All Outputs (48)

Homologous and heterologous desensitization of guanylyl cyclase-B signaling in GH3 somatolactotropes (2014)
Journal Article
Thompson, I. R., Mirczuk, S. M., Smith, L., Lessey, A. J., Simbi, B., Sunters, A., …Fowkes, R. C. (2014). Homologous and heterologous desensitization of guanylyl cyclase-B signaling in GH3 somatolactotropes. Cell and Tissue Research, 355(2), 425-36. https://doi.org/10.1007/s00441-013-1763-y

The guanylyl cyclases, GC-A and GC-B, are selective receptors for atrial and C-type natriuretic peptides (ANP and CNP, respectively). In the anterior pituitary, CNP and GC-B are major regulators of cGMP production in gonadotropes and yet mouse models... Read More about Homologous and heterologous desensitization of guanylyl cyclase-B signaling in GH3 somatolactotropes.

Nrf2 impacts the efficiency of mitochondrial fatty acid oxidation (2014)
Journal Article
Ludtmann, M. H. R., Angelova, P. R., Zhang, Y., Abramov, A. Y., & Dinkova-Kostova, A. T. (2014). Nrf2 impacts the efficiency of mitochondrial fatty acid oxidation. Biochemical Journal, 457(3), 415-424. https://doi.org/10.1042/BJ20130863

Transcription factor Nrf2 (NF-E2 p45-related factor 2) regulates the cellular redox homoeostasis and cytoprotective responses, allowing adaptation and survival under conditions of stress. The significance of Nrf2 in intermediary metabolism is also be... Read More about Nrf2 impacts the efficiency of mitochondrial fatty acid oxidation.

Flexibility within the Heads of Muscle Myosin-2 Molecules (2014)
Journal Article
Billington, N., Revill, D. J., Burgess, S. A., Chantler, P. D., & Knight, P. J. (2014). Flexibility within the Heads of Muscle Myosin-2 Molecules. Journal of Molecular Biology, 426(4), 894-907. https://doi.org/10.1016/j.jmb.2013.11.028

We show that negative-stain electron microscopy and image processing of nucleotide-free (apo) striated muscle myosin-2 subfragment-1 (S1), possessing one light chain or both light chains, is capable of resolving significant amounts of structural deta... Read More about Flexibility within the Heads of Muscle Myosin-2 Molecules.

Pulsatile Hormonal Signaling to Extracellular Signal-Regulated Kinase: Exploring System Sensitivity to Gonadotropin-Releasing Hormone Pulse Frequency and Width (2014)
Journal Article
Perrett, R. M., Voliotis, M., Armstrong, S. P., Fowkes, R. C., Pope, G. R., Tsaneva-Atanasova, K., & McArdle, C. A. (2014). Pulsatile Hormonal Signaling to Extracellular Signal-Regulated Kinase: Exploring System Sensitivity to Gonadotropin-Releasing Hormone Pulse Frequency and Width. Journal of Biological Chemistry, 289(11), 7873-7883. https://doi.org/10.1074/jbc.M113.532473

Gonadotropin-releasing hormone (GnRH) is secreted in brief pulses that stimulate synthesis and secretion of pituitary gonadotropin hormones and thereby mediate control of reproduction. It acts via G-protein-coupled receptors to stimulate effectors, i... Read More about Pulsatile Hormonal Signaling to Extracellular Signal-Regulated Kinase: Exploring System Sensitivity to Gonadotropin-Releasing Hormone Pulse Frequency and Width.

Upwash exploitation and downwash avoidance by flap phasing in ibis formation flight (2014)
Journal Article
Portugal, S. J., Hubel, T. Y., Fritz, J., Heese, S., Trobe, D., Voelkl, B., …Usherwood, J. R. (2014). Upwash exploitation and downwash avoidance by flap phasing in ibis formation flight. Nature, 505(7483), 399-+. https://doi.org/10.1038/nature12939

Many species travel in highly organized groups. The most quoted function of these configurations is to reduce energy expenditure and enhance locomotor performance of individuals in the assemblage. The distinctive V formation of bird flocks has long i... Read More about Upwash exploitation and downwash avoidance by flap phasing in ibis formation flight.

Propeptide-Mediated Inhibition of Myostatin Increases Muscle Mass Through Inhibiting Proteolytic Pathways in Aged Mice (2014)
Journal Article
Collins-Hooper, H., Sartori, R., Macharia, R., Visanuvimol, K., Foster, K., Matsakas, A., …Patel, K. (2014). Propeptide-Mediated Inhibition of Myostatin Increases Muscle Mass Through Inhibiting Proteolytic Pathways in Aged Mice. https://doi.org/10.1093/gerona/glt170

Mammalian aging is accompanied by a progressive loss of skeletal muscle, a process called sarcopenia. Myostatin, a secreted member of the transforming growth factor-β family of signaling molecules, has been shown to be a potent inhibitor of muscle gr... Read More about Propeptide-Mediated Inhibition of Myostatin Increases Muscle Mass Through Inhibiting Proteolytic Pathways in Aged Mice.

Fascicles from energy-storing tendons show an age-specific response to cyclic fatigue loading (2014)
Journal Article
Thorpe, C. T., Riley, G. P., Birch, H. L., Clegg, P. D., & Screen, H. R. C. (2014). Fascicles from energy-storing tendons show an age-specific response to cyclic fatigue loading. https://doi.org/10.1098/rsif.2013.1058

Some tendons, such as the human Achilles and equine superficial digital flexor tendon (SDFT), act as energy stores, stretching and recoiling to increase efficiency during locomotion. Our previous observations of rotation in response to applied strain... Read More about Fascicles from energy-storing tendons show an age-specific response to cyclic fatigue loading.

Reconsidering the Lecture in Modern Veterinary Education (2014)
Journal Article
Campanella, M., & Lygo-Baker, S. (2014). Reconsidering the Lecture in Modern Veterinary Education. Journal of Veterinary Medical Education, 41(2), 138-145. https://doi.org/10.3138/jvme.0713-097R

Those teaching in the higher-education environment are now increasingly meeting with larger cohorts of students. The result is additional pressure on the resources available and on the teacher and learners. Against this backdrop, discussions and refl... Read More about Reconsidering the Lecture in Modern Veterinary Education.