Pathobiology and Population Sciences

The Population Biology and Transmission Dynamics of Loa loa (2018)
Journal Article
Whittaker, C., Walker, M., Pion, S. D. S., Chesnais, C. B., Boussinesq, M., & Basáñez, M. (2018). The Population Biology and Transmission Dynamics of Loa loa. Trends in Parasitology, https://doi.org/10.1016/j.pt.2017.12.003

Endemic to Central Africa, loiasis – or African eye worm (caused by the filarial nematode Loa loa) – affects more than 10 million people. Despite causing ocular and systemic symptoms, it has typically been considered a benign condition, only of publi... Read More about The Population Biology and Transmission Dynamics of Loa loa.

In vivo testing of novel vaccine prototypes against Actinobacillus pleuropneumoniae (2018)
Journal Article
Antenucci, F., Fougeroux, C., Deeney, A., Orskov, C., Rycroft, A. N., Holst, P. J., & Bojesen, A. M. (2018). In vivo testing of novel vaccine prototypes against Actinobacillus pleuropneumoniae. Veterinary Research, 49, 4. https://doi.org/10.1186/s13567-017-0502-x

Actinobacillus pleuropneumoniae (A. pleuropneumoniae) is a Gram-negative bacterium that represents the main cause of porcine pleuropneumonia in pigs, causing significant economic losses to the livestock industry worldwide. A. pleuropneumoniae, as the... Read More about In vivo testing of novel vaccine prototypes against Actinobacillus pleuropneumoniae.

Characterisation of porcine circovirus type 2 in porcine circovirus disease cases in England and Wales (2018)
Journal Article
Grierson, S. S., Werling, D., Bidewell, C., & Williamson, S. (2018). Characterisation of porcine circovirus type 2 in porcine circovirus disease cases in England and Wales. Veterinary Record, 182(1), 22. https://doi.org/10.1136/vr.104450

Confirmed cases of porcine circovirus disease (PCVD) in Great Britain have shown a steady decline since the availability of porcine circovirus type 2 (PCV2) vaccines. However, PCVD is still occasionally diagnosed. The authors carried out a genotyping... Read More about Characterisation of porcine circovirus type 2 in porcine circovirus disease cases in England and Wales.

Use of proteins identified through a functional genomic screen to develop a protein subunit vaccine that provides significant protection against virulent Streptococcus suis in pigs (2018)
Journal Article
Brockmeier, S. L., Loving, C. L., Nicholson, T. L., Wang, J., Peters, S. E., Weinert, L., …Tucker, A. W. (2018). Use of proteins identified through a functional genomic screen to develop a protein subunit vaccine that provides significant protection against virulent Streptococcus suis in pigs. Infection and Immunity, 86(3), e00559. https://doi.org/10.1128/IAI.00559-17

Streptococcus suis is a bacterium that is commonly carried in the respiratory tract and that is also one of the most important invasive pathogens of swine, commonly causing meningitis, arthritis, and septicemia. Due to the existence of many serotypes... Read More about Use of proteins identified through a functional genomic screen to develop a protein subunit vaccine that provides significant protection against virulent Streptococcus suis in pigs.

Valproic acid and its congener propylisopropylacetic acid reduced the amount of soluble amyloid-ß oligomers released from 7PA2 cells (2018)
Journal Article
Williams, R. S. B., & Bate, C. (2018). Valproic acid and its congener propylisopropylacetic acid reduced the amount of soluble amyloid-ß oligomers released from 7PA2 cells. Neuropharmacology, 128, 54-62. https://doi.org/10.1016/j.neuropharm.2017.09.031

The amyloid hypothesis of Alzheimer's disease suggests that synaptic degeneration and pathology is caused by the accumulation of amyloid-β (Aβ) peptides derived from the amyloid precursor protein (APP). Subsequently, soluble Aβ oligomers cause the lo... Read More about Valproic acid and its congener propylisopropylacetic acid reduced the amount of soluble amyloid-ß oligomers released from 7PA2 cells.

Identification of production challenges and benefits using value chain mapping of egg food systems in Nairobi, Kenya (2018)
Journal Article
Onono, J. O., Alarcon, P., Karani, M., Muinde, P., Akoko, J. M., Maud, C., …Rushton, J. (2018). Identification of production challenges and benefits using value chain mapping of egg food systems in Nairobi, Kenya. Agricultural Systems, 159, 1-8. https://doi.org/10.1016/j.agsy.2017.10.001

Commercial layer and indigenous chicken farming in Nairobi and associated activities in the egg value chains are a source of livelihood for urban families. A value chain mapping framework was used to describe types of inputs and outputs from chicken... Read More about Identification of production challenges and benefits using value chain mapping of egg food systems in Nairobi, Kenya.

A probabilistic approach to the interpretation of milk antibody results for diagnosis of Johne’s disease in dairy cattle (2018)
Journal Article
Meyer, A., Bond, K., Van Winden, S. C. L., Green, M., & Guitian, J. (2018). A probabilistic approach to the interpretation of milk antibody results for diagnosis of Johne’s disease in dairy cattle. Preventive Veterinary Medicine, 150, 30-37. https://doi.org/10.1016/j.prevetmed.2017.11.016

Johne’s disease is a serious wasting disease of ruminants that is of high economic importance for the dairy sector in particular. The chronic nature of the disease, the fluctuations in antibody levels and the limited ability of diagnostic tests to id... Read More about A probabilistic approach to the interpretation of milk antibody results for diagnosis of Johne’s disease in dairy cattle.

Cholesterol ester hydrolase inhibitors reduce the production of synaptotoxic amyloid-beta oligomers (2018)
Journal Article
McHale-Owen, H., & Bate, C. (2018). Cholesterol ester hydrolase inhibitors reduce the production of synaptotoxic amyloid-beta oligomers. https://doi.org/10.1016/j.bbadis.2017.12.017

The production of amyloid-β (Aβ) is the key factor driving pathogenesis in Alzheimer's disease (AD). Increasing concentrations of Aβ within the brain cause synapse degeneration and the dementia that is characteristic of AD. Here the factors that affe... Read More about Cholesterol ester hydrolase inhibitors reduce the production of synaptotoxic amyloid-beta oligomers.

Polymorphisms in the canine IL7R 3 ' UTR are associated with thymic output in Labrador retriever dogs and influence post-transcriptional regulation by microRNA 185 (2018)
Journal Article
Holder, A. L., Jones, G., Soutter, F., Palmer, D. B., Aspinall, R., & Catchpole, B. (2018). Polymorphisms in the canine IL7R 3 ' UTR are associated with thymic output in Labrador retriever dogs and influence post-transcriptional regulation by microRNA 185. Developmental and Comparative Immunology, 81, 244-251. https://doi.org/10.1016/j.dci.2017.12.008

Interleukin-7 (IL-7) and its receptor (IL-7R) are essential for T cell development in the thymus, and changes in the IL-7/IL-7R pathway have been implicated in age-associated thymic involution which results in a reduction of naïve T cell output. The... Read More about Polymorphisms in the canine IL7R 3 ' UTR are associated with thymic output in Labrador retriever dogs and influence post-transcriptional regulation by microRNA 185.

Outputs (162)