OUTCOME MEASURES IN THE MDX MOUSE
Journal Article
Wells, D. J. OUTCOME MEASURES IN THE MDX MOUSE. Neuromuscular Disorders, 21, S5-S5
All Outputs (80)
ASSESSING THE THERAPEUTIC POTENTIAL OF LARGE IN A NEW MOUSE MODEL OF DYSTROGLYCANOPATHY
Journal Article
Whitmore, C., Ackroyd, M. R., Muses, S., Ashraf, A., Muntoni, F., Brown, S. C., & Wells, D. J. ASSESSING THE THERAPEUTIC POTENTIAL OF LARGE IN A NEW MOUSE MODEL OF DYSTROGLYCANOPATHY. Neuromuscular Disorders, 21(9-10), 665-665. https://doi.org/10.1016/j.nmd.2011.06.838
Investigation of a transgenic mouse model of familial dilated cardiomyopathy
Journal Article
Song, W., Dyer, E., Stuckey, D., Leung, M., Memo, M., Mansfield, C., …Marston, S. Investigation of a transgenic mouse model of familial dilated cardiomyopathy. Journal of Molecular and Cellular Cardiology, 49(3), 380-389. https://doi.org/10.1016/j.yjmcc.2010.05.009
MDX MICE SHOW CHANGES IN MUSCLE FIBER PROFILE NUMBER WITH AGE
Journal Article
Terry, R. L., Hasan, N., & Wells, D. J. MDX MICE SHOW CHANGES IN MUSCLE FIBER PROFILE NUMBER WITH AGE. Human Gene Therapy, 21(4), 516-516
Overexpression of heat shock protein 27 reduces cortical damage after cerebral ischemia
Journal Article
Van Der Weerd, L., Tariq Akbar, M., Aron Badin, R., Valentim, L. M., Thomas, D. L., Wells, D. J., …De Belleroche, J. S. Overexpression of heat shock protein 27 reduces cortical damage after cerebral ischemia. https://doi.org/10.1038/jcbfm.2009.249
Electroporation and ultrasound enhanced non-viral gene delivery in vitro and in vivo
Journal Article
Wells, D. J. Electroporation and ultrasound enhanced non-viral gene delivery in vitro and in vivo. Cell Biology and Toxicology, 26(1), 21-28. https://doi.org/10.1007/s10565-009-9144-8
MAKING SENSE IN DUCHENNE MUSCULAR DYSTROPHY
Journal Article
Wells, D. J. MAKING SENSE IN DUCHENNE MUSCULAR DYSTROPHY. Human Gene Therapy, 21(4), 495-495
Microbubble stability is a major determinant of the efficiency of ultrasound and microbubble mediated in vivo gene transfer
Journal Article
Alter, J., Sennoga, C. A., Lopes, D., Eckserley, R. J., & Wells, D. J. Microbubble stability is a major determinant of the efficiency of ultrasound and microbubble mediated in vivo gene transfer. Ultrasound in Medicine and Biology, 35(6), 976-84. https://doi.org/10.1016/j.ultrasmedbio.2008.12.015
Mice that overexpresses human heat shock protein 27 have increased renal injury following ischemia reperfusion
Journal Article
Chen, S. W. C., Kim, M., Kim, M., Song, J. H., Park, S. W., Wells, D. J., …Lee, H. T. Mice that overexpresses human heat shock protein 27 have increased renal injury following ischemia reperfusion. Kidney International, 75(5), 499-510. https://doi.org/10.1038/ki.2008.572
Heat shock protein 27 overexpression mitigates cytokine-induced islet apoptosis and streptozotocin-induced diabetes
Journal Article
Dai, T., Patel-Chamberlin, M., Natarajan, R., Todorov, I., Ma, J., LaPage, J., …Adler, S. G. Heat shock protein 27 overexpression mitigates cytokine-induced islet apoptosis and streptozotocin-induced diabetes. Endocrinology, 150(7), 3031-9. https://doi.org/10.1210/en.2008-0732
In silico characterisation and chromosomal localisation of human RRH (peropsin) – implications for opsin evolution
Journal Article
Bellingham, J., Wells, D. J., & Foster, R. G. In silico characterisation and chromosomal localisation of human RRH (peropsin) – implications for opsin evolution. BMC Genomics, 4(1), 3. https://doi.org/10.1186/1471-2164-4-3
Systemic MV Gene Therapy Close to Clinical Trials for Several Neuromuscular Diseases
Journal Article
Wells, D. J. (in press). Systemic MV Gene Therapy Close to Clinical Trials for Several Neuromuscular Diseases. Molecular Therapy, 25(4), 834-835. https://doi.org/10.1016/j.ymthe.2017.03.006
GENERATION OF THREE-DIMENSIONAL HUMAN ARTIFICIAL SKELETAL MUSCLE TISSUE FROM IPS CELLS ENABLES COMPLEX DISEASE MODELLING FOR MUSCULAR DYSTROPHY
Journal Article
Maffioletti, S. M., Sarcar, S., Henderson, A., Mannhardt, I., Pinton, L., Moyle, L. A., …Tedesco, F. S. GENERATION OF THREE-DIMENSIONAL HUMAN ARTIFICIAL SKELETAL MUSCLE TISSUE FROM IPS CELLS ENABLES COMPLEX DISEASE MODELLING FOR MUSCULAR DYSTROPHY. Human Gene Therapy, 28(12), A2-A2
Designing translationally relevant preclinical studies of new therapeutics
Journal Article
Wells, D. J. Designing translationally relevant preclinical studies of new therapeutics. Experimental Physiology, 102(6), 616. https://doi.org/10.1113/EP086296
Codon optimisation of microdystrophin improves expression and physiological outcome in dystrophic mdx mice following AAV2/8 gene transfer
Journal Article
Foster, H., Sharp, P., Trollet, C., Athanasopoulos, T., Graham, I., Foster, K., …Dickson, G. Codon optimisation of microdystrophin improves expression and physiological outcome in dystrophic mdx mice following AAV2/8 gene transfer. Molecular Therapy, 16(11), 1825-32. https://doi.org/10.1038/mt.2008.186
Extracellular Release of the Atheroprotective Heat Shock Protein 27 Is Mediated by Estrogen and Competitively Inhibits acLDL Binding to Scavenger Receptor-A
Journal Article
Rayner, K., Chen, Y., McNulty, M., Simard, T., Zhao, X., Wells, D. J., …O'Brien, E. R. Extracellular Release of the Atheroprotective Heat Shock Protein 27 Is Mediated by Estrogen and Competitively Inhibits acLDL Binding to Scavenger Receptor-A. Circulation Research, 103(2), 133-141. https://doi.org/10.1161/CIRCRESAHA.108.172155
Protective effects of heat shock protein 27 in a model of ALS occur in the early stages of disease progression
Journal Article
Sharp, P. A., Akbar, T., Bouri, S., Senda, A., Joshi, K., Chen, H. J., …De Belleroche, J. Protective effects of heat shock protein 27 in a model of ALS occur in the early stages of disease progression. Neurobiology of Disease, 30(1), 42-55. https://doi.org/10.1016/j.nbd.2007.12.002
Three-Dimensional Human iPSC-Derived Artificial Skeletal Muscles Model Muscular Dystrophies and Enable Multilineage Tissue Engineering
Journal Article
Maffioletti, S. M., Sarcar, S., Henderson, A. B. H., Mannhardt, I., Pinton, L., Moyle, L. A., …Tedesco, F. S. (in press). Three-Dimensional Human iPSC-Derived Artificial Skeletal Muscles Model Muscular Dystrophies and Enable Multilineage Tissue Engineering. Cell Reports, 23(3), 899-908. https://doi.org/10.1016/j.celrep.2018.03.091
Characterisation of the pathogenic effects of the in vivo expression of an ALS-linked mutation in D-amino acid oxidase: Phenotype and loss of spinal cord motor neurons
Journal Article
Kondori, N. R., Paul, P., Robbins, J. P., Liu, K., Hildyard, J. C. W., Wells, D. J., & De Belleroche, J. S. (in press). Characterisation of the pathogenic effects of the in vivo expression of an ALS-linked mutation in D-amino acid oxidase: Phenotype and loss of spinal cord motor neurons. PLoS ONE, 12, e0188912. https://doi.org/10.1371/journal.pone.0188912Amyotrophic lateral sclerosis (ALS) is the most common adult-onset neuromuscular disorder characterised by selective loss of motor neurons leading to fatal paralysis. Current therapeutic approaches are limited in their effectiveness. Substantial adva... Read More about Characterisation of the pathogenic effects of the in vivo expression of an ALS-linked mutation in D-amino acid oxidase: Phenotype and loss of spinal cord motor neurons.
Muscle moment arms and sensitivity analysis of a mouse hindlimb musculoskeletal model
Journal Article
Charles, J. P., Cappellari, O., Spence, A. J., Wells, D. J., & Hutchinson, J. R. (in press). Muscle moment arms and sensitivity analysis of a mouse hindlimb musculoskeletal model. Journal of Anatomy, 229(4), 514-535. https://doi.org/10.1111/joa.12461