Targeting hyaluronan of the endothelial glycocalyx for therapeutic intervention
Journal Article
Wheeler-Jones, C. P. D., Farrar, C. E., & Pitsillides, A. A. Targeting hyaluronan of the endothelial glycocalyx for therapeutic intervention
All Outputs (99)
C-type natriuretic peptide regulation of guanosine-3',5'-cyclic monophosphate production in human endothelial cells
Journal Article
Rautureau, Y., Gowers, I., Wheeler-Jones, C. P. D., & Baxter, G. F. C-type natriuretic peptide regulation of guanosine-3',5'-cyclic monophosphate production in human endothelial cells. https://doi.org/10.1111/j.1474-8673.2009.00449.x
Direct interaction of dietary lipids carried in chylomicron remnants with cells of the artery wall: Implications for atherosclerosis development
Journal Article
Botham, K. M., Bravo, E., Elliott, J., & Wheeler-Jones, C. P. D. Direct interaction of dietary lipids carried in chylomicron remnants with cells of the artery wall: Implications for atherosclerosis development. Current Pharmaceutical Design, 11(28), 3681-3695. https://doi.org/10.2174/138161205774580732
Endotoxin-induced activation of equine platelets: evidence for direct activation of p38 MAPK pathways and vasoactive mediator production
Journal Article
Brooks, A. C., Menzies-Gow, N. J., Wheeler-Jones, C. P. D., Bailey, S. R., Cunningham, F. M., & Elliott, J. Endotoxin-induced activation of equine platelets: evidence for direct activation of p38 MAPK pathways and vasoactive mediator production. Inflammation Research, 56(4), 154-161. https://doi.org/10.1007/s00011-006-6151-6
Highly homologous Mycobacterium tuberculosis chaperonin 60 proteins with differential CD14 dependencies stimulate cytokine production by human monocytes through cooperative activation of p38 and ERK1/2 mitogen-activated protein kinases
Journal Article
Lewthwaite, J. C., Clarkin, C. E., Coates, A. R. M., Poole, S., Lawrence, R. A., Wheeler-Jones, C. P. D., …Henderson, B. Highly homologous Mycobacterium tuberculosis chaperonin 60 proteins with differential CD14 dependencies stimulate cytokine production by human monocytes through cooperative activation of p38 and ERK1/2 mitogen-activated protein kinases. International Immunopharmacology, 7(2), 230-240. https://doi.org/10.1016/j.intimp.2006.10.005
The expression of prostaglandin endoperoxide synthase 2 messenger RNA and the proportion of smooth muscle and collagen in the sheep cervix during the estrous cycle
Journal Article
Kershaw, C. M., Scaramuzzi, R. J., McGowan, M. R., Wheeler-Jones, C. P. D., & Khalid, M. The expression of prostaglandin endoperoxide synthase 2 messenger RNA and the proportion of smooth muscle and collagen in the sheep cervix during the estrous cycle. Biology of Reproduction, 76(1), 124-129. https://doi.org/10.1095/biolreprod.106.054049
Effects of lycopene on the induction of foam cell formation by modified LDL
Journal Article
Napolitano, M., De Pascale, C., Wheeler-Jones, C. P. D., Botham, K. M., & Bravo, E. Effects of lycopene on the induction of foam cell formation by modified LDL. https://doi.org/10.1152/ajpendo.00315.2007The effect of lycopene on macrophage foam cell formation induced by modified low-density lipoprotein (LDL) was studied. Human monocyte-derived macrophages (HMDM) were incubated with lycopene in the presence or absence of native LDL (nLDL) or LDL modi... Read More about Effects of lycopene on the induction of foam cell formation by modified LDL.
Uptake of 5-hydroxytryptamine by equine digital vein endothelial cells: inhibition by amines found in the equine caecum
Journal Article
Bailey, S. R., Wheeler-Jones, C. P. D., & Elliott, J. Uptake of 5-hydroxytryptamine by equine digital vein endothelial cells: inhibition by amines found in the equine caecum. Equine Veterinary Journal, 35(2), 164-169. https://doi.org/10.2746/042516403776114171
Severity of lung injury in cyclooxygenase-2-deficient mice is dependent on reduced prostaglandin E-2 production
Journal Article
Hodges, R. J., Jenkins, R. G., Wheeler-Jones, C. P. D., Copeman, D. M., Bottoms, S. E., Bellingan, G. J., …McAnulty, R. J. Severity of lung injury in cyclooxygenase-2-deficient mice is dependent on reduced prostaglandin E-2 production. American Journal of Pathology, 165(5), 1663-1676. https://doi.org/10.1016/S0002-9440%2810%2963423-2
In-vitro contraction of the eauine aortic valve
Journal Article
Bowen, I. M., Marr, C. M., Chester, A. H., Wheeler-Jones, C. P. D., & Elliott, J. In-vitro contraction of the eauine aortic valve
Cell signalling in the cardiovascular system: an overview
Journal Article
Wheeler-Jones, C. P. D. Cell signalling in the cardiovascular system: an overview. Heart, 91(10), 1366-1374. https://doi.org/10.1136/hrt.2005.072280
Comparative cell signalling activity of ultrapure recombinant chaperonin 60 proteins from prokaryotes and eukaryotes
Journal Article
Maguire, M., Poole, S., Coates, A. R. M., Tormay, P., Wheeler-Jones, C. P. D., & Henderson, B. Comparative cell signalling activity of ultrapure recombinant chaperonin 60 proteins from prokaryotes and eukaryotes. Immunology, 115(2), 231-238. https://doi.org/10.1111/j.1365-2567.2005.02155.x
Regulation of endothelial prostacyclin synthesis by Protease-activated receptors: mechanisms and significance
Journal Article
Wheeler-Jones, C. P. D. Regulation of endothelial prostacyclin synthesis by Protease-activated receptors: mechanisms and significanceThe cellular actions of serine proteases are mediated through activation of a novel family of four G protein-coupled receptors known as protease-activated receptors (PARs). PARs are emerging as important modulators of diverse biological functions and... Read More about Regulation of endothelial prostacyclin synthesis by Protease-activated receptors: mechanisms and significance.
Selective activation of the MEK-ERK pathway is regulated by mechanical stimuli in forming joints and promotes pericellular matrix formation
Journal Article
Bastow, E. R., Lamb, K. J., Lewthwaite, J. C., Osborne, A. C., Kavanagh, E., Wheeler-Jones, C. P. D., & Pitsillides, A. A. Selective activation of the MEK-ERK pathway is regulated by mechanical stimuli in forming joints and promotes pericellular matrix formation. Journal of Biological Chemistry, 280(12), 11749-11758. https://doi.org/10.1074/jbc.M414495200
Cartilage oligomeric matrix protein and hyaluronan levels in synovial fluid from horses with osteoarthritis of the tarsometatarsal joint compared to a control population
Journal Article
Taylor, S. E., Weaver, M. P., Pitsillides, A. A., Wheeler, B. T., Wheeler-Jones, C. P. D., Shaw, D. J., & Smith, R. K. W. Cartilage oligomeric matrix protein and hyaluronan levels in synovial fluid from horses with osteoarthritis of the tarsometatarsal joint compared to a control population. Equine Veterinary Journal, 38(6), 502-507. https://doi.org/10.2746/042516406X156073
Cyclooxygenase-2 induction and prostacyclin release by protease-activated receptors in endothelial cells require cooperation between mitogen-activated protein kinase and NF-kappa B pathways
Journal Article
Syeda, F., Grosjean, J., Houliston, R. A., Keogh, R. J., Carter, T. D., Paleolog, E., & Wheeler-Jones, C. P. D. Cyclooxygenase-2 induction and prostacyclin release by protease-activated receptors in endothelial cells require cooperation between mitogen-activated protein kinase and NF-kappa B pathways. Journal of Biological Chemistry, 281(17), 11792-11804. https://doi.org/10.1074/jbc.M509292200
A specific mechanomodulatory role for p38 MAPK in embryonic joint articular surface cell MEK-ERK pathway regulation
Journal Article
Lewthwaite, J. C., Bastow, E. R., Lamb, K. J., Blenis, J., Wheeler-Jones, C. P. D., & Pitsillides, A. A. A specific mechanomodulatory role for p38 MAPK in embryonic joint articular surface cell MEK-ERK pathway regulation. Journal of Biological Chemistry, 281(16), 11011-11018. https://doi.org/10.1074/jbc.M510680200
Fatty acid composition of chylomicron remnant-like particles influences their uptake and induction of lipid accumulation in macrophages
Journal Article
De Pascale, C., Avella, M. A., Perona, J. S., Ruiz-Gutierrez, V., Wheeler-Jones, C. P. D., & Botham, K. M. Fatty acid composition of chylomicron remnant-like particles influences their uptake and induction of lipid accumulation in macrophages. FEBS Journal, 273(24), 5632-5640. https://doi.org/10.1111/j.1742-4658.2006.05552.x
Diverse range of fixed positional deformities and bone growth restraint provoked by flaccid paralysis in embryonic chicks
Journal Article
Lamb, K. J., Lewthwaite, J. C., Lin, J. P., Simon, D., Kavanagh, E., Wheeler-Jones, C. P. D., & Pitsillides, A. A. Diverse range of fixed positional deformities and bone growth restraint provoked by flaccid paralysis in embryonic chicks. International Journal of Experimental Pathology, 84(4), 191-199
Thrombin-stimnlated Pyk2 phosphorylation in human endothelium is dependent on intracellular calcium and independent of protein kinase C and Src kinases
Journal Article
Keogh, R. J., Houliston, R. A., & Wheeler-Jones, C. P. D. Thrombin-stimnlated Pyk2 phosphorylation in human endothelium is dependent on intracellular calcium and independent of protein kinase C and Src kinases. Biochemical and Biophysical Research Communications, 294(5), 1001-1008. https://doi.org/10.1016/S0006-291X%2802%2900568-5