Radiation hybrid mapping of all 10 characterized bovine Toll-like receptors
Journal Article
McGuire, K., Jones, M., Werling, D., Williams, J. L., Glass, E. J., & Jann, O. C. Radiation hybrid mapping of all 10 characterized bovine Toll-like receptors. Animal Genetics, 37(1), 47-50. https://doi.org/10.1111/j.1365-2052.2005.01364.x
All Outputs (139)
Expression of TOLL-like receptors (TLR) by bovine antigen-presenting cells - Potential role in pathogen discrimination?
Journal Article
Werling, D., Piercy, J., & Coffey, T. J. Expression of TOLL-like receptors (TLR) by bovine antigen-presenting cells - Potential role in pathogen discrimination?. Veterinary Immunology and Immunopathology, 112(1-2), 2-11. https://doi.org/10.1016/j.vetimm.2006.03.007
Identification and gene expression of the bovine C-type lectin Dectin-1
Journal Article
Willcocks, S., Yamakawa, Y., Stalker, A., Coffey, T. J., Goldammer, T., & Werling, D. Identification and gene expression of the bovine C-type lectin Dectin-1. Veterinary Immunology and Immunopathology, 113(1-2), 234-242. https://doi.org/10.1016/j.vetimm.2006.04.007
C-Myc activation by Theileria parasites promotes survival of infected B-lymphocytes
Journal Article
Dessauge, G., Hilaly, S., Baumgartner, M., Blumen, B., Werling, D., & Langsley, G. C-Myc activation by Theileria parasites promotes survival of infected B-lymphocytes. Oncogene, 24(6), 1075-1083. https://doi.org/10.1038/sj.onc.1208314
Differential production of cytokines, reactive oxygen and nitrogen by bovine macrophages and dendritic cells stimulated with Toll-like receptor agonists
Journal Article
Werling, D., Hope, J., Howard, C. J., & Jungi, T. W. Differential production of cytokines, reactive oxygen and nitrogen by bovine macrophages and dendritic cells stimulated with Toll-like receptor agonists. Immunology, 111(1), 41-52. https://doi.org/10.1046/j.1365-2567.2003.01781.x
A tumour necrosis factor alpha autocrine loop contributes to proliferation and nuclear factor-kappa B activation of Theileria parva-transformed B cells
Journal Article
Guergnon, J., Chaussepied, M., Sopp, P., Lizundia, R., Moreau, M. F., Blumen, B., Werling, D., Howard, C. J., & Langsley, G. A tumour necrosis factor alpha autocrine loop contributes to proliferation and nuclear factor-kappa B activation of Theileria parva-transformed B cells. Cellular Microbiology, 5(10), 709-716. https://doi.org/10.1046/j.1462-5822.2003.00314.x
Role of sugars in surface microbe-host interactions and immune reaction modulation
Journal Article
Lloyd, D. H., Viac, J., Werling, D., Reme, C. A., & Gatto, H. Role of sugars in surface microbe-host interactions and immune reaction modulation. Veterinary Dermatology, 18(4), 197-204. https://doi.org/10.1111/j.1365-3164.2007.00594.x
Identification and functional characterization of a bovine orthologue to DC-SIGN
Journal Article
Yamakawa, Y., Pennelegion, C., Willcocks, S., Stalker, A., MacHugh, N., Burt, D., Coffey, T. J., & Werling, D. Identification and functional characterization of a bovine orthologue to DC-SIGN. Journal of Leukocyte Biology, 83(6), 1396-1403. https://doi.org/10.1189/jlb.0807523Dendritic cell-specific ICAM-3-grabbing nonintegrin (DC-SIGN) C-type lectin is almost exclusively expressed at the cell surface of DC. In addition to its normal function facilitating contact of DC with T cells, DC-SIGN has been shown to bind a variet... Read More about Identification and functional characterization of a bovine orthologue to DC-SIGN.
CROSS-REACTIVITY OF MABS TO HUMAN CD ANTIGENS WITH CELLS FROM CATTLE (VOL 119, PG 106, 2007)
Journal Article
Sopp, P., Werling, D., & Baldwin, C. CROSS-REACTIVITY OF MABS TO HUMAN CD ANTIGENS WITH CELLS FROM CATTLE (VOL 119, PG 106, 2007). Veterinary Immunology and Immunopathology, 122(1-2), 188-189
Molecular evolution of bovine Toll-like receptor 2 suggests substitutions of functional relevance
Journal Article
Jann, O. C., Werling, D., Chang, J. S., Haig, D., & Glass, E. J. Molecular evolution of bovine Toll-like receptor 2 suggests substitutions of functional relevance. BMC Evolutionary Biology, 8(288), https://doi.org/10.1186/1471-2148-8-288Background: There is accumulating evidence that polymorphism in Toll-like receptor (TLR) genes might be associated with disease resistance or susceptibility traits in livestock. Polymorphic sites affecting TLR function should exhibit signatures of po... Read More about Molecular evolution of bovine Toll-like receptor 2 suggests substitutions of functional relevance.
Transboundary disease management: The theory and the practice - The science and the politics
Journal Article
Kitching, P., Thomson, G., Albrecht, S., Sabara, M., & Werling, D. Transboundary disease management: The theory and the practice - The science and the politics. Transboundary and Emerging Diseases, 55(1), 1-2
Host species-specific usage of the TLR4-LPS receptor complex
Journal Article
Lizundia, R., Sauter, K. S., Taylor, G., & Werling, D. Host species-specific usage of the TLR4-LPS receptor complex. Innate Immunity, 14(4), 223-231. https://doi.org/10.1177/1753425908095957Recognition of LIPS depends on the interaction of at least three molecules forming the LPS-receptor complex. The Most important ones, CD14. MD2 and Toll-like receptor (TLR) 4 share a high degree of homology between species. In the present study, we i... Read More about Host species-specific usage of the TLR4-LPS receptor complex.
Poly I:C stimulation in-vitro as a marker for an antiviral response in different cell types generated from Buffalo (Bubalus bubalis)
Journal Article
Vats, A., Gautam, D., Maharana, J., Chera, J. S., Kumar, S., Werling, D., & De, S. (in press). Poly I:C stimulation in-vitro as a marker for an antiviral response in different cell types generated from Buffalo (Bubalus bubalis). Molecular Immunology, 121, 136-143. https://doi.org/10.1016/j.molimm.2020.03.004The innate immune system is activated upon virus invasion of a host cell by recognizing viral component, such as dsRNA through specific receptors, resulting in the production of type- I IFNs, which confer an antiviral state within the invaded as well... Read More about Poly I:C stimulation in-vitro as a marker for an antiviral response in different cell types generated from Buffalo (Bubalus bubalis).
Poly I:C stimulation in-vitro as a marker for an antiviral response in different cell types generated from Buffalo (Bubalus bubalis)
Journal Article
Vats, A., Gautam, D., Maharana, J., Singh Chera, J., Kumar, S., Rout, P. K., Werling, D., & De, S. Poly I:C stimulation in-vitro as a marker for an antiviral response in different cell types generated from Buffalo (Bubalus bubalis). Molecular Immunology, 121, 136-143The innate immune system is activated upon virus invasion of a host cell by recognizing viral component, such as dsRNA through specific receptors, resulting in the production of type- I IFNs, which confer an antiviral state within the invaded as well... Read More about Poly I:C stimulation in-vitro as a marker for an antiviral response in different cell types generated from Buffalo (Bubalus bubalis).
Prediction of metabolic clusters in early-lactation dairy cows using models based on milk biomarkers
Journal Article
De Koster, J., Salavati, M., Grelet, C., Crowe, M. A., Matthews, E., O'Flaherty, R., Opsomer, G., Foldager, L., Hostens, M., McLoughlin, N., Fahey, A., Santoro, A., Byrne, C., Rudd, P., Hallinan, S., Wathes, D. C., Cheng, Z. R., Fouladi-Nashta, A. A., Pollott, G., Werling, D., …Vrea, S. P. Prediction of metabolic clusters in early-lactation dairy cows using models based on milk biomarkers. Journal of Dairy Science, 102(3), 2631-2644. https://doi.org/10.3168/jds.2018-15533
Cardiosphere-derived cells suppress allogeneic lymphocytes by production of PGE2 acting via the EP4 receptor
Journal Article
Dutton, L. C., Dudhia, J., Catchpole, B., Hodhkiss-Geere, H., Werling, D., & Connolly, D. J. (in press). Cardiosphere-derived cells suppress allogeneic lymphocytes by production of PGE2 acting via the EP4 receptor. https://doi.org/10.1038/s41598-018-31569-1derived cells (CDCs) are a cardiac progenitor cell population, which have been shown to possess cardiac regenerative properties and can improve heart function in a variety of cardiac diseases. Studies in large animal models have predominantly focusse... Read More about Cardiosphere-derived cells suppress allogeneic lymphocytes by production of PGE2 acting via the EP4 receptor.
The immune system is part of a whole-organism regulatory network
Journal Article
Werling, D. The immune system is part of a whole-organism regulatory network. Research in Veterinary Science, https://doi.org/10.1016/j.rvsc.2017.09.018
Bovine P-selectin mediates leukocyte adhesion and is highly polymorphic in dairy breeds
Journal Article
Chen, X., Cheng, Z. R., Werling, D., Pollott, G. E., Salavati, M., Johnson, K. F., Khan, F. A., Wathes, D. C., & Zhang, S. J. (in press). Bovine P-selectin mediates leukocyte adhesion and is highly polymorphic in dairy breeds. Research in Veterinary Science, 108, 85-92. https://doi.org/10.1016/j.rvsc.2016.08.004
Differential Macrophage Function in Brown Swiss and Holstein Friesian Cattle
Journal Article
Gibson, A. J., Woodman, S., Pennelegion, C., Patterson, R., Stuart, E., Hosker, N., Siviter, P., Douglas, C., Whitehouse, J., Wilkinson, W., Pegg, S. A., Villarreal-Ramos, B., & Werling, D. (in press). Differential Macrophage Function in Brown Swiss and Holstein Friesian Cattle. Veterinary Immunology and Immunopathology, 181, 15-23. https://doi.org/10.1016/j.vetimm.2016.02.018
Live and inactivated Salmonella enterica serovar Typhimurium stimulate similar but distinct transcriptome profiles in bovine macrophages and dendritic cells
Journal Article
Jensen, K., Gallagher, I. J., Kaliszewska, A., Zhang, C., Abejide, O., Gallagher, M. P., Werling, D., & Glass, E. J. (in press). Live and inactivated Salmonella enterica serovar Typhimurium stimulate similar but distinct transcriptome profiles in bovine macrophages and dendritic cells. Veterinary Research, 47(46), https://doi.org/10.1186/s13567-016-0328-y