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Cyclooxygenase-2 induction and prostacyclin release by protease-activated receptors in endothelial cells require cooperation between mitogen-activated protein kinase and NF-kappa B pathways
Journal Article
Syeda, F., Grosjean, J., Houliston, R. A., Keogh, R. J., Carter, T. D., Paleolog, E., & Wheeler-Jones, C. P. D. Cyclooxygenase-2 induction and prostacyclin release by protease-activated receptors in endothelial cells require cooperation between mitogen-activated protein kinase and NF-kappa B pathways. Journal of Biological Chemistry, 281(17), 11792-11804. https://doi.org/10.1074/jbc.M509292200

Cartilage oligomeric matrix protein and hyaluronan levels in synovial fluid from horses with osteoarthritis of the tarsometatarsal joint compared to a control population
Journal Article
Taylor, S. E., Weaver, M. P., Pitsillides, A. A., Wheeler, B. T., Wheeler-Jones, C. P. D., Shaw, D. J., & Smith, R. K. W. Cartilage oligomeric matrix protein and hyaluronan levels in synovial fluid from horses with osteoarthritis of the tarsometatarsal joint compared to a control population. Equine Veterinary Journal, 38(6), 502-507. https://doi.org/10.2746/042516406X156073

Selective activation of the MEK-ERK pathway is regulated by mechanical stimuli in forming joints and promotes pericellular matrix formation
Journal Article
Bastow, E. R., Lamb, K. J., Lewthwaite, J. C., Osborne, A. C., Kavanagh, E., Wheeler-Jones, C. P. D., & Pitsillides, A. A. Selective activation of the MEK-ERK pathway is regulated by mechanical stimuli in forming joints and promotes pericellular matrix formation. Journal of Biological Chemistry, 280(12), 11749-11758. https://doi.org/10.1074/jbc.M414495200

Effects of lycopene on the induction of foam cell formation by modified LDL
Journal Article
Napolitano, M., De Pascale, C., Wheeler-Jones, C. P. D., Botham, K. M., & Bravo, E. Effects of lycopene on the induction of foam cell formation by modified LDL. https://doi.org/10.1152/ajpendo.00315.2007

The effect of lycopene on macrophage foam cell formation induced by modified low-density lipoprotein (LDL) was studied. Human monocyte-derived macrophages (HMDM) were incubated with lycopene in the presence or absence of native LDL (nLDL) or LDL modi... Read More about Effects of lycopene on the induction of foam cell formation by modified LDL.

The expression of prostaglandin endoperoxide synthase 2 messenger RNA and the proportion of smooth muscle and collagen in the sheep cervix during the estrous cycle
Journal Article
Kershaw, C. M., Scaramuzzi, R. J., McGowan, M. R., Wheeler-Jones, C. P. D., & Khalid, M. The expression of prostaglandin endoperoxide synthase 2 messenger RNA and the proportion of smooth muscle and collagen in the sheep cervix during the estrous cycle. Biology of Reproduction, 76(1), 124-129. https://doi.org/10.1095/biolreprod.106.054049

Highly homologous Mycobacterium tuberculosis chaperonin 60 proteins with differential CD14 dependencies stimulate cytokine production by human monocytes through cooperative activation of p38 and ERK1/2 mitogen-activated protein kinases
Journal Article
Lewthwaite, J. C., Clarkin, C. E., Coates, A. R. M., Poole, S., Lawrence, R. A., Wheeler-Jones, C. P. D., Pitsillides, A. A., Singh, M., & Henderson, B. Highly homologous Mycobacterium tuberculosis chaperonin 60 proteins with differential CD14 dependencies stimulate cytokine production by human monocytes through cooperative activation of p38 and ERK1/2 mitogen-activated protein kinases. International Immunopharmacology, 7(2), 230-240. https://doi.org/10.1016/j.intimp.2006.10.005

Regulation of endothelial prostacyclin synthesis by Protease-activated receptors: mechanisms and significance
Journal Article
Wheeler-Jones, C. P. D. Regulation of endothelial prostacyclin synthesis by Protease-activated receptors: mechanisms and significance

The cellular actions of serine proteases are mediated through activation of a novel family of four G protein-coupled receptors known as protease-activated receptors (PARs). PARs are emerging as important modulators of diverse biological functions and... Read More about Regulation of endothelial prostacyclin synthesis by Protease-activated receptors: mechanisms and significance.

Evaluation of VEGF-Mediated signaling in primary human cells reveals a paracrine action for VEGF in osteoblast-mediated crosstalk to endothelial cells
Journal Article
Clarkin, C. E., Emery, R. J., Pitsillides, A. A., & Wheeler-Jones, C. P. D. Evaluation of VEGF-Mediated signaling in primary human cells reveals a paracrine action for VEGF in osteoblast-mediated crosstalk to endothelial cells. Journal of Cellular Physiology, 214(2), 537-544. https://doi.org/10.1002/jcp.21234

Communication between endothelial and bone cells is crucial for controlling vascular supply during bone growth, remodeling, and repair but the molecular mechanisms coordinating this intercellular crosstalk remain ill-defined. We have used primary hum... Read More about Evaluation of VEGF-Mediated signaling in primary human cells reveals a paracrine action for VEGF in osteoblast-mediated crosstalk to endothelial cells.

Heterotypic contact reveals a COX-2-mediated suppression of osteoblast differentiation by endothelial cells: A negative modulatory role for prostanoids in VEGF-mediated cell: cell communication?
Journal Article
Clarkin, C. E., Garonna, E., Pitsillides, A. A., & Wheeler-Jones, C. P. D. Heterotypic contact reveals a COX-2-mediated suppression of osteoblast differentiation by endothelial cells: A negative modulatory role for prostanoids in VEGF-mediated cell: cell communication?. Experimental Cell Research, 314(17), 3152-3161. https://doi.org/10.1016/j.yexcr.2008.07.027

in bone, angiogenesis most be initiated appropriately, but limited once remodelling or repair is complete. Our recent findings have Supported a role for prostaglandins (PG), known modulators of osteoblast (OB) and endothelial cell (EC) behaviour, in... Read More about Heterotypic contact reveals a COX-2-mediated suppression of osteoblast differentiation by endothelial cells: A negative modulatory role for prostanoids in VEGF-mediated cell: cell communication?.