The deubiquitylase USP9X controls ribosomal stalling

Clancy, A; Heride, C; Pinto-Fernandez, A; Elcocks, H; Kallinos, A; Kayser-Bricker, KJ; Wang, WP; Smith, V; Davis, S; Fessler, S; McKinnon, C; Katz, M; Hammonds, T; Jones, NP; O'Connell, J; Follows, B; Mischke, S; Caravella, JA; Ioannidis, S; Dinsmore, C; Kim, S; Behrens, A; Komander, D; Kessler, BM; Urbe, S; Clague, MJ

doi:10.1083/jcb.202004211

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The deubiquitylase USP9X controls ribosomal stalling (2021)
Journal Article
Clancy, A., Heride, C., Pinto-Fernandez, A., Elcocks, H., Kallinos, A., Kayser-Bricker, K., …Clague, M. (2021). The deubiquitylase USP9X controls ribosomal stalling. Journal of Cell Biology, 220(3), https://doi.org/10.1083/jcb.202004211

When a ribosome stalls during translation, it runs the risk of collision with a trailing ribosome. Such an encounter leads to the formation of a stable di-ribosome complex, which needs to be resolved by a dedicated machinery. The initial stalling and... Read More about The deubiquitylase USP9X controls ribosomal stalling.