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All Outputs (79)

Cognitive dysfunction in naturally occurring canine idiopathic epilepsy (2018)
Journal Article
Packer, R. M. A., McGreevy, P. D., Salvin, H. E., Valenzuela, M. J., Chaplin, C. M., & Volk, H. A. (2018). Cognitive dysfunction in naturally occurring canine idiopathic epilepsy. PLoS ONE, 13(2), e0192182. https://doi.org/10.1371/journal.pone.0192182

Globally, epilepsy is a common serious brain disorder. In addition to seizure activity, epilepsy is associated with cognitive impairments including static cognitive impairments present at onset, progressive seizure-induced impairments and co-morbid d... Read More about Cognitive dysfunction in naturally occurring canine idiopathic epilepsy.

Evaluation of the influence of kyphosis and scoliosis on intervertebral disc extrusion in French bulldogs (2018)
Journal Article
De Souza, M. C. C. M. I., Ryan, R., Ter Haar, G., Packer, R. M. A., Volk, H. A., & De Decker, S. (2018). Evaluation of the influence of kyphosis and scoliosis on intervertebral disc extrusion in French bulldogs. BMC Veterinary Research, 14, 5. https://doi.org/10.1186/s12917-017-1316-9

Although thoracic vertebral malformations with kyphosis and scoliosis are often considered incidental findings on diagnostic imaging studies of screw-tailed brachycephalic breeds, they have been suggested to interfere with spinal biomechanics and int... Read More about Evaluation of the influence of kyphosis and scoliosis on intervertebral disc extrusion in French bulldogs.

Negative effects of epilepsy and antiepileptic drugs on the trainability of dogs with naturally occurring idiopathic epilepsy (2018)
Journal Article
Packer, R. M. A., McGreevy, P. D., Pergande, A., & Volk, H. A. (2018). Negative effects of epilepsy and antiepileptic drugs on the trainability of dogs with naturally occurring idiopathic epilepsy. Applied Animal Behaviour Science, 200, 106-113. https://doi.org/10.1016/j.applanim.2017.11.008

Epilepsy and anti-epileptic drug (AED) treatment have been found to induce or exacerbate underlying cognitive impairments in people, affecting learning ability, attention and memory. Idiopathic epilepsy (IE) is the most common chronic neurological co... Read More about Negative effects of epilepsy and antiepileptic drugs on the trainability of dogs with naturally occurring idiopathic epilepsy.

Physiological reactivity to spontaneously occurring seizure activity in dogs with epilepsy and their carers (2017)
Journal Article
Packer, R. M. A., Volk, H. A., & Fowkes, R. C. (2017). Physiological reactivity to spontaneously occurring seizure activity in dogs with epilepsy and their carers. Physiology and Behavior, 177, 27-33. https://doi.org/10.1016/j.physbeh.2017.04.008

There is a complex bidirectional relationship between stress and epilepsy. Stressful stimuli and subsequent cortisol release act as a trigger for seizure activity in some individuals with epilepsy, and seizure activity itself may act as a stressor to... Read More about Physiological reactivity to spontaneously occurring seizure activity in dogs with epilepsy and their carers.

Clinical reasoning in feline epilepsy: Which combination of clinical information is useful? (2017)
Journal Article
Stanciu, G. D., Packer, R. M. A., Pakozdy, A., Solcan, G., & Volk, H. A. (2017). Clinical reasoning in feline epilepsy: Which combination of clinical information is useful?. https://doi.org/10.1016/j.tvjl.2017.04.001

We sought to identify the association between clinical risk factors and the diagnosis of idiopathic epilepsy (IE) or structural epilepsy (SE) in cats, using statistical models to identify combinations of discrete parameters from the patient signalmen... Read More about Clinical reasoning in feline epilepsy: Which combination of clinical information is useful?.

Evaluation of magnetic resonance imaging guidelines for differentiation between thoracolumbar intervertebral disk extrusions and intervertebral disk protrusions in dogs (2016)
Journal Article
De Decker, S., Gomes, S. A., Packer, R. M. A., Kenny, P. J., Beltran, E., Parzefall, B., Fenn, J. T., Nair, D., Nye, G., & Volk, H. A. (2016). Evaluation of magnetic resonance imaging guidelines for differentiation between thoracolumbar intervertebral disk extrusions and intervertebral disk protrusions in dogs. https://doi.org/10.1111/vru.12394

Four MRI variables have recently been suggested to be independently associated with a diagnosis of thoracolumbar intervertebral disk extrusion or protrusion. Midline intervertebral disk herniation, and partial intervertebral disk degeneration were as... Read More about Evaluation of magnetic resonance imaging guidelines for differentiation between thoracolumbar intervertebral disk extrusions and intervertebral disk protrusions in dogs.

Risk factors for cluster seizures in canine idiopathic epilepsy (2016)
Journal Article
Packer, R. M. A., Shihab, N. K., Torres, B. B. J., & Volk, H. A. (2016). Risk factors for cluster seizures in canine idiopathic epilepsy. Research in Veterinary Science, 105, 136-138. https://doi.org/10.1016/j.rvsc.2016.02.005

Cluster seizures (CS), two or more seizures within a 24-hour period, are reported in 38–77% of dogs with idiopathic epilepsy (IE). Negative outcomes associated with CS include a reduced likelihood of achieving seizure freedom, decreased survival time... Read More about Risk factors for cluster seizures in canine idiopathic epilepsy.

Impact of facial conformation on canine health: Brachycephalic Obstructive Airway Syndrome (2015)
Journal Article
Packer, R. M. A., Hendricks, A., Tivers, M. S., & Burn, C. C. (2015). Impact of facial conformation on canine health: Brachycephalic Obstructive Airway Syndrome. PLoS ONE, 10(10), https://doi.org/10.1371/journal.pone.0137496

The domestic dog may be the most morphologically diverse terrestrial mammalian species known to man; pedigree dogs are artificially selected for extreme aesthetics dictated by formal Breed Standards, and breed-related disorders linked to conformation... Read More about Impact of facial conformation on canine health: Brachycephalic Obstructive Airway Syndrome.

Impact of Facial Conformation on Canine Health: Corneal Ulceration (2015)
Journal Article
Packer, R. M. A., Hendricks, A., & Burn, C. C. (2015). Impact of Facial Conformation on Canine Health: Corneal Ulceration. PLoS ONE, 10(5), e0123827. https://doi.org/10.1371/journal.pone.0123827

Concern has arisen in recent years that selection for extreme facial morphology in the domestic dog may be leading to an increased frequency of eye disorders. Corneal ulcers are a common and painful eye problem in domestic dogs that can lead to scarr... Read More about Impact of Facial Conformation on Canine Health: Corneal Ulceration.

How Long and Low Can You Go? Effect of Conformation on the Risk of Thoracolumbar Intervertebral Disc Extrusion in Domestic Dogs (2013)
Journal Article
Packer, R. M. A., Hendricks, A., Volk, H. A., Shihab, N. K., & Burn, C. C. (2013). How Long and Low Can You Go? Effect of Conformation on the Risk of Thoracolumbar Intervertebral Disc Extrusion in Domestic Dogs. PLoS ONE, 8(7), e69650. https://doi.org/10.1371/journal.pone.0069650

Intervertebral disc extrusion (IVDE) is a common neurological disorder in certain dog breeds, resulting in spinal cord compression and injury that can cause pain and neurological deficits. Most disc extrusions are reported in chondrodystrophic breeds... Read More about How Long and Low Can You Go? Effect of Conformation on the Risk of Thoracolumbar Intervertebral Disc Extrusion in Domestic Dogs.