Musculoskeletal Geometry, Muscle Architecture and Functional Specialisations of the Mouse Hindlimb

Charles, J P; Cappellari, O; Spence, A J; Hutchinson, J R; Wells, D J

doi:10.1371/journal.pone.0147669

All Outputs (5)

Growth differentiation factor-15 is associated with muscle mass in chronic obstructive pulmonary disease and promotes muscle wasting in vivo (2016)
Journal Article
Patel, M. S., Lee, J., Baz, M., Wells, C. E., Bloch, S., Lewis, A., …Kemp, P. R. (2016). Growth differentiation factor-15 is associated with muscle mass in chronic obstructive pulmonary disease and promotes muscle wasting in vivo. Journal of Cachexia, Sarcopenia and Muscle, 7(4), 436-448. https://doi.org/10.1002/jcsm.12096

Olfactory variation in mouse husbandry and its implications for refinement and standardisation: UK survey of non-animal scents (2016)
Journal Article
Lopez-Salesansky, N., Mazlan, N. H., Whitfield, L. E., Wells, D. J., & Burn, C. C. (2016). Olfactory variation in mouse husbandry and its implications for refinement and standardisation: UK survey of non-animal scents. Laboratory Animals, 50(4), 286-295. https://doi.org/10.1177/0023677215614296

With their highly sensitive olfactory system, the behaviour and physiology of mice are not only influenced by the scents of conspecifics and other species, but also by many other chemicals in the environment. The constraints of laboratory housing lim... Read More about Olfactory variation in mouse husbandry and its implications for refinement and standardisation: UK survey of non-animal scents.

Transgenic Rescue of the LARGEmyd Mouse: A LARGE Therapeutic Window? (2016)
Journal Article
Hildyard, J. C. W., Lacey, E., Booler, H., Hopkinson, M., Wells, D. J., & Brown, S. C. (2016). Transgenic Rescue of the LARGEmyd Mouse: A LARGE Therapeutic Window?. PLoS ONE, 11(7), e0159853. https://doi.org/10.1371/journal.pone.0159853

LARGE is a glycosyltransferase involved in glycosylation of α-dystroglycan (α-DG). Absence of this protein in the LARGEmyd mouse results in α-DG hypoglycosylation, and is associated with central nervous system abnormalities and progressive muscular d... Read More about Transgenic Rescue of the LARGEmyd Mouse: A LARGE Therapeutic Window?.

Investigating synthetic oligonucleotide targeting of miR31 in Duchenne muscular dystrophy (2016)
Journal Article
Hildyard, J. C. W., & Wells, D. J. (2016). Investigating synthetic oligonucleotide targeting of miR31 in Duchenne muscular dystrophy. https://doi.org/10.1371/currents.md.99d88e72634387639707601b237467d7

Musculoskeletal Geometry, Muscle Architecture and Functional Specialisations of the Mouse Hindlimb (2016)
Journal Article
Charles, J. P., Cappellari, O., Spence, A. J., Hutchinson, J. R., & Wells, D. J. (2016). Musculoskeletal Geometry, Muscle Architecture and Functional Specialisations of the Mouse Hindlimb. PLoS ONE, 11(4), https://doi.org/10.1371/journal.pone.0147669

Mice are one of the most commonly used laboratory animals, with an extensive array of disease models in existence, including for many neuromuscular diseases. The hindlimb is of particular interest due to several close muscle analogues/homologues to h... Read More about Musculoskeletal Geometry, Muscle Architecture and Functional Specialisations of the Mouse Hindlimb.