The efficacy of alcelaphine herpesvirus-1 (AlHV-1) immunization with the adjuvants Emulsigen® and the monomeric TLR5 ligand FliC in zebu cattle against AlHV-1 malignant catarrhal fever induced by experimental virus challenge
(2016)
Journal Article
Lankester, F., Lugelo, A., Werling, D., Mnyambwa, N., Keyyu, J., Kazwala, R., …Haig, D. (2016). The efficacy of alcelaphine herpesvirus-1 (AlHV-1) immunization with the adjuvants Emulsigen® and the monomeric TLR5 ligand FliC in zebu cattle against AlHV-1 malignant catarrhal fever induced by experimental virus challenge. Veterinary Microbiology, 195, 144-153. https://doi.org/10.1016/j.vetmic.2016.09.019
All Outputs (124)
Identification of Theileria lestoquardi Antigens Recognized by CD8+ T Cells (2016)
Journal Article
Goh, S., Ngugi, D., Lizundia, R., Hostettler, I., Woods, K., Ballingall, K., …Werling, D. (2016). Identification of Theileria lestoquardi Antigens Recognized by CD8+ T Cells. PLoS ONE, 11(9), e0162571. https://doi.org/10.1371/journal.pone.0162571
Oral application of freeze-dried yeast particles expressing the PCV2b Cap protein on their surface induce protection to subsequent PCV2b challenge in vivo (2015)
Journal Article
Patterson, R., Eley, T. S., Browne, C., Martineau, H. M., & Werling, D. (2015). Oral application of freeze-dried yeast particles expressing the PCV2b Cap protein on their surface induce protection to subsequent PCV2b challenge in vivo. Vaccine, 33(46), 6199-205. https://doi.org/10.1016/j.vaccine.2015.10.003Porcine circovirus type 2 (PCV2) is now endemic in every major pig producing country, causing PCV-associated disease (PCVAD), linked with large scale economic losses. Current vaccination strategies are based on the capsid protein of the virus and are... Read More about Oral application of freeze-dried yeast particles expressing the PCV2b Cap protein on their surface induce protection to subsequent PCV2b challenge in vivo.
Combining Genome Wide Association Studies and Differential Gene Expression Data Analyses Identifies Candidate Genes Affecting Mastitis Caused by Two Different Pathogens in the Dairy Cow (2015)
Journal Article
Chen, X., Cheng, Z. R., Zhang, S., Werling, D., & Wathes, D. C. (2015). Combining Genome Wide Association Studies and Differential Gene Expression Data Analyses Identifies Candidate Genes Affecting Mastitis Caused by Two Different Pathogens in the Dairy Cow. Open Journal of Animal Sciences, 5(4), 358-393. https://doi.org/10.4236/ojas.2015.54040Mastitis is a costly disease which hampers the dairy industry. Inflammation of the mammary gland is commonly caused by bacterial infection, mainly Escherichia coli, Streptococcus uberis and Staphylococcus aureus. As more bacteria become multi-drug re... Read More about Combining Genome Wide Association Studies and Differential Gene Expression Data Analyses Identifies Candidate Genes Affecting Mastitis Caused by Two Different Pathogens in the Dairy Cow.
Exposure to environmental stressors result in increased viral load and further reduction of production parameters in pigs experimentally infected with PCV2b (2015)
Journal Article
Patterson, R., Nevel, M., Diaz, A. V., Martineau, H. M., Demmers, T. G. M., Browne, C., …Werling, D. (2015). Exposure to environmental stressors result in increased viral load and further reduction of production parameters in pigs experimentally infected with PCV2b. Veterinary Microbiology, 177(3-4), 261-269. https://doi.org/10.1016/j.vetmic.2015.03.010Porcine circovirus type 2 (PCV2) has been identified as the essential, but not sole, underlying infectious component for PCV-associated diseases (PCVAD). Several co-factors have been suggested to convert an infection with PCV2 into the clinical signs... Read More about Exposure to environmental stressors result in increased viral load and further reduction of production parameters in pigs experimentally infected with PCV2b.
A Prospective, Randomized, Blinded, Placebo-Controlled Pilot Study on the Effect of Enterococcus faecium on Clinical Activity and Intestinal Gene Expression in Canine Food-Responsive Chronic Enteropathy (2015)
Journal Article
Schmitz, S., Glanemann, B., Garden, O. A., Brooks, H. W., Chang, Y. M., Werling, D., & Allenspach, K. (2015). A Prospective, Randomized, Blinded, Placebo-Controlled Pilot Study on the Effect of Enterococcus faecium on Clinical Activity and Intestinal Gene Expression in Canine Food-Responsive Chronic Enteropathy. Journal of Veterinary Internal Medicine, 29(2), 533-43. https://doi.org/10.1111/jvim.12563
Two TIR-like domain containing proteins in a newly emerging zoonotic Staphylococcus aureus strain sequence type 398 are potential virulence factors by impacting on the host innate immune response (2014)
Journal Article
Patterson, N. J., Günther, J., Gibson, A. J., Offord, V., Coffey, T. J., Splitter, G., …Werling, D. (2014). Two TIR-like domain containing proteins in a newly emerging zoonotic Staphylococcus aureus strain sequence type 398 are potential virulence factors by impacting on the host innate immune response. Frontiers in Microbiology, 5(662), https://doi.org/10.3389/fmicb.2014.00662Staphylococcus aureus, sequence type (ST) 398, is an emerging pathogen and the leading cause of livestock-associated methicillin-resistant S. aureus infections in Europe and North America. This strain is characterized by high promiscuity in terms of... Read More about Two TIR-like domain containing proteins in a newly emerging zoonotic Staphylococcus aureus strain sequence type 398 are potential virulence factors by impacting on the host innate immune response.
Association between nucleotide oligomerisation domain two(Nod2) gene polymorphisms and canine inflammatory bowel disease (2014)
Journal Article
Kathrani, A., Lee, H., White, C., Catchpole, B., Murphy, A. M., German, A., …Allenspach, K. (2014). Association between nucleotide oligomerisation domain two(Nod2) gene polymorphisms and canine inflammatory bowel disease. Veterinary Immunology and Immunopathology, 161(1-2), 32-41. https://doi.org/10.1016/j.vetimm.2014.06.003The most important genetic associations that have been implicated to play a role in the etiology of Crohn's disease (CD) in humans are single nucleotide polymorphisms (SNPs) in nucleotide oligomerisation domain 2 (NOD2). The aim of this study was to... Read More about Association between nucleotide oligomerisation domain two(Nod2) gene polymorphisms and canine inflammatory bowel disease.
Global Gene Expression Profiling of Myeloid Immune Cell Subsets in Response to In Vitro Challenge with Porcine Circovirus 2b (2014)
Journal Article
Mavrommatis, B., Offord, V., Patterson, R., Watson, M., Kanellos, T., Steinbach, F., …Werling, D. (2014). Global Gene Expression Profiling of Myeloid Immune Cell Subsets in Response to In Vitro Challenge with Porcine Circovirus 2b. PLoS ONE, 9(3), e91081. https://doi.org/10.1371/journal.pone.0091081Compelling evidence suggests that the early interaction between porcine circovirus 2 (PCV-2) and the innate immune system is the key event in the pathogenesis of Post-Weaning Multisystemic Wasting Syndrome (PMWS). Furthermore, PCV2 has been detected... Read More about Global Gene Expression Profiling of Myeloid Immune Cell Subsets in Response to In Vitro Challenge with Porcine Circovirus 2b.
Yeast-surface expressed BVDV E2 protein induces a Th1/Th2 response in naïve T cells (2012)
Journal Article
Patterson, R., Nerren, J., Kogut, M., Court, P., Villarreal-Ramos, B., Seyfert, H. M., …Werling, D. (2012). Yeast-surface expressed BVDV E2 protein induces a Th1/Th2 response in naïve T cells. Developmental and Comparative Immunology, 37(1), 107-114. https://doi.org/10.1016/j.dci.2011.10.009Yeast species such as Saccharomyces cerevisiae are known to be potent activators of the immune system. S. cerevisiae activates the innate immune system by engaging pattern recognition receptors such as toll like receptor 2 (TLR2) and dectin-1. In the... Read More about Yeast-surface expressed BVDV E2 protein induces a Th1/Th2 response in naïve T cells.
Assessment and quantification of post-weaning multi-systemic wasting syndrome severity at farm level
Journal Article
Alarcon, P., Velasova, M., Werling, D., Staerk, K. D. C., Chang, Y. M., Nevel, M., …Wieland, B. Assessment and quantification of post-weaning multi-systemic wasting syndrome severity at farm level. Preventive Veterinary Medicine, 98(1), 19-28. https://doi.org/10.1016/j.prevetmed.2010.09.022
MUTATIONAL ANALYSIS OF THE TLR5 GENE IN BOXER DOGS WITH INFLAMMATORY BOWEL DISEASE REVEALS NOVEL POLYMORPHISM IN THE LEUCINE RICH REPEAT DOMAIN
Journal Article
Kathrani, A., Werling, D., & Allenspach, K. MUTATIONAL ANALYSIS OF THE TLR5 GENE IN BOXER DOGS WITH INFLAMMATORY BOWEL DISEASE REVEALS NOVEL POLYMORPHISM IN THE LEUCINE RICH REPEAT DOMAIN. Journal of Veterinary Internal Medicine, 25(3), 696-696
TOLL-LIKE RECEPTOR 5 MUTATIONS IN GERMAN SHEPHERD DOGS ARE HYPER-RESPONSIVE TO STIMULATION WITH FLAGELLIN
Journal Article
Allenspach, K., Kathrani, A., House, A. K., Holder, A. L., Catchpole, B., & Werling, D. TOLL-LIKE RECEPTOR 5 MUTATIONS IN GERMAN SHEPHERD DOGS ARE HYPER-RESPONSIVE TO STIMULATION WITH FLAGELLIN. Journal of Veterinary Internal Medicine, 25(3), 688-688
Calcium influx, a new potential therapeutic target in the control of neutrophil-dependent inflammatory diseases in bovines
Journal Article
Burgos, R. A., Conejeros, I., Hidalgo, M. A., Werling, D., & Hermosilla, C. Calcium influx, a new potential therapeutic target in the control of neutrophil-dependent inflammatory diseases in bovines. Veterinary Immunology and Immunopathology, 143(1-2), 1-10. https://doi.org/10.1016/j.vetimm.2011.05.037
Therapeutic targeting of the innate immune system in domestic animals
Journal Article
Coffey, T. J., & Werling, D. Therapeutic targeting of the innate immune system in domestic animals. Cell and Tissue Research, 343(1), 251-261. https://doi.org/10.1007/s00441-010-1054-9
Induction of reactive oxygen species in bovine neutrophils to CD11b, but not dectin-1-dependent
Journal Article
Conejeros, I., Patterson, R., Burgos, R. A., Hermosilla, C., & Werling, D. Induction of reactive oxygen species in bovine neutrophils to CD11b, but not dectin-1-dependent. Veterinary Immunology and Immunopathology, 139(2-4), 308-312. https://doi.org/10.1016/j.vetimm.2010.10.021
POLYMORPHISMS IN THE TOLL LIKE RECEPTOR 5 GENE ARE SIGNIFICANTLY ASSOCIATED WITH INFLAMMATORY BOWEL DISEASE IN A POPULATION CONSISTING OF 38 DIFFERENT DOG BREEDS
Journal Article
Kathrani, A., House, A. K., Werling, D., Catchpole, B., Murphy, A. M., & Allenspach, K. POLYMORPHISMS IN THE TOLL LIKE RECEPTOR 5 GENE ARE SIGNIFICANTLY ASSOCIATED WITH INFLAMMATORY BOWEL DISEASE IN A POPULATION CONSISTING OF 38 DIFFERENT DOG BREEDS. Journal of Veterinary Internal Medicine, 25(3), 696-696
Canine breeds at high risk of developing inflammatory bowel disease in the south-eastern UK
Journal Article
Kathrani, A., Werling, D., & Allenspach, K. Canine breeds at high risk of developing inflammatory bowel disease in the south-eastern UK. Veterinary Record, 169(24), E-pub. https://doi.org/10.1136/vr.d5380
CD11c(+) Cells are Significantly Decreased in the Duodenum, Ileum and Colon of Dogs with Inflammatory Bowel Disease
Journal Article
Kathrani, A., Schmitz, S., Priestnall, S. L., Smith, K. C., Werling, D., Garden, O. A., & Allenspach, K. CD11c(+) Cells are Significantly Decreased in the Duodenum, Ileum and Colon of Dogs with Inflammatory Bowel Disease. Journal of Comparative Pathology, 145(4), 359-366. https://doi.org/10.1016/j.jcpa.2011.03.010
Bovine Viral Diarrhea Virus Strain- and Cell Type-Specific Inhibition of Type I Interferon Pathways
Journal Article
Gibson, A. J., Larsson, J., Bateman, M., Brownlie, J., & Werling, D. Bovine Viral Diarrhea Virus Strain- and Cell Type-Specific Inhibition of Type I Interferon Pathways. Journal of Virology, 85(7), 3695-3697. https://doi.org/10.1128/jvi.02626-10