Stable Sulforaphane Targets the Early Stages of Osteoclast Formation to Engender a Lasting Functional Blockade of Osteoclastogenesis

Louka, Polymnia; Orriss, Isabel R.; Pitsillides, Andrew A.

doi:10.3390/cells13020165

All Outputs (2)

Pathological calcification in canine tendon-derived cells is modulated by extracellular ATP (2024)
Journal Article
Zamboulis, D. E., Marr, N., Moustafa, A., Meeson, R., Orriss, I., & Thorpe, C. (in press). Pathological calcification in canine tendon-derived cells is modulated by extracellular ATP. Veterinary Research Communications, https://doi.org/10.1007/s11259-024-10331-1

Stable Sulforaphane Targets the Early Stages of Osteoclast Formation to Engender a Lasting Functional Blockade of Osteoclastogenesis (2024)
Journal Article
Louka, P., Orriss, I. R., & Pitsillides, A. A. (2024). Stable Sulforaphane Targets the Early Stages of Osteoclast Formation to Engender a Lasting Functional Blockade of Osteoclastogenesis. Cells, 13(2), https://doi.org/10.3390/cells13020165

Sulforaphane, the native but unstable form of SFX-01, is an antioxidant that activates the NRF2 and inhibits the NF-KB pathways to achieve its actions. Resolving the mechanism(s) by which SFX-01 serves to control the various osteoclastogenic stages m... Read More about Stable Sulforaphane Targets the Early Stages of Osteoclast Formation to Engender a Lasting Functional Blockade of Osteoclastogenesis.