The Tumor Suppressor CYLD Inhibits Mammary Epithelial to Mesenchymal Transition by the Coordinated Inhibition of YAP/TAZ and TGFβ Signaling

Pseftogas, A; Xanthopoulos, K; Poutahidis, T; Ainali, C; Dafou, D; Panteris, E; Kern, JG; Varelas, X; Hardas, A; Gonidas, C; Tsingotjidou, A; Hatzivassiliou, E; Mosialos, G

doi:10.3390/cancers12082047

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The Tumor Suppressor CYLD Inhibits Mammary Epithelial to Mesenchymal Transition by the Coordinated Inhibition of YAP/TAZ and TGFβ Signaling (2020)
Journal Article
Pseftogas, A., Xanthopoulos, K., Poutahidis, T., Ainali, C., Dafou, D., Panteris, E., …Mosialos, G. (2020). The Tumor Suppressor CYLD Inhibits Mammary Epithelial to Mesenchymal Transition by the Coordinated Inhibition of YAP/TAZ and TGFβ Signaling. Cancers, 12(8), 2047. https://doi.org/10.3390/cancers12082047

Downregulation of the cylindromatosis (CYLD) tumor suppressor has been associated with breast cancer development and progression. Here, we report a critical role for CYLD in maintaining the phenotype of mammary epithelial cells in vitro and in vivo.... Read More about The Tumor Suppressor CYLD Inhibits Mammary Epithelial to Mesenchymal Transition by the Coordinated Inhibition of YAP/TAZ and TGFβ Signaling.