All Outputs (4)

The PfRCR complex bridges malaria parasite and erythrocyte during invasion (2023)
Journal Article
Farrell, B., Alam, N., Hart, M. N., Jamwal, A., Ragotte, R. J., Walters-Morgan, H., …Higgins, M. K. (2023). The PfRCR complex bridges malaria parasite and erythrocyte during invasion. Nature, https://doi.org/10.1038/s41586-023-06856-1

The symptoms of malaria occur during the blood stage of infection, when parasites invade and replicate within human erythrocytes. The PfPCRCR complex1, containing PfRH5 (refs. 2,3), PfCyRPA, PfRIPR, PfCSS and PfPTRAMP, is essential for erythrocyte in... Read More about The PfRCR complex bridges malaria parasite and erythrocyte during invasion.

DNA-binding protein PfAP2-P regulates parasite pathogenesis during malaria parasite blood stages (2023)
Journal Article
Subudhi, A. K., Green, J. L., Satyam, R., Salunke, R. P., Lenz, T., Shuaib, M., …Pain, A. (2023). DNA-binding protein PfAP2-P regulates parasite pathogenesis during malaria parasite blood stages. Nature Microbiology, 8(11), 2154-2169. https://doi.org/10.1038/s41564-023-01497-6

Malaria-associated pathogenesis such as parasite invasion, egress, host cell remodelling and antigenic variation requires concerted action by many proteins, but the molecular regulation is poorly understood. Here we have characterized an essential Pl... Read More about DNA-binding protein PfAP2-P regulates parasite pathogenesis during malaria parasite blood stages.

Sequential roles for red blood cell binding proteins enable phased commitment to invasion for malaria parasites (2023)
Journal Article
Hart, M. N., Mohring, F., DonVito, S. M., Thomas, J. A., Muller-Sienerth, N., Wright, G. J., …Moon, R. W. (in press). Sequential roles for red blood cell binding proteins enable phased commitment to invasion for malaria parasites. Nature Communications, 14(1), 4619. https://doi.org/10.1038/s41467-023-40357-z

Invasion of red blood cells (RBCs) by Plasmodium merozoites is critical to their continued survival within the host. Two major protein families, the Duffy binding-like proteins (DBPs/EBAs) and the reticulocyte binding like proteins (RBLs/RHs) have be... Read More about Sequential roles for red blood cell binding proteins enable phased commitment to invasion for malaria parasites.

Characterisation of the bovine C-type lectin receptor Mincle and potential evidence for an endogenous ligand (2023)
Journal Article
Holder, A., Kolakowski, J., Rosentreter, C., Knuepfer, E., Jegouzo, S., Rosenwasser, O., …Werling, D. (2023). Characterisation of the bovine C-type lectin receptor Mincle and potential evidence for an endogenous ligand. Frontiers in Immunology, 14, https://doi.org/10.3389/fimmu.2023.1189587

Innate immune receptors that form complexes with secondary receptors, activating multiple signalling pathways, modulate cellular activation and play essential roles in regulating homeostasis and immunity. We have previously identified a variety of bo... Read More about Characterisation of the bovine C-type lectin receptor Mincle and potential evidence for an endogenous ligand.