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All Outputs (16)

Challenges in developing a split drive targeting dsx for the genetic control of the invasive malaria vector Anopheles stephensi (2025)
Journal Article
Larrosa-Godall, M., Ang, J., Leftwich, P., Gonzalez, E., Shackleford, L., Nevard, K., Noad, R., Anderson, M., & Alphey, L. (2025). Challenges in developing a split drive targeting dsx for the genetic control of the invasive malaria vector Anopheles stephensi. Parasites and Vectors, 18(1), https://doi.org/10.1186/s13071-025-06688-0

BackgroundAnopheles stephensi is a competent malaria vector mainly present in southern Asia and the Arabian Peninsula. Since 2012, it has invaded several countries of eastern Africa, creating an emerging risk of urban transmission. Urgent efforts are... Read More about Challenges in developing a split drive targeting dsx for the genetic control of the invasive malaria vector Anopheles stephensi.

Intron-derived small RNAs for silencing viral RNAs in mosquito cells (2022)
Journal Article
Tng, P., Paladino, L., Anderson, M., Adelman, Z., Fragkoudis, R., Noad, R., & Alphey, L. (2022). Intron-derived small RNAs for silencing viral RNAs in mosquito cells. PLoS Neglected Tropical Diseases, 16(6), https://doi.org/10.1371/journal.pntd.0010548

Aedes aegypti and Ae. albopictus are the main vectors of mosquito-borne viruses of medical and veterinary significance. Many of these viruses have RNA genomes. Exogenously provided, e.g. transgene encoded, small RNAs could be used to inhibit virus re... Read More about Intron-derived small RNAs for silencing viral RNAs in mosquito cells.

Cas13b-dependent and Cas13b-independent RNA knockdown of viral sequences in mosquito cells following guide RNA expression (2020)
Journal Article
Tng, P. Y. L., Carabajal Paladino, L., Verkuijl, S. A. N., Purcell, J., Merits, A., Leftwich, P. T., Fragkoudis, R., Noad, R., & Alphey, L. (2020). Cas13b-dependent and Cas13b-independent RNA knockdown of viral sequences in mosquito cells following guide RNA expression. Communications Biology, 3(1), https://doi.org/10.1038/s42003-020-01142-6

Aedes aegypti and Aedes albopictus mosquitoes are vectors of the RNA viruses chikungunya (CHIKV) and dengue that currently have no specific therapeutic treatments. The
development of new methods to generate virus-refractory mosquitoes would be benef... Read More about Cas13b-dependent and Cas13b-independent RNA knockdown of viral sequences in mosquito cells following guide RNA expression.

UK vaccines network: Mapping priority pathogens of epidemic potential and vaccine pipeline developments (2019)
Journal Article
Noad, R. J., Simpson, K., Fooks, A. R., Hewson, R., Gilbert, S. C., Stevens, M. P., Hosie, M. J., Prior, J., Kinsey, A. M., Entrican, G., Simpson, A., Whitty, C. J. M., & Carroll, M. W. (2019). UK vaccines network: Mapping priority pathogens of epidemic potential and vaccine pipeline developments. Vaccine, 37(43), 6241-6247. https://doi.org/10.1016/j.vaccine.2019.09.009

During the 2013–2016 Ebola outbreak in West Africa an expert panel was established on the instructions of the UK Prime Minister to identify priority pathogens for outbreak diseases that had the potential to cause future epidemics. A total of 13 prior... Read More about UK vaccines network: Mapping priority pathogens of epidemic potential and vaccine pipeline developments.