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Genetic Consequences of Mass Human Chemotherapy for Schistosoma mansoni: Population Structure Pre- and Post-Praziquantel Treatment in Tanzania
Journal Article
Norton, A. J., Gower, C. M., Lamberton, P. H. L., Webster, B. L., Lwambo, N. J. S., Blair, L., …Webster, J. P. Genetic Consequences of Mass Human Chemotherapy for Schistosoma mansoni: Population Structure Pre- and Post-Praziquantel Treatment in Tanzania. American Journal of Tropical Medicine and Hygiene, 83(4), 951-957. https://doi.org/10.4269/ajtmh.2010.10-0283

Oxamniquine resistance alleles are widespread in Old World Schistosoma mansoni and predate drug deployment
Journal Article
Chevalier, F. D., Le Clec’h, W., McDew-White, M., Menon, V., Guzman, M. A., Holloway, S. P., …Anderson, T. J. C. (in press). Oxamniquine resistance alleles are widespread in Old World Schistosoma mansoni and predate drug deployment. PLoS Pathogens, 15(10), https://doi.org/10.1371/journal.ppat.1007881

Do mutations required for adaptation occur de novo, or are they segregating within populations as standing genetic variation? This question is key to understanding adaptive change in nature, and has important practical consequences for the evolution... Read More about Oxamniquine resistance alleles are widespread in Old World Schistosoma mansoni and predate drug deployment.

Ancient hybridization and adaptive introgression of an invadolysin gene in schistosome parasites
Journal Article
Platt, R. N., McDew-White, M., Le Clec'H, W., Chevalier, F. D., Allan, F., Emery, A. M., …Anderson, T. J. C. (in press). Ancient hybridization and adaptive introgression of an invadolysin gene in schistosome parasites. Molecular Biology and Evolution, 36(10), 2127-2142. https://doi.org/10.1093/molbev/msz154

Introgression among parasite species has the potential to transfer traits of biomedical importance across species boundaries. The parasitic blood fluke Schistosoma haematobium causes urogenital schistosomiasis in humans across sub-Saharan Africa. Hyb... Read More about Ancient hybridization and adaptive introgression of an invadolysin gene in schistosome parasites.

Plagiorchis sp. in small mammals of Senegal and the potential emergence of a zoonotic trematodiasis
Journal Article
Catalano, S., Nadler, S. A., Fall, C. B., Marsh, K. J., Léger, E., Sène, M., …Webster, J. P. (in press). Plagiorchis sp. in small mammals of Senegal and the potential emergence of a zoonotic trematodiasis. International Journal for Parasitology, 8, 164-170. https://doi.org/10.1016/j.ijppaw.2019.02.003

Trematodes of the genus Plagiorchis have a wide geographical distribution and can exploit a variety of hosts. The occurrence and zoonotic potential of Plagiorchis spp. have been characterised across several countries in Asia; in contrast, information... Read More about Plagiorchis sp. in small mammals of Senegal and the potential emergence of a zoonotic trematodiasis.

Diagnosis and drug resistance of human soil-transmitted helminth infections: A public health perspective
Journal Article
Mutombo, P. N., Man, N. W. Y., Nejsum, P., Ricketson, R., Gordon, C. A., Robertson, G., …McLaws, M. Diagnosis and drug resistance of human soil-transmitted helminth infections: A public health perspective. https://doi.org/10.1016/bs.apar.2019.02.004

Soil-transmitted helminth (STH) infections represent a major public health problem globally, particularly among socio-economically disadvantaged populations. Detection of STH infections is often challenging, requiring a combination of diagnostic tech... Read More about Diagnosis and drug resistance of human soil-transmitted helminth infections: A public health perspective.