Outputs (48)

Towards an integrated food safety surveillance system: a simulation study to explore the potential of combining genomic and epidemiological metadata (2017)
Journal Article
Hill, A. A., Crotta, M., Wall, B., Good, L., O'Brien, S. J., & Guitian, J. (2017). Towards an integrated food safety surveillance system: a simulation study to explore the potential of combining genomic and epidemiological metadata. Royal Society Open Science, 4, https://doi.org/10.1098/rsos.160721

Foodborne infection is a result of exposure to complex, dynamic food systems. The efficiency of foodborne infection is driven by ongoing shifts in genetic machinery. Next-generation sequencing technologies can provide high-fidelity data about the gen... Read More about Towards an integrated food safety surveillance system: a simulation study to explore the potential of combining genomic and epidemiological metadata.

Disruption of Higher Order DNA Structures in Friedreich's Ataxia (GAA)n Repeats by PNA or LNA Targeting (2016)
Journal Article
Bergquist, H., Rocha, C. S., Alvarez-Asencio, R., Nguyen, C. H., Rutland, M. W., Smith, C. I., …Zain, R. (2016). Disruption of Higher Order DNA Structures in Friedreich's Ataxia (GAA)n Repeats by PNA or LNA Targeting. PLoS ONE, 15(11), e0165788. https://doi.org/10.1371/journal.pone.0165788

Expansion of (GAA)n repeats in the first intron of the Frataxin gene is associated with reduced mRNA and protein levels and the development of Friedreich’s ataxia. (GAA)n expansions form non-canonical structures, including intramolecular triplex (H-D... Read More about Disruption of Higher Order DNA Structures in Friedreich's Ataxia (GAA)n Repeats by PNA or LNA Targeting.

Biomarkers of browning of white adipose tissue and their regulation during exercise- and diet-induced weight loss (2016)
Journal Article
Nakhuda, A., Josse, A. R., Gburcik, V., Crossland, H., Raymond, F., Metairon, S., …Timmons, J. A. (2016). Biomarkers of browning of white adipose tissue and their regulation during exercise- and diet-induced weight loss. American Journal of Clinical Nutrition, 104(3), 557-565. https://doi.org/10.3945/ajcn.116.132563

Biomarkers of browning of white adipose tissue and their regulation during exercise- and diet-induced weight loss (2016)
Journal Article
Nakhuda, A., Josse, A. R., Gburcik, V., Crossland, H., Raymond, F., Metairon, S., …Timmons, J. A. (2016). Biomarkers of browning of white adipose tissue and their regulation during exercise- and diet-induced weight loss. American Journal of Clinical Nutrition, 104(3), 557-565. https://doi.org/10.3945/ajcn.116.132563

The antimicrobial polymer PHMB enters cells and selectively condenses bacterial chromosomes (2016)
Journal Article
Chindera, K., Mahato, M., Sharma, A. K., Horsley, H., Kloc-Muniak, K., Kamaruzzaman, N. F., …Good, L. (2016). The antimicrobial polymer PHMB enters cells and selectively condenses bacterial chromosomes. https://doi.org/10.1038/srep23121

Bactericidal effects of polyhexamethylene biguanide against intracellular Staphylococcus aureus EMRSA-15 and USA 300 (2016)
Journal Article
Kamaruzzaman, N. F., Firdessa, R., & Good, L. (2016). Bactericidal effects of polyhexamethylene biguanide against intracellular Staphylococcus aureus EMRSA-15 and USA 300. Journal of Antimicrobial Chemotherapy, 71(5), 1252-1259. https://doi.org/10.1093/jac/dkv474

Interaction of the tetracyclines with double-stranded RNAs of random base sequence: new perspectives on the target and mechanism of action (2016)
Journal Article
Chukwudi, C. U., & Good, L. (2016). Interaction of the tetracyclines with double-stranded RNAs of random base sequence: new perspectives on the target and mechanism of action. Journal of Antibiotics, 69, 622-630. https://doi.org/10.1038/ja.2015.145

The 16S rRNA binding mechanism proposed for the antibacterial action of the tetracyclines does not explain their mechanism of action against non-bacterial pathogens. In addition, several contradictory base pairs have been proposed as their binding si... Read More about Interaction of the tetracyclines with double-stranded RNAs of random base sequence: new perspectives on the target and mechanism of action.

Oxacillin sensitization of methicillin-resistant Staphylococcus aureus and methicillin-resistant Staphylococcus pseudintermedius by antisense peptide nucleic acids in vitro (2015)
Journal Article
Goh, S., Loeffler, A., Lloyd, D. H., Nair, S., & Good, L. (2015). Oxacillin sensitization of methicillin-resistant Staphylococcus aureus and methicillin-resistant Staphylococcus pseudintermedius by antisense peptide nucleic acids in vitro. BMC Microbiology, 15(1), 262. https://doi.org/10.1186/s12866-015-0599-x

Oxacillin sensitization of methicillin-resistant Staphylococcus aureus and methicillin-resistant Staphylococcus pseudintermedius by antisense peptide nucleic acids in vitro (2015)
Journal Article
Goh, S., Loeffler, A., Lloyd, D. H., Nair, S., & Good, L. (2015). Oxacillin sensitization of methicillin-resistant Staphylococcus aureus and methicillin-resistant Staphylococcus pseudintermedius by antisense peptide nucleic acids in vitro. BMC Microbiology, 15(1), 262. https://doi.org/10.1186/s12866-015-0599-x

Pathogen- and Host-Directed Antileishmanial Effects Mediated by Polyhexanide (PHMB) (2015)
Journal Article
Firdessa, R., Good, L., Amstalden, M. C., Chindera, K., Kamaruzzaman, N. F., Schultheis, M., …Moll, H. (2015). Pathogen- and Host-Directed Antileishmanial Effects Mediated by Polyhexanide (PHMB). PLoS Neglected Tropical Diseases, 9(10), https://doi.org/10.1371/journal.pntd.0004041