Pathobiology and Population Sciences

Exposure to environmental stressors result in increased viral load and further reduction of production parameters in pigs experimentally infected with PCV2b (2015)
Journal Article
Patterson, R., Nevel, M., Diaz, A. V., Martineau, H. M., Demmers, T. G. M., Browne, C., …Werling, D. (2015). Exposure to environmental stressors result in increased viral load and further reduction of production parameters in pigs experimentally infected with PCV2b. Veterinary Microbiology, 177(3-4), 261-269. https://doi.org/10.1016/j.vetmic.2015.03.010

Porcine circovirus type 2 (PCV2) has been identified as the essential, but not sole, underlying infectious component for PCV-associated diseases (PCVAD). Several co-factors have been suggested to convert an infection with PCV2 into the clinical signs... Read More about Exposure to environmental stressors result in increased viral load and further reduction of production parameters in pigs experimentally infected with PCV2b.

A Prospective, Randomized, Blinded, Placebo-Controlled Pilot Study on the Effect of Enterococcus faecium on Clinical Activity and Intestinal Gene Expression in Canine Food-Responsive Chronic Enteropathy (2015)
Journal Article
Schmitz, S., Glanemann, B., Garden, O. A., Brooks, H. W., Chang, Y. M., Werling, D., & Allenspach, K. (2015). A Prospective, Randomized, Blinded, Placebo-Controlled Pilot Study on the Effect of Enterococcus faecium on Clinical Activity and Intestinal Gene Expression in Canine Food-Responsive Chronic Enteropathy. Journal of Veterinary Internal Medicine, 29(2), 533-43. https://doi.org/10.1111/jvim.12563

Two TIR-like domain containing proteins in a newly emerging zoonotic Staphylococcus aureus strain sequence type 398 are potential virulence factors by impacting on the host innate immune response (2014)
Journal Article
Patterson, N. J., Günther, J., Gibson, A. J., Offord, V., Coffey, T. J., Splitter, G., …Werling, D. (2014). Two TIR-like domain containing proteins in a newly emerging zoonotic Staphylococcus aureus strain sequence type 398 are potential virulence factors by impacting on the host innate immune response. Frontiers in Microbiology, 5(662), https://doi.org/10.3389/fmicb.2014.00662

Staphylococcus aureus, sequence type (ST) 398, is an emerging pathogen and the leading cause of livestock-associated methicillin-resistant S. aureus infections in Europe and North America. This strain is characterized by high promiscuity in terms of... Read More about Two TIR-like domain containing proteins in a newly emerging zoonotic Staphylococcus aureus strain sequence type 398 are potential virulence factors by impacting on the host innate immune response.

Association between nucleotide oligomerisation domain two(Nod2) gene polymorphisms and canine inflammatory bowel disease (2014)
Journal Article
Kathrani, A., Lee, H., White, C., Catchpole, B., Murphy, A. M., German, A., …Allenspach, K. (2014). Association between nucleotide oligomerisation domain two(Nod2) gene polymorphisms and canine inflammatory bowel disease. Veterinary Immunology and Immunopathology, 161(1-2), 32-41. https://doi.org/10.1016/j.vetimm.2014.06.003

The most important genetic associations that have been implicated to play a role in the etiology of Crohn's disease (CD) in humans are single nucleotide polymorphisms (SNPs) in nucleotide oligomerisation domain 2 (NOD2). The aim of this study was to... Read More about Association between nucleotide oligomerisation domain two(Nod2) gene polymorphisms and canine inflammatory bowel disease.

Global Gene Expression Profiling of Myeloid Immune Cell Subsets in Response to In Vitro Challenge with Porcine Circovirus 2b (2014)
Journal Article
Mavrommatis, B., Offord, V., Patterson, R., Watson, M., Kanellos, T., Steinbach, F., …Werling, D. (2014). Global Gene Expression Profiling of Myeloid Immune Cell Subsets in Response to In Vitro Challenge with Porcine Circovirus 2b. PLoS ONE, 9(3), e91081. https://doi.org/10.1371/journal.pone.0091081

Compelling evidence suggests that the early interaction between porcine circovirus 2 (PCV-2) and the innate immune system is the key event in the pathogenesis of Post-Weaning Multisystemic Wasting Syndrome (PMWS). Furthermore, PCV2 has been detected... Read More about Global Gene Expression Profiling of Myeloid Immune Cell Subsets in Response to In Vitro Challenge with Porcine Circovirus 2b.

Yeast-surface expressed BVDV E2 protein induces a Th1/Th2 response in naïve T cells (2012)
Journal Article
Patterson, R., Nerren, J., Kogut, M., Court, P., Villarreal-Ramos, B., Seyfert, H. M., …Werling, D. (2012). Yeast-surface expressed BVDV E2 protein induces a Th1/Th2 response in naïve T cells. Developmental and Comparative Immunology, 37(1), 107-114. https://doi.org/10.1016/j.dci.2011.10.009

Yeast species such as Saccharomyces cerevisiae are known to be potent activators of the immune system. S. cerevisiae activates the innate immune system by engaging pattern recognition receptors such as toll like receptor 2 (TLR2) and dectin-1. In the... Read More about Yeast-surface expressed BVDV E2 protein induces a Th1/Th2 response in naïve T cells.

Assessment and quantification of post-weaning multi-systemic wasting syndrome severity at farm level
Journal Article
Alarcon, P., Velasova, M., Werling, D., Staerk, K. D. C., Chang, Y. M., Nevel, M., …Wieland, B. Assessment and quantification of post-weaning multi-systemic wasting syndrome severity at farm level. Preventive Veterinary Medicine, 98(1), 19-28. https://doi.org/10.1016/j.prevetmed.2010.09.022

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