A key role for beta-cell cytosolic phospholipase A(2) in the maintenance of insulin stores but not in the initiation of insulin secretion
Journal Article
Persaud, S. J., Roderigo-Milne, H. M., Squires, P. E., Sugden, D., Wheeler-Jones, C. P. D., Marsh, P. J., …Jones, P. M. A key role for beta-cell cytosolic phospholipase A(2) in the maintenance of insulin stores but not in the initiation of insulin secretion. Diabetes, 51(1), 98-104
All Outputs (96)
Chylomicron remnants: mediators of endothelial dysfunction?
Conference Proceeding
Wheeler-Jones, C. P. D. Chylomicron remnants: mediators of endothelial dysfunction?
sPLA(2) cooperates with cPLA(2)alpha to regulate prostacyclin synthesis in human endothelial cells
Journal Article
Houliston, R. A., & Wheeler-Jones, C. P. D. sPLA(2) cooperates with cPLA(2)alpha to regulate prostacyclin synthesis in human endothelial cells. Biochemical and Biophysical Research Communications, 287(4), 881-887. https://doi.org/10.1006/bbrc.2001.5681
Agonist-specific cross talk between ERKs and p38(mapk) regulates PGI(2) synthesis in endothelium
Journal Article
Houliston, R. A., Pearson, J. D., & Wheeler-Jones, C. P. D. Agonist-specific cross talk between ERKs and p38(mapk) regulates PGI(2) synthesis in endothelium
Mechanical strain and estrogen activate estrogen receptor alpha in bone cells
Journal Article
Jessop, H. L., Sjoberg, M., Cheng, M. Z., Zaman, G., Wheeler-Jones, C. P. D., & Lanyon, L. E. Mechanical strain and estrogen activate estrogen receptor alpha in bone cells. Journal of Bone and Mineral Research, 16(6), 1045-1055. https://doi.org/10.1359/jbmr.2001.16.6.1045
Protease-activated receptors, cyclo-oxygenases and pro-angiogenic signalling in endothelial cells
Journal Article
Wheeler-Jones, C. P. D., Farrar, C. E., & Garonna, E. Protease-activated receptors, cyclo-oxygenases and pro-angiogenic signalling in endothelial cells. Biochemical Society Transactions, 37, 1179-1183. https://doi.org/10.1042/bst0371179
Molecular characterisation and functional interrogation of a local natriuretic peptide system in rodent pituitaries, alpha T3-1 and L beta T2 gonadotroph cells
Journal Article
Thompson, I. R., Chand, A. N., Jonas, K. C., Burrin, J. M., Steinhelper, M. E., Wheeler-Jones, C. P. D., …Fowkes, R. C. Molecular characterisation and functional interrogation of a local natriuretic peptide system in rodent pituitaries, alpha T3-1 and L beta T2 gonadotroph cells. Journal of Endocrinology, 203(2), 215-229. https://doi.org/10.1677/joe-09-0189
Celecoxib activates PI-3K/Akt and mitochondrial redox signaling to enhance heme oxygenase-1-mediated anti-inflammatory activity in vascular endothelium
Journal Article
Hamdulay, S. S., Wang, B. F., Birdsey, G. M., Ali, F., Dumont, O., Evans, P. C., …Mason, J. C. Celecoxib activates PI-3K/Akt and mitochondrial redox signaling to enhance heme oxygenase-1-mediated anti-inflammatory activity in vascular endothelium. Free Radical Biology and Medicine, 48(8), 1013-1023. https://doi.org/10.1016/j.freeradbiomed.2010.01.017
CELECOXIB ENHANCES ENDOTHELIAL HO-1 EXPRESSION AND ACTIVITY: A NOVEL MECHANISM OF VASCULAR CYTOPROTECTION
Journal Article
Hamdulay, S. S., Wang, B. F., Haskard, D. O., Wheeler-Jones, C. P. D., & Mason, J. CELECOXIB ENHANCES ENDOTHELIAL HO-1 EXPRESSION AND ACTIVITY: A NOVEL MECHANISM OF VASCULAR CYTOPROTECTION
Suppression of nuclear factor-kappaB activity in macrophages by chylomicron remnants: modulation by the fatty acid composition of the particles
Journal Article
De Pascale, C., Graham, V., Fowkes, R. C., Wheeler-Jones, C. P. D., & Botham, K. M. Suppression of nuclear factor-kappaB activity in macrophages by chylomicron remnants: modulation by the fatty acid composition of the particles. FEBS Journal, 276(19), 5689-5702. https://doi.org/10.1111/j.1742-4658.2009.07260.x
Regulation of platelet activating factor-induced equine platelet activation by intracellular kinases
Journal Article
Brooks, A. C., Menzies-Gow, N. J., Wheeler-Jones, C. P. D., Bailey, S. R., Elliott, J., & Cunningham, F. M. Regulation of platelet activating factor-induced equine platelet activation by intracellular kinases. Journal of Veterinary Pharmacology and Therapeutics, 32(2), 189-196. https://doi.org/10.1111/j.1365-2885.2008.01020.xLipopolysaccharide (LPS) can activate equine platelets directly or indirectly, via leukocyte-derived platelet activating factor (PAF). Thromboxane (Tx) production by LPS-stimulated equine platelets requires p38 MAPK and this kinase has been suggested... Read More about Regulation of platelet activating factor-induced equine platelet activation by intracellular kinases.
Endotoxin-induced activation of equine digital vein endothelial cells: Role of p38 MAPK
Journal Article
Brooks, A. C., Menzies-Gow, N. J., Wheeler-Jones, C. P. D., Bailey, S. R., Cunningham, F. M., & Elliott, J. Endotoxin-induced activation of equine digital vein endothelial cells: Role of p38 MAPK. Veterinary Immunology and Immunopathology, 129(3-4), 174-180. https://doi.org/10.1016/j.vetimm.2008.11.008
Targeting hyaluronan of the endothelial glycocalyx for therapeutic intervention
Journal Article
Wheeler-Jones, C. P. D., Farrar, C. E., & Pitsillides, A. A. Targeting hyaluronan of the endothelial glycocalyx for therapeutic intervention
C-type natriuretic peptide regulation of guanosine-3',5'-cyclic monophosphate production in human endothelial cells
Journal Article
Rautureau, Y., Gowers, I., Wheeler-Jones, C. P. D., & Baxter, G. F. C-type natriuretic peptide regulation of guanosine-3',5'-cyclic monophosphate production in human endothelial cells. https://doi.org/10.1111/j.1474-8673.2009.00449.x
Paracrine Stimulation of Endothelial Cell Motility and Angiogenesis by Platelet-Derived Deoxyribose-1-Phosphate
Journal Article
Pula, G., Garonna, E., Dunn, W. B., Hirano, M., Pizzorno, G., Campanella, M., …Wheeler-Jones, C. P. D. Paracrine Stimulation of Endothelial Cell Motility and Angiogenesis by Platelet-Derived Deoxyribose-1-Phosphate. Arteriosclerosis, Thrombosis, and Vascular Biology, 30(12), 2631-8. https://doi.org/10.1161/atvbaha.110.215855
The effect of estradiol on COX-2, EP2, and EP4 mRNA expression and the extracellular matrix in the cervix of the hypogonadotrophic, ovariectomized ewe
Journal Article
Kershaw-Young, C. M., Scaramuzzi, R. J., McGowan, M. R., Pitsillides, A. A., Wheeler-Jones, C. P. D., & Khalid, M. The effect of estradiol on COX-2, EP2, and EP4 mRNA expression and the extracellular matrix in the cervix of the hypogonadotrophic, ovariectomized ewe. Theriogenology, 73(5), 620-628. https://doi.org/10.1016/j.theriogenology.2009.10.018
Selective activation of the MEK-ERK pathway is regulated by mechanical stimuli in forming joints and promotes pericellular matrix formation
Journal Article
Bastow, E. R., Lamb, K. J., Lewthwaite, J. C., Osborne, A. C., Kavanagh, E., Wheeler-Jones, C. P. D., & Pitsillides, A. A. Selective activation of the MEK-ERK pathway is regulated by mechanical stimuli in forming joints and promotes pericellular matrix formation. Journal of Biological Chemistry, 280(12), 11749-11758. https://doi.org/10.1074/jbc.M414495200
The expression of prostaglandin endoperoxide synthase 2 messenger RNA and the proportion of smooth muscle and collagen in the sheep cervix during the estrous cycle
Journal Article
Kershaw, C. M., Scaramuzzi, R. J., McGowan, M. R., Wheeler-Jones, C. P. D., & Khalid, M. The expression of prostaglandin endoperoxide synthase 2 messenger RNA and the proportion of smooth muscle and collagen in the sheep cervix during the estrous cycle. Biology of Reproduction, 76(1), 124-129. https://doi.org/10.1095/biolreprod.106.054049
Effects of lycopene on the induction of foam cell formation by modified LDL
Journal Article
Napolitano, M., De Pascale, C., Wheeler-Jones, C. P. D., Botham, K. M., & Bravo, E. Effects of lycopene on the induction of foam cell formation by modified LDL. https://doi.org/10.1152/ajpendo.00315.2007The effect of lycopene on macrophage foam cell formation induced by modified low-density lipoprotein (LDL) was studied. Human monocyte-derived macrophages (HMDM) were incubated with lycopene in the presence or absence of native LDL (nLDL) or LDL modi... Read More about Effects of lycopene on the induction of foam cell formation by modified LDL.
Uptake of 5-hydroxytryptamine by equine digital vein endothelial cells: inhibition by amines found in the equine caecum
Journal Article
Bailey, S. R., Wheeler-Jones, C. P. D., & Elliott, J. Uptake of 5-hydroxytryptamine by equine digital vein endothelial cells: inhibition by amines found in the equine caecum. Equine Veterinary Journal, 35(2), 164-169. https://doi.org/10.2746/042516403776114171