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The translocator protein (TSPO) is prodromal to mitophagy loss in neurotoxicity (2021)
Journal Article
Frison, M., Faccenda, D., Abeti, R., Rigon, M., Strobbe, D., England-Rendon, B., …Campanella, M. (2021). The translocator protein (TSPO) is prodromal to mitophagy loss in neurotoxicity. Molecular Psychiatry, 26(7), 2721-2739. https://doi.org/10.1038/s41380-021-01050-z

Dysfunctional mitochondria characterise Parkinson's Disease (PD). Uncovering etiological molecules, which harm the homeostasis of mitochondria in response to pathological cues, is therefore pivotal to inform early diagnosis and therapy in the conditi... Read More about The translocator protein (TSPO) is prodromal to mitophagy loss in neurotoxicity.

Pharmacological advances in mitochondrial therapy (2021)
Journal Article
Singh, A., Faccenda, D., & Campanella, M. (2021). Pharmacological advances in mitochondrial therapy. EBioMedicine, 65, https://doi.org/10.1016/j.ebiom.2021.103244

Mitochondria play a vital role in cellular metabolism and are central mediator of intracellular signalling, cell differentiation, morphogenesis and demise. An increasingly higher number of pathologies is linked with mitochondrial dysfunction, which c... Read More about Pharmacological advances in mitochondrial therapy.

Mitochondria form cholesterol-rich contact sites with the nucleus during retrograde response (2020)
Journal Article
Desai, R., East, D. A., Hardy, L., Crosby, J., Faccenda, D., Alvarex, M. S., …Campanella, M. (2020). Mitochondria form cholesterol-rich contact sites with the nucleus during retrograde response. Science Advances, https://doi.org/10.1101/445411

Cholesterol metabolism is pivotal to cellular homeostasis, hormones production, and membranes composition. Its dysregulation associates with malignant reprogramming and therapy resistance. Cholesterol is trafficked into the mitochondria for steroidog... Read More about Mitochondria form cholesterol-rich contact sites with the nucleus during retrograde response.

Mitochondria form contact sites with the nucleus to couple pro-survival retrograde response (2020)
Journal Article
Desai, R., East, D. A., Hardy, L., Crosby, J., Rigon, M., Faccenda, D., …Campanella, M. (in press). Mitochondria form contact sites with the nucleus to couple pro-survival retrograde response. Science Advances, https://doi.org/10.1101/445411

Mitochondria drive cellular adaptation to stress by retro-communicating with the nucleus. This process is known as Mitochondrial Retrograde Response (MRR) and is induced by mitochondrial dysfunctions. MRR results in the nuclear stabilization of pro-s... Read More about Mitochondria form contact sites with the nucleus to couple pro-survival retrograde response.

The ATPase Inhibitory Factor 1 (IF1) regulates the expression of the mitochondrial Ca2+ uniporter (MCU) via the AMPK/CREB pathway (2020)
Journal Article
Faccenda, D., Gorini, G., Jones, A., Thornton, C., Baracca, A., Solaini, G., & Campanella, M. (2020). The ATPase Inhibitory Factor 1 (IF1) regulates the expression of the mitochondrial Ca2+ uniporter (MCU) via the AMPK/CREB pathway

•IF1 regulates MCU-dependent mitochondrial Ca2+ uptake. •IF1 loss induces MCU upregulation through activation of the AMPK/CREB pathway. •OMA1 depletion restores physiological MCU levels and mitochondrial Ca2+ entry.

Mitochondria Regulate Inflammatory Paracrine Signalling in Neurodegeneration. (2020)
Journal Article
Faccenda, D., & Campanella, M. (2020). Mitochondria Regulate Inflammatory Paracrine Signalling in Neurodegeneration. Journal of Neuroimmune Pharmacology,

Mitochondrial dysfunction occurs in most neurodegenerative diseases, contributing to both their onset and progression. A recent breakthrough unveiled that propagation of the inflammatory response and subsequent neuronal injury are also mediated extra... Read More about Mitochondria Regulate Inflammatory Paracrine Signalling in Neurodegeneration..

Species-specific consequences of an E40K missense mutation in superoxide dismutase 1 (SOD1) (2019)
Journal Article
Draper, A. C. E., Wilson, Z., Maile, C. A., Faccenda, D., Campanella, M., & Piercy, R. J. (2019). Species-specific consequences of an E40K missense mutation in superoxide dismutase 1 (SOD1). FASEB Journal, https://doi.org/10.1096/fj.201901455R

A glutamic acid to lysine (E40K) residue substitution in superoxide dismutase 1 (SOD1) is associated with canine degenerative myelopathy: the only naturally occurring large animal model of amyotrophic lateral sclerosis (ALS). The E40 residue is highl... Read More about Species-specific consequences of an E40K missense mutation in superoxide dismutase 1 (SOD1).

Targeting Drp1 and mitochondrial fission for therapeutic immune modulation (2019)
Journal Article
Simula, L., Campanella, M., & Campello, S. (2019). Targeting Drp1 and mitochondrial fission for therapeutic immune modulation. Pharmacological Research, 146, https://doi.org/10.1016/j.phrs.2019.104317

Mitochondria are dynamic organelles whose processes of fusion and fission are tightly regulated by specialized proteins, known as mitochondria-shaping proteins. Among them, Drp1 is the main pro-fission protein and its activity is tightly regulated to... Read More about Targeting Drp1 and mitochondrial fission for therapeutic immune modulation.

Exploring mitochondrial cholesterol (mChol) signalling for therapeutic intervention in neurological conditions (2019)
Journal Article
Desai, R., & Campanella, M. (2019). Exploring mitochondrial cholesterol (mChol) signalling for therapeutic intervention in neurological conditions. British Journal of Pharmacology, https://doi.org/10.1111/bph.14697

The pharmacological targeting of cholesterol levels continues to draw interest due to the vast success of therapeutics such as statins in extending life expectancy by modifying the prognosis of diseases associated with the impairment of the lipid met... Read More about Exploring mitochondrial cholesterol (mChol) signalling for therapeutic intervention in neurological conditions.

Transglutaminase Type 2 Regulates ER-Mitochondria Contact Sites by Interacting with GRP75 (2018)
Journal Article
D'Eletto, M., Rossin, F., Occhigrossi, L., Farrace, M. G., Faccenda, D., Desai, R., …Piacentini, M. (2018). Transglutaminase Type 2 Regulates ER-Mitochondria Contact Sites by Interacting with GRP75. Cell Reports, 25(12), 3573-3581. https://doi.org/10.1016/j.celrep.2018.11.094

Transglutaminase type 2 (TG2) is a multifunctional enzyme that plays a key role in mitochondria homeostasis under stressful cellular conditions. TG2 interactome analysis reveals an enzyme interaction with GRP75 (glucose-regulated protein 75). GRP75 l... Read More about Transglutaminase Type 2 Regulates ER-Mitochondria Contact Sites by Interacting with GRP75.

Common Traits Spark the Mitophagy/Xenophagy Interplay (2018)
Journal Article
Singh, A., Kendall, S. L., & Campanella, M. (2018). Common Traits Spark the Mitophagy/Xenophagy Interplay. Frontiers in Physiology, 9, https://doi.org/10.3389/fphys.2018.01172

Selective autophagy contributes to the wellbeing of eukaryotic cells by recycling cellular components, disposing damaged organelles, and removing pathogens, amongst others. Both the quality control process of selective mitochondrial autophagy (Mitoph... Read More about Common Traits Spark the Mitophagy/Xenophagy Interplay.

HUWE1 E3 ligase promotes PINK1/PARKINindependent mitophagy by regulating AMBRA1 activation via IKKa (2018)
Journal Article
Di Rita, A., Peschiaroli, A., D'Acunzo, P., Strobbe, D., Hu, Z., Gruber, J., …Cecconi, F. (2018). HUWE1 E3 ligase promotes PINK1/PARKINindependent mitophagy by regulating AMBRA1 activation via IKKa. Nature Communications, 9(3755), https://doi.org/10.1038/s41467-018-05722-3

The selective removal of undesired or damaged mitochondria by autophagy, known as mitophagy, is crucial for cellular homoeostasis, and prevents tumour diffusion, neurodegeneration and ageing. The pro-autophagic molecule AMBRA1 (autophagy/beclin-1 reg... Read More about HUWE1 E3 ligase promotes PINK1/PARKINindependent mitophagy by regulating AMBRA1 activation via IKKa.

Reduction of the ATPase inhibitory factor 1 (IF1) leads to visual impairment in vertebrates (2018)
Journal Article
Martin-Jimenez, R., Faccenda, D., Allen, E., Reichel, H. B., Arcos, L., Ferraina, C., …Campanella, M. (2018). Reduction of the ATPase inhibitory factor 1 (IF1) leads to visual impairment in vertebrates. https://doi.org/10.1038/s41419-018-0578-x

In vertebrates, mitochondria are tightly preserved energy producing organelles, which sustain nervous system development and function. The understanding of proteins that regulate their homoeostasis in complex animals is therefore critical and doing s... Read More about Reduction of the ATPase inhibitory factor 1 (IF1) leads to visual impairment in vertebrates.

Reversible Keap1 inhibitors are preferential pharmacological tools to modulate cellular mitophagy (2017)
Journal Article
Georgakopoulos, N. D., Frison, M., Alvarez, M. S., Bertrand, H., Wells, G., & Campanella, M. (2017). Reversible Keap1 inhibitors are preferential pharmacological tools to modulate cellular mitophagy. https://doi.org/10.1038/s41598-017-07679-7

Mitophagy orchestrates the autophagic degradation of dysfunctional mitochondria preventing their pathological accumulation and contributing to cellular homeostasis. We previously identified a novel chemical tool (hereafter referred to as PMI), which... Read More about Reversible Keap1 inhibitors are preferential pharmacological tools to modulate cellular mitophagy.

A role for TSPO in mitochondrial Ca2+ homeostasis and redox stress signaling (2017)
Journal Article
Gatliff, J., East, D. A., Singh, A., Alvarez, M. S., Frison, M., Matic, I., …Campanella, M. (2017). A role for TSPO in mitochondrial Ca2+ homeostasis and redox stress signaling. https://doi.org/10.1038/cddis.2017.186

The 18?kDa translocator protein TSPO localizes on the outer mitochondrial membrane (OMM). Systematically overexpressed at sites of neuroinflammation it is adopted as a biomarker of brain conditions. TSPO inhibits the autophagic removal of mitochondri... Read More about A role for TSPO in mitochondrial Ca2+ homeostasis and redox stress signaling.

Control of Mitochondrial Remodeling by the ATPase Inhibitory Factor 1 Unveils a Pro-survival Relay via OPA1 (2017)
Journal Article
Faccenda, D., Nakamura, J., Gorini, G., Dhoot, G. K., Piacentini, M., Yoshida, M., & Campanella, M. (2017). Control of Mitochondrial Remodeling by the ATPase Inhibitory Factor 1 Unveils a Pro-survival Relay via OPA1. Cell Reports, https://doi.org/10.1016/j.celrep.2017.01.070

The ubiquitously expressed ATPase inhibitory factor 1 (IF1) is a mitochondrial protein that blocks the reversal of the F1Fo-ATPsynthase, preventing dissipation of cellular ATP and ischemic damage. IF1 suppresses programmed cell death, enhancing tumor... Read More about Control of Mitochondrial Remodeling by the ATPase Inhibitory Factor 1 Unveils a Pro-survival Relay via OPA1.