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Outputs (12)

A possible solution to model nonlinearity in elimination and distributional clearances with a2-adrenergic receptor agonists: Example of the intravenous detomidine and methadone combination in sedated horses (2019)
Journal Article
Gozalo-Marcilla, M., Moreira Da Silva, R., Pacca Loureiro Luna, S., Rodrigues De Oliveira, A., Werneck Fonseca, M., Peporine Lopes, N., …Pelligand, L. (2019). A possible solution to model nonlinearity in elimination and distributional clearances with a2-adrenergic receptor agonists: Example of the intravenous detomidine and methadone combination in sedated horses. Journal of Veterinary Pharmacology and Therapeutics, https://doi.org/10.1111/jvp.12815

Pregabalin for the treatment of syringomyelia-associated neuropathic pain in dogs: A randomised, placebo-controlled, double-masked clinical trial (2019)
Journal Article
Sanchis-Mora, S., Chang, Y. M., Abeyesinghe, S. M., Fisher, A., Upton, N., Volk, H. A., & Pelligand, L. (2019). Pregabalin for the treatment of syringomyelia-associated neuropathic pain in dogs: A randomised, placebo-controlled, double-masked clinical trial. https://doi.org/10.1016/j.tvjl.2019.06.006

Pregabalin is the first-line treatment for neuropathic pain (NeP) in humans. Dogs with Chiari-like malformation and syringomyelia (CM/SM) associated with NeP could benefit from pregabalin. The aim of this study was to evaluate the efficacy of pregaba... Read More about Pregabalin for the treatment of syringomyelia-associated neuropathic pain in dogs: A randomised, placebo-controlled, double-masked clinical trial.

Sedative and antinociceptive effects of different detomidine constant rate infusions, with or without methadone in standing horses (2019)
Journal Article
Gozalo-Marcilla, M., Rodrigues De Oliveira, A., Werneck Fonseca, M., Possebon, F. S., Pelligand, L., Taylor, P. M., & Luna, S. P. L. (2019). Sedative and antinociceptive effects of different detomidine constant rate infusions, with or without methadone in standing horses. Equine Veterinary Journal, 51(4), 530-536. https://doi.org/10.1111/evj.13054

VetCAST method for determination of the pharmacokineticpharmacodynamic cut-off values of a long-acting formulation of florfenicol to support clinical breakpoints for florfenicol Antimicrobial Susceptibility Testing in cattle (2019)
Journal Article
Toutain, P., Sidhu, P. K., Lees, P., Rassouli, A., & Pelligand, L. (2019). VetCAST method for determination of the pharmacokineticpharmacodynamic cut-off values of a long-acting formulation of florfenicol to support clinical breakpoints for florfenicol Antimicrobial Susceptibility Testing in cattle. Frontiers in Microbiology, 10(1310), https://doi.org/10.3389/fmicb.2019.01310

The PK/PD cut-off (PK/PDCO ) value of florfenicol for calf pathogens was determined for long acting formulations (MSD Nuflor® and a bioequivalent generic product). PK/PDCO is one of the three MICs considered by VetCAST, a sub-committee of the Europea... Read More about VetCAST method for determination of the pharmacokineticpharmacodynamic cut-off values of a long-acting formulation of florfenicol to support clinical breakpoints for florfenicol Antimicrobial Susceptibility Testing in cattle.

Semi-Mechanistic Modeling of Florfenicol Time-Kill Curves and in silico Dose Fractionation for Calf Respiratory Pathogens (2019)
Journal Article
Pelligand, L., Lees, P., Sidhu, P. K., & Toutain, P. (2019). Semi-Mechanistic Modeling of Florfenicol Time-Kill Curves and in silico Dose Fractionation for Calf Respiratory Pathogens. Frontiers in Microbiology, 10, https://doi.org/10.3389/fmicb.2019.01237

An important application of time-kill curve (TKC) assays is determination of the nature of the best PK/PD index (fAUC/MIC or fT% > MIC) and its target value for predicting clinical efficacy in vivo. VetCAST (the veterinary subcommittee of EUCAST) her... Read More about Semi-Mechanistic Modeling of Florfenicol Time-Kill Curves and in silico Dose Fractionation for Calf Respiratory Pathogens.

A double-blinded randomised dietary supplement crossover trial design to investigate the short-term influence of medium chain fatty acid (MCT) supplement on canine idiopathic epilepsy: study protocol (2019)
Journal Article
Berk, B. A., Packer, R. M. A., Law, T. H., Wessmann, A., Bathen-Nöthen, A., Jokinen, T. S., …Volk, H. A. (2019). A double-blinded randomised dietary supplement crossover trial design to investigate the short-term influence of medium chain fatty acid (MCT) supplement on canine idiopathic epilepsy: study protocol. BMC Veterinary Research, 15(181), https://doi.org/10.1186/s12917-019-1915-8