COVID-19 Genomics UK COG-UK Consor
Generation and transmission of interlineage recombinants in the SARS-CoV-2 pandemic
COVID-19 Genomics UK COG-UK Consor; Jackson, B; Boni, MF; Bull, MJ; Colleran, A; Colquhoun, RM; Darby, AC; Haldenby, S; Hill, V; Lucaci, A; McCrone, JT; Nicholls, SM; O'Toole, A; Pacchiarini, N; Poplawski, R; Scher, E; Todd, F; Webster, HJ; Whitehead, M; Wierzbicki, C; Loman, NJ; Connor, TR; Robertson, DL; Pybus, OG; Rambaut, A
Authors
B Jackson
MF Boni
MJ Bull
A Colleran
RM Colquhoun
AC Darby
S Haldenby
V Hill
A Lucaci
JT McCrone
SM Nicholls
A O'Toole
N Pacchiarini
R Poplawski
E Scher
F Todd
HJ Webster
M Whitehead
C Wierzbicki
NJ Loman
TR Connor
DL Robertson
OG Pybus
A Rambaut
Abstract
We present evidence for multiple independent origins of recombinant SARS-CoV-2 viruses sampled from late 2020 and early 2021 in the United Kingdom. Their genomes carry single-nucleotide polymorphisms and deletions that are characteristic of the B.1.1.7 variant of concern but lack the full complement of lineagedefining mutations. Instead, the remainder of their genomes share contiguous genetic variation with non-B.1.1.7 viruses circulating in the same geographic area at the same time as the recombinants. In four instances, there was evidence for onward transmission of a recombinant-origin virus, including one transmission cluster of 45 sequenced cases over the course of 2 months. The inferred genomic locations of recombination breakpoints suggest that every community-transmitted recombinant virus inherited its spike region from a B.1.1.7 parental virus, consistent with a transmission advantage for B.1.1.7's set of mutations.
Citation
COVID-19 Genomics UK COG-UK Consor, Jackson, B., Boni, M., Bull, M., Colleran, A., Colquhoun, R., …Rambaut, A. (2021). Generation and transmission of interlineage recombinants in the SARS-CoV-2 pandemic. Cell, 184(20), 5179-+. https://doi.org/10.1016/j.cell.2021.08.014
Journal Article Type | Article |
---|---|
Acceptance Date | Aug 11, 2021 |
Publication Date | 2021 |
Deposit Date | Jan 11, 2022 |
Publicly Available Date | Jan 11, 2022 |
Print ISSN | 0092-8674 |
Publisher | Elsevier |
Peer Reviewed | Peer Reviewed |
Volume | 184 |
Issue | 20 |
Pages | 5179-+ |
DOI | https://doi.org/10.1016/j.cell.2021.08.014 |
Keywords | RNA RECOMBINATION; MOLECULAR-BIOLOGY; CORONAVIRUS; ORIGIN; VIRUS |
Public URL | https://rvc-repository.worktribe.com/output/1555197 |
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