Image-based multiplex immune profiling of cancer tissues: translational implications. A report of the International Immuno-oncology Biomarker Working Group on Breast Cancer

Jahangir, CA; Page, DB; Broeckx, G; Gonzalez, CA; Burke, C; Murphy, C; Reis, JS; Ly, A; Harms, PW; Gupta, RR; Vieth, M; Hida, A; Kahila, M; Kos, Z; van Diest, PJ; Verbandt, S; Thagaard, J; Khiroya, R; Abduljabbar, K; Haab, GA; Acs, B; Adams, S; Almeida, JS; Alvarado-Cabrero, I; Azmoudeh-Ardalan, F; Badve, S; Baharun, NB; Bellolio, ER; Bheemaraju, V; Blenman, KRM; Fujimoto, LBM; Burgues, O; Chardas, A; Cheang, MCU; Ciompi, F; Cooper, LA; Coosemans, A; Corredor, G; Portela, FLD; Deman, F; Demaria, S; Dudgeon, SN; Elghazawy, M; Fernandez-Martín, C; Fineberg, S; Fox, SB; Giltnane, JM; Gnjatic, S; Gonzalez-Ericsson, P; Grigoriadis, A; Halama, N; Hanna, MG; Harbhajanka, A; Hart, SN; Hartman, J; Hewitt, S; Horlings, HM; Husain, Z; Irshad, S; Janssen, EAM; Kataoka, TR; Kawaguchi, K; Khramtsov, A; Kiraz, U; Kirtani, P; Kodach, LL; Korski, K; Akturk, G; Scott, E; Kovács, A; Lænkholm, AV; Lang-Schwarz, C; Larsimont, D; Lennerz, JK; Lerousseau, M; Li, XX; Madabhushi, A; Maley, SK; Narasimhamurthy, VM; Marks, DK; McDonald, ES; Mehrotra, R; Michiels, S; Kharidehal, D; Minhas, FUA; Mittal, S; Moore, DA; Mushtaq, S; Nighat, H; Papathomas, T; Penault-Llorca, F; Perera, RD; Pinard, CJ; Pinto-Cardenas, JC; Pruneri, G; Pusztai, L; Rajpoot, NM; Rapoport, BL; Rau, TT; Ribeiro, JM; Rimm, D; Vincent-Salomon, A; Saltz, J; Sayed, S; Hytopoulos, E; Mahon, S; Siziopikou, KP; Sotiriou, C; Stenzinger, A; Sughayer, MA; Sur, D; Symmans, F; Tanaka, S; Taxter, T; Tejpar, S; Teuwen, J; Thompson, EA; Tramm, T; Tran, WT; van der Laak, J; Verghese, GE; Viale, G; Wahab, N; Walter, T; Waumans, Y; Wen, HY; Yang, WT; Yuan, YY; Bartlett, J; Loibl, S; Denkert, C; Savas, P; Stovgaard, E; Stovgaard, ES; Salgado, R; Gallagher, WM; Rahman, A

doi:10.1002/path.6238

All Outputs (2)

A CADASIL NOTCH3 mutation leads to clonal hematopoiesis and expansion of Dnmt3a-R878H hematopoietic clones (2024)
Journal Article
Sánchez-Lanzas, R., Barclay, J., Chardas, A., Kalampalika, F., Jiménez-Pompa, A., Gallipoli, P., & Ganuza, M. (2024). A CADASIL NOTCH3 mutation leads to clonal hematopoiesis and expansion of Dnmt3a-R878H hematopoietic clones. Leukemia, https://doi.org/10.1038/s41375-024-02464-8

Clonal hematopoiesis (CH) is nearly universal in the elderly. The molecular and cellular mechanisms driving CH and the clinical consequences of carrying clonally derived mutant mature blood cells are poorly understood. We recently identified a C223Y... Read More about A CADASIL NOTCH3 mutation leads to clonal hematopoiesis and expansion of Dnmt3a-R878H hematopoietic clones.

Image-based multiplex immune profiling of cancer tissues: translational implications. A report of the International Immuno-oncology Biomarker Working Group on Breast Cancer (2024)
Journal Article
Jahangir, C., Page, D., Broeckx, G., Gonzalez, C., Burke, C., Murphy, C., Reis, J., Ly, A., Harms, P., Gupta, R., Vieth, M., Hida, A., Kahila, M., Kos, Z., van Diest, P., Verbandt, S., Thagaard, J., Khiroya, R., Abduljabbar, K., Haab, G., …Rahman, A. (2024). Image-based multiplex immune profiling of cancer tissues: translational implications. A report of the International Immuno-oncology Biomarker Working Group on Breast Cancer. Journal of Pathology, 262(3), 271-288. https://doi.org/10.1002/path.6238

Recent advances in the field of immuno-oncology have brought transformative changes in the management of cancer patients. The immune profile of tumours has been found to have key value in predicting disease prognosis and treatment response in various... Read More about Image-based multiplex immune profiling of cancer tissues: translational implications. A report of the International Immuno-oncology Biomarker Working Group on Breast Cancer.