Glimepiride protects neurons against amyloid-beta-induced synapse damage
(2016)
Journal Article
Osborne, C., West, E., Nolan, W., McHale-Owen, H., Williams, A., & Bate, C. (2016). Glimepiride protects neurons against amyloid-beta-induced synapse damage. Neuropharmacology, 101, 225-236. https://doi.org/10.1016/j.neuropharm.2015.09.030
Outputs (65)
An in vitro model for synaptic loss in neurodegenerative diseases suggests a neuroprotective role for valproic acid via inhibition of cPLA(2) dependent signalling (2016)
Journal Article
Williams, R. S. B., & Bate, C. (2016). An in vitro model for synaptic loss in neurodegenerative diseases suggests a neuroprotective role for valproic acid via inhibition of cPLA(2) dependent signalling. Neuropharmacology, 101, 566-575. https://doi.org/10.1016/j.neuropharm.2015.06.013Many neurodegenerative diseases present the loss of synapses as a common pathological feature. Here we have employed an in vitro model for synaptic loss to investigate the molecular mechanism of a therapeutic treatment, valproic acid (VPA). We show t... Read More about An in vitro model for synaptic loss in neurodegenerative diseases suggests a neuroprotective role for valproic acid via inhibition of cPLA(2) dependent signalling.
Sialic Acid on the Glycosylphosphatidylinositol Anchor Regulates PrP-mediated Cell Signaling and Prion Formation (2016)
Journal Article
Bate, C., Nolan, W., McHale-Owen, H., & Williams, A. (2016). Sialic Acid on the Glycosylphosphatidylinositol Anchor Regulates PrP-mediated Cell Signaling and Prion Formation. Journal of Biological Chemistry, 291(33), 17093-17101. https://doi.org/10.1074/jbc.M116.731117The prion diseases occur following the conversion of the cellular prion protein (PrPC) into disease-related isoforms (PrPSc). In this study, the role of the glycosylphosphatidylinositol (GPI) anchor attached to PrPC in prion formation was examined us... Read More about Sialic Acid on the Glycosylphosphatidylinositol Anchor Regulates PrP-mediated Cell Signaling and Prion Formation.
Phospholipase A(2) inhibitors protect against prion and A beta mediated synapse degeneration
Journal Article
Bate, C., Tayebi, M., & Williams, A. Phospholipase A(2) inhibitors protect against prion and A beta mediated synapse degeneration. Molecular Neurodegeneration, 5(13), https://doi.org/10.1186/1750-1326-5-13
Glycosylphosphatidylinositol Anchor Analogues Sequester Cholesterol and Reduce Prion Formation
Journal Article
Bate, C., Tayebi, M., & Williams, A. Glycosylphosphatidylinositol Anchor Analogues Sequester Cholesterol and Reduce Prion Formation. Journal of Biological Chemistry, 285(29), 22017-22026. https://doi.org/10.1074/jbc.M110.108548
Polyunsaturated Fatty Acids Protect Against Prion-Mediated Synapse Damage In Vitro
Journal Article
Bate, C., Tayebi, M., Salmona, M., Diomede, L., & Williams, A. Polyunsaturated Fatty Acids Protect Against Prion-Mediated Synapse Damage In Vitro. Neurotoxicity Research, 17(3), 203-214. https://doi.org/10.1007/s12640-009-9093-2
Alpha-synuclein induced synapse damage is enhanced by amyloid-beta
Journal Article
Bate, C., Gentleman, S., & Williams, A. Alpha-synuclein induced synapse damage is enhanced by amyloid-beta. Molecular Neurodegeneration, 5(55), https://doi.org/10.1186/1750-1326-5-55
The cellular prion protein with a monoacylated glycosylphosphatidylinositol anchor modifies cell membranes, inhibits cell signaling and reduces prion formation
Journal Article
Bate, C., & Williams, A. The cellular prion protein with a monoacylated glycosylphosphatidylinositol anchor modifies cell membranes, inhibits cell signaling and reduces prion formation. Prion, 5(2), 65-68. https://doi.org/10.4161/pri.5.2.16095
Monoacylated Cellular Prion Protein Modifies Cell Membranes, Inhibits Cell Signaling, and Reduces Prion Formation
Journal Article
Bate, C., & Williams, A. Monoacylated Cellular Prion Protein Modifies Cell Membranes, Inhibits Cell Signaling, and Reduces Prion Formation. Journal of Biological Chemistry, 286(11), 8752-8758. https://doi.org/10.1074/jbc.M110.186833
Docosahexaenoic and eicosapentaenoic acids increase neuronal death in response to HuPrP82-146 and A beta 1-42
Journal Article
Bate, C., Marshall, V., Colombo, L., Diomede, L., Salmona, M., & Williams, A. Docosahexaenoic and eicosapentaenoic acids increase neuronal death in response to HuPrP82-146 and A beta 1-42. Neuropharmacology, 54(6), 934-943. https://doi.org/10.1016/j.neuropharm.2008.02.003Dietary supplements containing polyunsaturated fatty acids (PUFA) are frequently taken for their perceived health benefits including a possible reduction in cognitive decline in the elderly. Here we report that pre-treatment with docosahexaenoic acid... Read More about Docosahexaenoic and eicosapentaenoic acids increase neuronal death in response to HuPrP82-146 and A beta 1-42.