All Outputs (33)

Differential pharmacokinetics and pharmacokinetic/pharmacodynamic modelling of robenacoxib and ketoprofen in a feline model of inflammation (2014)
Journal Article
Pelligand, L., King, J. N., Hormazabal, V., Toutain, P. L., Elliott, J., & Lees, P. (2014). Differential pharmacokinetics and pharmacokinetic/pharmacodynamic modelling of robenacoxib and ketoprofen in a feline model of inflammation. Journal of Veterinary Pharmacology and Therapeutics, 37(4), 354-366. https://doi.org/10.1111/jvp.12107

Robenacoxib and ketoprofen are acidic nonsteroidal anti‐inflammatory drugs (NSAIDs). Both are licensed for once daily administration in the cat, despite having short blood half‐lives. This study reports the pharmacokinetic/pharmacodynamic (PK/PD) mod... Read More about Differential pharmacokinetics and pharmacokinetic/pharmacodynamic modelling of robenacoxib and ketoprofen in a feline model of inflammation.

Low Density Lipoprotein Receptor-related Protein 1 (LRP1)-mediated Endocytic Clearance of a Disintegrin and Metalloproteinase with Thrombospondin Motifs-4 (ADAMTS-4) FUNCTIONAL DIFFERENCES OF NON-CATALYTIC DOMAINS OF ADAMTS-4 AND ADAMTS-5 IN LRP1 BINDING (2014)
Journal Article
Yamamoto, K., Owen, K., Parker, A. E., Scilabra, S. D., Dudhia, J., Strickland, D. K., …Nagase, H. (2014). Low Density Lipoprotein Receptor-related Protein 1 (LRP1)-mediated Endocytic Clearance of a Disintegrin and Metalloproteinase with Thrombospondin Motifs-4 (ADAMTS-4) FUNCTIONAL DIFFERENCES OF NON-CATALYTIC DOMAINS OF ADAMTS-4 AND ADAMTS-5 IN LRP1 BINDING. Journal of Biological Chemistry, 289(10), 6462-6474. https://doi.org/10.1074/jbc.M113.545376

Degradation of the cartilage proteoglycan aggrecan is an early event in the development of osteoarthritis, and a disintegrin and metalloproteinase with thrombospondin motifs-4 (ADAMTS-4) and ADAMTS-5 are considered to be the major aggrecan-degrading... Read More about Low Density Lipoprotein Receptor-related Protein 1 (LRP1)-mediated Endocytic Clearance of a Disintegrin and Metalloproteinase with Thrombospondin Motifs-4 (ADAMTS-4) FUNCTIONAL DIFFERENCES OF NON-CATALYTIC DOMAINS OF ADAMTS-4 AND ADAMTS-5 IN LRP1 BINDING.

Veterinary management of starved and neglected horses (2014)
Journal Article
Johns, I. C. (2014). Veterinary management of starved and neglected horses. In Practice, 36(3), https://doi.org/10.1136/inp.g1539

Starved and neglected horses can be encountered in equine practice, and veterinary surgeons have a responsibility to both treat the animal and educate the owners on animal welfare; in some cases, they may also have to deal with the authorities to sei... Read More about Veterinary management of starved and neglected horses.

Ornithine Phenylacetate targets alterations in the expression and activity of Glutamine Synthase and Glutaminase to reduce ammonia levels in bile duct ligated rats (2014)
Journal Article
Jover-Cobos, M., Noiret, L., Lee, K. C. L., Sharma, V., Habtesion, A., Romero-Gomez, M., …Jalan, R. (2014). Ornithine Phenylacetate targets alterations in the expression and activity of Glutamine Synthase and Glutaminase to reduce ammonia levels in bile duct ligated rats. Journal of Hepatology, 60(3), 545-553. https://doi.org/10.1016/j.jhep.2013.10.012

Background & Aims: In liver failure, ammonia homeostasis is dependent upon the function of the ammonia metabolising enzymes, glutamine synthetase (GS) and glutaminase (GA) but data about their protein expression and activity are lacking. The aims of... Read More about Ornithine Phenylacetate targets alterations in the expression and activity of Glutamine Synthase and Glutaminase to reduce ammonia levels in bile duct ligated rats.

Adenovirus-mediated expression of Myogenic Differentiation Factor 1 (MyoD) in equine and human dermal fibroblasts enables their conversion to caffeine-sensitive myotubes (2014)
Journal Article
Fernandez-Fuente, M., Martin-Duque, P., Vassaux, G., Brown, S. C., Muntoni, F., Terracciano, C. M., & Piercy, R. J. (2014). Adenovirus-mediated expression of Myogenic Differentiation Factor 1 (MyoD) in equine and human dermal fibroblasts enables their conversion to caffeine-sensitive myotubes. Neuromuscular Disorders, 24(3), 250-258. https://doi.org/10.1016/j.nmd.2013.11.009

Several human and animal myopathies, such as malignant hyperthermia (MH), central core disease and equine recurrent exertional rhabdomyolysis (RER) are confirmed or thought to be associated with dysfunction of skeletal muscle calcium regulation. For... Read More about Adenovirus-mediated expression of Myogenic Differentiation Factor 1 (MyoD) in equine and human dermal fibroblasts enables their conversion to caffeine-sensitive myotubes.

Proteomic Analysis of Tendon Extracellular Matrix Reveals Disease Stage- specific Fragmentation and Differential Cleavage of COMP ( Cartilage Oligomeric Matrix Protein) (2014)
Journal Article
Dakin, S. G., Smith, R. K. W., Heinegard, D., Onnerfjord, P., Khabut, A., & Dudhia, J. (2014). Proteomic Analysis of Tendon Extracellular Matrix Reveals Disease Stage- specific Fragmentation and Differential Cleavage of COMP ( Cartilage Oligomeric Matrix Protein). Journal of Biological Chemistry, 289(8), 4919-4927. https://doi.org/10.1074/jbc.M113.511972

During inflammatory processes the extracellular matrix (ECM) is extensively remodeled, and many of the constituent components are released as proteolytically cleaved fragments. These degradative processes are better documented for inflammatory joint... Read More about Proteomic Analysis of Tendon Extracellular Matrix Reveals Disease Stage- specific Fragmentation and Differential Cleavage of COMP ( Cartilage Oligomeric Matrix Protein).

Homologous and heterologous desensitization of guanylyl cyclase-B signaling in GH3 somatolactotropes (2014)
Journal Article
Thompson, I. R., Mirczuk, S. M., Smith, L., Lessey, A. J., Simbi, B., Sunters, A., …Fowkes, R. C. (2014). Homologous and heterologous desensitization of guanylyl cyclase-B signaling in GH3 somatolactotropes. Cell and Tissue Research, 355(2), 425-36. https://doi.org/10.1007/s00441-013-1763-y

The guanylyl cyclases, GC-A and GC-B, are selective receptors for atrial and C-type natriuretic peptides (ANP and CNP, respectively). In the anterior pituitary, CNP and GC-B are major regulators of cGMP production in gonadotropes and yet mouse models... Read More about Homologous and heterologous desensitization of guanylyl cyclase-B signaling in GH3 somatolactotropes.

Spatial multi-criteria decision analysis to predict suitability for African swine fever endemicity in Africa (2014)
Journal Article
De Glanville, W. A., Vial, L., Costard, S., Wieland, B., & Pfeiffer, D. U. (2014). Spatial multi-criteria decision analysis to predict suitability for African swine fever endemicity in Africa. BMC Veterinary Research, 10, https://doi.org/10.1186/1746-6148-10-9

Hyperammonemia and Systemic Inflammatory Response Syndrome Predicts Presence of Hepatic Encephalopathy in Dogs with Congenital Portosystemic Shunts (2014)
Journal Article
Tivers, M. S., Handel, I., Gow, A. G., Lipscomb, V. J., Jalan, R., & Mellanby, R. (2014). Hyperammonemia and Systemic Inflammatory Response Syndrome Predicts Presence of Hepatic Encephalopathy in Dogs with Congenital Portosystemic Shunts. PLoS ONE, 9(1), https://doi.org/10.1371/journal.pone.0082303

Hepatic encephalopathy (HE) is an important cause of morbidity and mortality in patients with liver disease. The pathogenesis of he is incompletely understood although ammonia and inflammatory cytokines have been implicated as key mediators. To facil... Read More about Hyperammonemia and Systemic Inflammatory Response Syndrome Predicts Presence of Hepatic Encephalopathy in Dogs with Congenital Portosystemic Shunts.

Diet composition, food intake, apparent digestibility, and body condition score of the captive asian elephant (elephas maximus): a pilot study in two collections in Thailand (2014)
Journal Article
Romain, S., Angkawanish, T., Bampenpol, P., Pongsopawijit, P., Sombatphuthorn, P., Nomsiri, R., & Silva-Fletcher, A. T. (2014). Diet composition, food intake, apparent digestibility, and body condition score of the captive asian elephant (elephas maximus): a pilot study in two collections in Thailand. Journal of Zoo and Wildlife Medicine, 45(1), 1-14. https://doi.org/10.1638/2011-0261r3.1

Limited data are available regarding the nutrition and feeding of captive Asian elephants in range countries. In this study, feeding regimens of two collections in northern Thailand and their actual diets shaped by availability of forage and mahout p... Read More about Diet composition, food intake, apparent digestibility, and body condition score of the captive asian elephant (elephas maximus): a pilot study in two collections in Thailand.

Identifying optimal parameters for quantification of changes in pelvic movement symmetry as a response to diagnostic analgesia in the hindlimbs of horses (2014)
Journal Article
Pfau, T., Spicer-Jenkins, C., Smith, R. K. W., Bolt, D. M., Fiske-Jackson, A. R., & Witte, T. H. (2014). Identifying optimal parameters for quantification of changes in pelvic movement symmetry as a response to diagnostic analgesia in the hindlimbs of horses. Equine Veterinary Journal, 46(6), 759-763. https://doi.org/10.1111/evj.12220

Signalment, clinical presentation, and diagnostic findings in 122 dogs with spinal arachnoid diverticula (2014)
Journal Article
Mauler, D. A., De Decker, S., De Risio, L., Volk, H. A., Dennis, R., Gielen, I., …Van Ham, L. (2014). Signalment, clinical presentation, and diagnostic findings in 122 dogs with spinal arachnoid diverticula. Journal of Veterinary Internal Medicine, 28(1), 175-81. https://doi.org/10.1111/jvim.12241

Plasma renin activity and aldosterone concentrations in hypertensive cats with and without azotemia and in response to treatment with amlodipine besylate (2014)
Journal Article
Jepson, R. E., Syme, H. M., & Elliott, J. (2014). Plasma renin activity and aldosterone concentrations in hypertensive cats with and without azotemia and in response to treatment with amlodipine besylate. Journal of Veterinary Internal Medicine, 28(1), 144-53. https://doi.org/10.1111/jvim.12240