AJ Malbon
Alzheimer-like pathology in the parietal cortex and hippocampus of aged donkeys
Malbon, AJ; Sordo, L; Wilson, LA; Gunn-Moore, D; Paraschou, G; Macintyre, N; Schwarz, T; McGorum, B; Hahn, C
Authors
L Sordo
LA Wilson
D Gunn-Moore
G Paraschou
N Macintyre
T Schwarz
B McGorum
C Hahn
Abstract
Neurodegenerative disorders are gaining ever more importance in ageing populations of animals and people. Altered insulin signaling and type II diabetes have been linked to the development of Alzheimer's disease (AD) in humans and AD-like neurodegeneration in other long-lived animals. Donkeys are unusual amongst domestic species for their exceptional longevity and are additionally predisposed to abnormalities of insulin metabolism similar to those found in humans. In this study, the parietal lobe and hippocampus of 13 aged ( > 30 years) and 2 younger control donkeys were evaluated immunohistologically for the presence, distribution, and frequency of neurofibrillary tangles (NFT) and amyloid plaques (AP); the characteristic lesions of AD. AP were in parietal cortices of 9 donkeys, with a predilection for deep sulci, and NFT-like structures were observed in 7 donkeys, primarily within cortical areas. No changes were observed in the control donkeys. This represents the first identification of both AP and NFT in equids and is a stimulus for future work assessing their metabolic status in parallel.(c) 2022 Elsevier Inc. All rights reserved.
Citation
Malbon, A., Sordo, L., Wilson, L., Gunn-Moore, D., Paraschou, G., Macintyre, N., …Hahn, C. (2022). Alzheimer-like pathology in the parietal cortex and hippocampus of aged donkeys. Neurobiology of Aging, 113, 7-14. https://doi.org/10.1016/j.neurobiolaging.2022.01.007
Journal Article Type | Article |
---|---|
Acceptance Date | Jan 26, 2022 |
Publication Date | 2022 |
Deposit Date | Jul 28, 2023 |
Print ISSN | 0197-4580 |
Publisher | Elsevier |
Peer Reviewed | Peer Reviewed |
Volume | 113 |
Pages | 7-14 |
DOI | https://doi.org/10.1016/j.neurobiolaging.2022.01.007 |
Keywords | Donkey; Neurodegeneration; Alzheimer's; Neurofibrillary tangles; Amyloid plaques; POSTREPRODUCTIVE LIFE-SPAN; BETA-AMYLOID DEPOSITION; NEUROFIBRILLARY TANGLES; DISEASE; BRAINS; DYSFUNCTION; ANIMALS; PROTEIN; UPDATE; MODEL |
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