All Outputs (5)

Sialic Acid within the Glycosylphosphatidylinositol Anchor Targets the Cellular Prion Protein to Synapses (2016)
Journal Article
Bate, C., Nolan, W., McHale-Owen, H., & Williams, A. (2016). Sialic Acid within the Glycosylphosphatidylinositol Anchor Targets the Cellular Prion Protein to Synapses. Journal of Biological Chemistry, 291(33), 17093-101. https://doi.org/10.1074/jbc.M116.731117

Although the cellular prion protein (PrPC) is concentrated at synapses, the factors that target PrPC to synapses are not understood. Here we demonstrate that exogenous PrPC was rapidly targeted to synapses in recipient neurons derived from Prnp knock... Read More about Sialic Acid within the Glycosylphosphatidylinositol Anchor Targets the Cellular Prion Protein to Synapses.

Does the tail wag the dog? How the structure of a glycosylphosphatidylinositol anchor affects prion formation (2016)
Journal Article
Bate, C., Nolan, W., & Williams, A. (2016). Does the tail wag the dog? How the structure of a glycosylphosphatidylinositol anchor affects prion formation. Prion, 10(2), 127-30. https://doi.org/10.1080/19336896.2016.1148237

Glimepiride protects neurons against amyloid-beta-induced synapse damage (2016)
Journal Article
Osborne, C., West, E., Nolan, W., McHale-Owen, H., Williams, A., & Bate, C. (2016). Glimepiride protects neurons against amyloid-beta-induced synapse damage. Neuropharmacology, 101, 225-236. https://doi.org/10.1016/j.neuropharm.2015.09.030

An in vitro model for synaptic loss in neurodegenerative diseases suggests a neuroprotective role for valproic acid via inhibition of cPLA(2) dependent signalling (2016)
Journal Article
Williams, R. S. B., & Bate, C. (2016). An in vitro model for synaptic loss in neurodegenerative diseases suggests a neuroprotective role for valproic acid via inhibition of cPLA(2) dependent signalling. Neuropharmacology, 101, 566-575. https://doi.org/10.1016/j.neuropharm.2015.06.013

Many neurodegenerative diseases present the loss of synapses as a common pathological feature. Here we have employed an in vitro model for synaptic loss to investigate the molecular mechanism of a therapeutic treatment, valproic acid (VPA). We show t... Read More about An in vitro model for synaptic loss in neurodegenerative diseases suggests a neuroprotective role for valproic acid via inhibition of cPLA(2) dependent signalling.

Sialic Acid on the Glycosylphosphatidylinositol Anchor Regulates PrP-mediated Cell Signaling and Prion Formation (2016)
Journal Article
Bate, C., Nolan, W., McHale-Owen, H., & Williams, A. (2016). Sialic Acid on the Glycosylphosphatidylinositol Anchor Regulates PrP-mediated Cell Signaling and Prion Formation. Journal of Biological Chemistry, 291(33), 17093-17101. https://doi.org/10.1074/jbc.M116.731117

The prion diseases occur following the conversion of the cellular prion protein (PrPC) into disease-related isoforms (PrPSc). In this study, the role of the glycosylphosphatidylinositol (GPI) anchor attached to PrPC in prion formation was examined us... Read More about Sialic Acid on the Glycosylphosphatidylinositol Anchor Regulates PrP-mediated Cell Signaling and Prion Formation.