mediated inhibition of mitochondrial quality control. Autophagy, 10(12), 2279-96. https://doi.org/10.4161/15548627.2014.991665

The 18-kDa TSPO (translocator protein) localizes on the outer mitochondrial membrane (OMM) and participates in cholesterol transport. Here, we report that TSPO inhibits mitochondrial autophagy downstream of the PINK1-PARK2 pathway, preventing essenti... Read More about TSPO interacts with VDAC1 and triggers a ROS-mediated inhibition of mitochondrial quality control.

Iodine vapor staining for atomic number contrast in backscattered electron and X-ray imaging (2014)
Journal Article
Boyde, A., McCorkell, F. A., Taylor, G. K., Bomphrey, R. J., & Doube, M. (2014). Iodine vapor staining for atomic number contrast in backscattered electron and X-ray imaging. Microscopy Research and Technique, 77(12), 1044-1051. https://doi.org/10.1002/jemt.22435

Iodine imparts strong contrast to objects imaged with electrons and X‐rays due to its high atomic number (53), and is widely used in liquid form as a microscopic stain and clinical contrast agent. We have developed a simple technique which exploits e... Read More about Iodine vapor staining for atomic number contrast in backscattered electron and X-ray imaging.

PMI: A Delta Psi(m) Independent Pharmacological Regulator of Mitophagy (2014)
Journal Article
East, D. A., Fagiani, F., Crosby, J., Georgakopoulos, N. D., Bertrand, H., Schaap, M., …Campanella, M. (2014). PMI: A Delta Psi(m) Independent Pharmacological Regulator of Mitophagy. https://doi.org/10.1016/j.chembiol.2014.09.019

Mitophagy is central to mitochondrial and cellular homeostasis and operates via the PINK1/Parkin pathway targeting mitochondria devoid of membrane potential (ΔΨm) to autophagosomes. Although mitophagy is recognized as a fundamental cellular process,... Read More about PMI: A Delta Psi(m) Independent Pharmacological Regulator of Mitophagy.

Mitigating the Goldilocks effect: the effects of different substrate models on track formation potential (2014)
Journal Article
Falkingham, P. L., Hage, J., & Baeker, M. (2014). Mitigating the Goldilocks effect: the effects of different substrate models on track formation potential. Royal Society Open Science, 1(3), 140225. https://doi.org/10.1098/rsos.140225

In ichnology, the Goldilocks effect describes a scenario in which a substrate must be ‘just right’ in order for tracks to form—too soft, the animal will be unable to traverse the area, and too firm, the substrate will not deform. Any given substrate... Read More about Mitigating the Goldilocks effect: the effects of different substrate models on track formation potential.

Don't break a leg: Running birds from quail to ostrich prioritise leg safety and economy in uneven terrain (2014)
Journal Article
Birn-Jeffery, A. V., Hubicki, C. M., Blum, Y., Renjewski, D., Hurst, J. W., & Daley, M. A. (2014). Don't break a leg: Running birds from quail to ostrich prioritise leg safety and economy in uneven terrain. Journal of Experimental Biology, 217(Pt21), 3786-96. https://doi.org/10.1242/jeb.102640

Cursorial ground birds are paragons of bipedal running that span a 500-fold mass range from quail to ostrich. Here we investigate the task-level control priorities of cursorial birds by analysing how they negotiate single-step obstacles that create a... Read More about Don't break a leg: Running birds from quail to ostrich prioritise leg safety and economy in uneven terrain.

Expression of Protease-Activated Receptor 1 and 2 and Anti-Tubulogenic Activity of Protease-Activated Receptor 1 in Human Endothelial Colony-Forming Cells (2014)
Journal Article
Fortunato, T. M., Vara, D. S., Wheeler-Jones, C. P. D., & Pula, G. (2014). Expression of Protease-Activated Receptor 1 and 2 and Anti-Tubulogenic Activity of Protease-Activated Receptor 1 in Human Endothelial Colony-Forming Cells. PLoS ONE, 9(10), https://doi.org/10.1371/journal.pone.0109375

Endothelial colony-forming cells (ECFCs) are obtained from the culture of human peripheral blood mononuclear cell (hPBMNC) fractions and are characterised by high proliferative and pro-vasculogenic potential, which makes them of great interest for ce... Read More about Expression of Protease-Activated Receptor 1 and 2 and Anti-Tubulogenic Activity of Protease-Activated Receptor 1 in Human Endothelial Colony-Forming Cells.

Mineralisation of collagen rich soft tissues and osteocyte lacunae in Enpp1-/- mice (2014)
Journal Article
Hajjawi, M. O. R., MacRae, V. E., Huesa, C., Boyde, A., Millan, J. L., Arnett, T. R., & Orriss, I. R. (2014). Mineralisation of collagen rich soft tissues and osteocyte lacunae in Enpp1-/- mice. BONE, 69, 139-147. https://doi.org/10.1016/j.bone.2014.09.016

Ecto-nucleotide pyrophosphatase/phosphodiesterases (NPPs) hydrolyse nucleotide triphosphates to the corresponding nucleotide monophosphates and the mineralisation inhibitor, pyrophosphate (PPi). This study examined the role of NPP1 in osteocytes, ost... Read More about Mineralisation of collagen rich soft tissues and osteocyte lacunae in Enpp1-/- mice.