Targeting the Bacterial Protective Armour; Challenges and Novel Strategies in the Treatment of Microbial Biofilm

Kamaruzzaman, F N; Tan, P L; Mat Yazid, A K; Saeed, I S; Hamdan, H R; Choong, S S; Wong, K W; Chivu, A; Gibson, J A

Abstract

Infectious disease caused by pathogenic bacteria continues to be the primary challenge to humanity. Antimicrobial resistance and microbial biofilm formation in part, lead to treatment failures. The formation of biofilms by nosocomial pathogens such as Staphylococcus aureus (S. aureus), Pseudomonas aeruginosa (P. aeruginosa), and Klebsiella pneumoniae (K. pneumoniae) on medical devices and on the surfaces of infected sites bring additional hurdles to existing therapies. In this review, we discuss the challenges encountered by conventional treatment strategies in the clinic. We also provide updates on current on-going research related to the development of novel anti-biofilm technologies. We intend for this review to provide understanding to readers on the current problem in health-care settings and propose new ideas for new intervention strategies to reduce the burden related to microbial infections.

Citation

Kamaruzzaman, F. N., Tan, P. L., Mat Yazid, A. K., Saeed, I. S., Hamdan, H. R., Choong, S. S., …Gibson, J. A. (in press). Targeting the Bacterial Protective Armour; Challenges and Novel Strategies in the Treatment of Microbial Biofilm. Materials, 11(9), 1705. https://doi.org/10.3390/ma11091705

• Journal Article Type: Article
• Acceptance Date: Sep 9, 2018
• Deposit Date: Mar 8, 2019
• Publicly Available Date: Nov 21, 2020
• Journal: Materials
• Publisher: MDPI
• Peer Reviewed: Peer Reviewed
• Volume: 11
• Issue: 9
• Pages: 1705
• DOI: https://doi.org/10.3390/ma11091705
• Public URL: https://rvc-repository.worktribe.com/output/1385933